Search Results - "Guardia, Gabriela D A"

The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation by Kosti, Adam, de Araujo, Patricia Rosa, Li, Wei-Qing, Guardia, Gabriela D A, Chiou, Jennifer, Yi, Caihong, Ray, Debashish, Meliso, Fabiana, Li, Yi-Ming, Delambre, Talia, Qiao, Mei, Burns, Suzanne S, Lorbeer, Franziska K, Georgi, Fanny, Flosbach, Markus, Klinnert, Sarah, Jenseit, Anne, Lei, Xiufen, Sandoval, Carolina Romero, Ha, Kevin, Zheng, Hong, Pandey, Renu, Gruslova, Aleksandra, Gupta, Yogesh K, Brenner, Andrew, Kokovay, Erzsebet, Hughes, Timothy R, Morris, Quaid D, Galante, Pedro A F, Tiziani, Stefano, Penalva, Luiz O F

“…RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in RBP expression and function are often observed in cancer and…”
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Impact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies by Giolito, Maria Virginia, Bodoirat, Serguei, La Rosa, Theo, Reslinger, Mathieu, Guardia, Gabriela D. A., Mourtada, Jana, Claret, Leo, Joung, Alain, Galante, Pedro A. F., Penalva, Luiz O. F., Plateroti, Michelina

“…Colorectal cancers (CRCs) are highly heterogeneous and show a hierarchical organization, with cancer stem cells (CSCs) responsible for tumor development,…”
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Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression by Costa, Pedro A C, Silva, Walison N, Prazeres, Pedro H D M, Picoli, Caroline C, Guardia, Gabriela D A, Costa, Alinne C, Oliveira, Mariana A, Guimarães, Pedro P G, Gonçalves, Ricardo, Pinto, Mauro C X, Amorim, Jaime H, Azevedo, Vasco A C, Resende, Rodrigo R, Russo, Remo C, Cunha, Thiago M, Galante, Pedro A F, Mintz, Akiva, Birbrair, Alexander

“…Sensory neurons have recently emerged as components of the tumor microenvironment. Nevertheless, whether sensory neuronal activity is important for tumor…”
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Retro-miRs: novel and functional miRNAs originating from mRNA retrotransposition by Mercuri, Rafael L. V, Conceição, Helena B, Guardia, Gabriela D. A, Goldstein, Gabriel, Vibranovski, Maria D, Hinske, Ludwig C, Galante, Pedro A. F

“…Abstract Background Reverse-transcribed gene copies (retrocopies) have emerged as major sources of evolutionary novelty. MicroRNAs (miRNAs) are small and…”
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A Methodology for the Development of RESTful Semantic Web Services for Gene Expression Analysis by Guardia, Gabriela D A, Pires, Luís Ferreira, Vêncio, Ricardo Z N, Malmegrim, Kelen C R, de Farias, Cléver R G

“…Gene expression studies are generally performed through multi-step analysis processes, which require the integrated use of a number of analysis tools. In order…”
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Identification of a novel alternative splicing isoform of the Hippo kinase STK3/MST2 with impaired kinase and cell growth suppressing activities by Rodrigues, Ana Maria, Paula Zen Petisco Fiore, Ana, Guardia, Gabriela D. A., Tomasin, Rebeka, Azevedo Reis Teixeira, André, Giordano, Ricardo Jose, Schechtman, Deborah, Pagano, Michele, Galante, Pedro A. F., Bruni-Cardoso, Alexandre

“…Mammalian Ste-20-like Kinases 1 and 2 (MST1/2) are core serine-threonine kinases of the Hippo pathway regulating several cellular processes, including cell…”
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Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Perspective for Emerging More Transmissible and Vaccine-Resistant Strains by de Souza, Anacleto Silva, de Freitas Amorim, Vitor Martins, Guardia, Gabriela D A, Dos Santos, Filipe F, Ulrich, Henning, Galante, Pedro A F, de Souza, Robson Francisco, Guzzo, Cristiane Rodrigues

“…Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) are constantly threatening global public health. With no end date,…”
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Acute Myeloid Leukemia Expresses a Specific Group of Olfactory Receptors by Guardia, Gabriela D A, Naressi, Rafaella G, Buzzato, Vanessa C, da Costa, Juliana B, Zalcberg, Ilana, Ramires, Jordana, Malnic, Bettina, Gutiyama, Luciana M, Galante, Pedro A F

“…Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults, with a 5-year overall survival rate of approximately 30%. Despite recent…”
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Interplay between Tumor Mutational Burden and Mutational Profile and Its Effect on Overall Survival: A Pilot Study of Metastatic Patients Treated with Immune Checkpoint Inhibitors by Xavier, Camila B, Lopes, Carlos Diego H, Awni, Beatriz M, Campos, Eduardo F, Alves, João Pedro B, Camargo, Anamaria A, Guardia, Gabriela D A, Galante, Pedro A F, Jardim, Denis L

“…Purpose: Solid tumors harboring tumor mutational burden (TMB) ≥10 mutations per megabase (mut/Mb) received agnostic approval for pembrolizumab. This work aims…”
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The paralogues MAGOH and MAGOHB are oncogenic factors in high-grade gliomas and safeguard the splicing of cell division and cell cycle genes by Barreiro, Rodrigo A. S., Guardia, Gabriela D. A., Meliso, Fabiana M., Lei, Xiufen, Li, Wei-Qing, Savio, Andre, Fellermeyer, Martin, Conceição, Helena B., Mercuri, Rafael L. V., Landry, Tesha, Qiao, Mei, Blazquez, Lorea, Ule, Jernej, Penalva, Luiz O.F., Galante, Pedro A. F.

“…The exon junction complex (EJC) plays key roles throughout the lifespan of RNA and is particularly relevant in the nervous system. We investigated the roles of…”
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Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions by Giolito, Maria Virginia, La Rosa, Théo, Farhat, Diana, Bodoirat, Serguei, Guardia, Gabriela D. A., Domon‐Dell, Claire, Galante, Pedro A. F., Freund, Jean‐Noel, Plateroti, Michelina

“…The THRA gene, encoding the thyroid hormone nuclear receptor TRα1, is expressed in an increasing gradient at the bottom of intestinal crypts, overlapping with…”
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Tissue-resident glial cells associate with tumoral vasculature and promote cancer progression by Rocha, Beatriz G. S., Picoli, Caroline C., Gonçalves, Bryan O. P., Silva, Walison N., Costa, Alinne C., Moraes, Michele M., Costa, Pedro A. C., Santos, Gabryella S. P., Almeida, Milla R., Silva, Luciana M., Singh, Youvika, Falchetti, Marcelo, Guardia, Gabriela D. A., Guimarães, Pedro P. G., Russo, Remo C., Resende, Rodrigo R., Pinto, Mauro C. X., Amorim, Jaime H., Azevedo, Vasco A. C., Kanashiro, Alexandre, Nakaya, Helder I., Rocha, Edroaldo L., Galante, Pedro A. F., Mintz, Akiva, Frenette, Paul S., Birbrair, Alexander

“…Cancer cells are embedded within the tissue and interact dynamically with its components during cancer progression. Understanding the contribution of cellular…”
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Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development by Velasco, Mitzli X, Kosti, Adam, Guardia, Gabriela D A, Santos, Marcia C, Tegge, Allison, Qiao, Mei, Correa, Bruna R S, Hernández, Greco, Kokovay, Erzsebet, Galante, Pedro A F, Penalva, Luiz O F

“…RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We…”
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Proneural and mesenchymal glioma stem cells display major differences in splicing and lncRNA profiles by Guardia, Gabriela D. A., Correa, Bruna R., Araujo, Patricia Rosa, Qiao, Mei, Burns, Suzanne, Penalva, Luiz O. F., Galante, Pedro A. F.

“…Therapy resistance and recurrence in high-grade gliomas are driven by their populations of glioma stem cells (GSCs). Thus, detailed molecular characterization…”
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The RNA-Binding Protein Musashi1 Regulates a Network of Cell Cycle Genes in Group 4 Medulloblastoma by Baroni, Mirella, Guardia, Gabriela D A, Lei, Xiufen, Kosti, Adam, Qiao, Mei, Landry, Tesha, Mau, Karl, Galante, Pedro A F, Penalva, Luiz O F

“…Medulloblastoma is the most common malignant brain tumor in children. Treatment with surgery, irradiation, and chemotherapy has improved survival in recent…”
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RCPedia: a global resource for studying and exploring retrocopies in diverse species by Conceição, Helena B, Mercuri, Rafael L V, de Castro, Matheus P M, Ohara, Daniel T, Guardia, Gabriela D A, Galante, Pedro A F

“…Gene retrocopies arise from the reverse transcription and genomic insertion of processed mRNA transcripts. These elements have significantly contributed to…”
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Population Dynamics is a Cancer Driver by Dos Santos Oliveira, Mariana, de C Griebeler, Marcelo, Henz, Bernardo, Ferreira Dos Santos, Filipe, Guardia, Gabriela D A, Conceição, Helena B, Galante, Pedro A F, Minussi, Darlan C, Oliveira, Manuel M, Lenz, Guido

“…Most tissues are continuously renovated through the division of stem cells and the death of old or damaged cells, which is known as cell turnover rate (CTOR)…”
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A UML profile for the OBO relation ontology by Guardia, Gabriela D A, Vêncio, Ricardo Z N, de Farias, Cléver R G

“…Ontologies have increasingly been used in the biomedical domain, which has prompted the emergence of different initiatives to facilitate their development and…”
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Semantic integration of gene expression analysis tools and data sources using software connectors by Miyazaki, Flávia A, Guardia, Gabriela D A, Vêncio, Ricardo Z N, de Farias, Cléver R G

“…The study and analysis of gene expression measurements is the primary focus of functional genomics. Once expression data is available, biologists are faced…”
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ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics by Kosti, Adam, Chiou, Jennifer, Guardia, Gabriela D A, Lei, Xiufen, Balinda, Henriette, Landry, Tesha, Lu, Xiyuan, Qiao, Mei, Gilbert, Andrea, Brenner, Andrew, Galante, Pedro A F, Tiziani, Stefano, Penalva, Luiz O F

“…Abstract Background The loss of neurogenic tumor suppressor microRNAs miR-124, miR-128, and miR-137 is associated with glioblastoma’s undifferentiated state…”
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