Search Results - "Guan, Youxin"

Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma by Moore, Amanda R, Ceraudo, Emilie, Sher, Jessica J, Guan, Youxin, Shoushtari, Alexander N, Chang, Matthew T, Zhang, Jenny Q, Walczak, Edward G, Kazmi, Manija A, Taylor, Barry S, Huber, Thomas, Chi, Ping, Sakmar, Thomas P, Chen, Yu

“…Yu Chen and colleagues describe a new constitutively activating mutation in the G-protein-coupled receptor CYSLTR2 in patients with uveal melanoma lacking…”
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iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function by Ni, Peiyan, Noh, Haneul, Park, Gun-Hoo, Shao, Zhicheng, Guan, Youxin, Park, James M., Yu, Sophy, Park, Joy S., Coyle, Joseph T., Weinberger, Daniel R., Straub, Richard E., Cohen, Bruce M., McPhie, Donna L., Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi

“…Schizophrenia (SCZ) is a neurodevelopmental disorder. Thus, studying pathogenetic mechanisms underlying SCZ requires studying the development of brain cells…”
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Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia by Park, Gun-Hoo, Noh, Haneul, Shao, Zhicheng, Ni, Peiyan, Qin, Yiren, Liu, Dongxin, Beaudreault, Cameron P., Park, Joy S., Abani, Chiderah P., Park, James M., Le, Derek T., Gonzalez, Sasha Z., Guan, Youxin, Cohen, Bruce M., McPhie, Donna L., Coyle, Joseph T., Lanz, Thomas A., Xi, Hualin S., Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi

“…The mechanisms by which prenatal immune activation increase the risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical…”
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T1-weighted Dynamic Contrast-enhanced MRI to Differentiate Nonneoplastic and Malignant Vertebral Body Lesions in the Spine by Guan, Youxin, Peck, Kyung K, Lyo, John, Tisnado, Jamie, Lis, Eric, Arevalo-Perez, Julio, Yamada, Yoshiya, Hameed, Meera R, Karimi, Sasan, Holodny, Andrei

“…Background Dynamic contrast agent-enhanced (DCE) perfusion MRI may help differentiate between nonneoplastic and malignant lesions in the spine. Purpose To…”
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ETV1-Positive Cells Give Rise to BRAFV600E -Mutant Gastrointestinal Stromal Tumors by Ran, Leili, Murphy, Devan, Sher, Jessica, Cao, Zhen, Wang, Shangqian, Walczak, Edward, Guan, Youxin, Xie, Yuanyuan, Shukla, Shipra, Zhan, Yu, Antonescu, Cristina R., Chen, Yu, Chi, Ping

“…Abstract Gastrointestinal stromal tumor (GIST) is the most common subtype of sarcoma. Despite clinical advances in the treatment of KIT/PDGFRA–mutant GIST,…”
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FOXF1 Defines the Core-Regulatory Circuitry in Gastrointestinal Stromal Tumor by Ran, Leili, Chen, Yuedan, Sher, Jessica, Wong, Elissa W P, Murphy, Devan, Zhang, Jenny Q, Li, Dan, Deniz, Kemal, Sirota, Inna, Cao, Zhen, Wang, Shangqian, Guan, Youxin, Shukla, Shipra, Li, Katie Yang, Chramiec, Alan, Xie, Yuanyuan, Zheng, Deyou, Koche, Richard P, Antonescu, Cristina R, Chen, Yu, Chi, Ping

“…The cellular context that integrates upstream signaling and downstream nuclear response dictates the oncogenic behavior and shapes treatment responses in…”
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A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon by Gao, Dong, Zhan, Yu, Di, Wei, Moore, Amanda R, Sher, Jessica J, Guan, Youxin, Wang, Shangqian, Zhang, Zeda, Murphy, Devan A, Sawyers, Charles L, Chi, Ping, Chen, Yu

“…Fusion between TMPRSS2 and ERG, placing ERG under the control of the TMPRSS2 promoter, is the most frequent genetic alteration in prostate cancer, present in…”
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GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma by Moore, Amanda R., Ran, Leili, Guan, Youxin, Sher, Jessica J., Hitchman, Tyler D., Zhang, Jenny Q., Hwang, Catalina, Walzak, Edward G., Shoushtari, Alexander N., Monette, Sébastien, Murali, Rajmohan, Wiesner, Thomas, Griewank, Klaus G., Chi, Ping, Chen, Yu

“…Uveal melanoma (UM) is characterized by mutually exclusive activating mutations in GNAQ, GNA11, CYSLTR2, and PLCB4, four genes in a linear pathway to…”
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Large-Scale Generation and Characterization of Homogeneous Populations of Migratory Cortical Interneurons from Human Pluripotent Stem Cells by Ni, Peiyan, Noh, Haneul, Shao, Zhicheng, Zhu, Qian, Guan, Youxin, Park, Joshua J., Arif, Fatima, Park, James M., Abani, Chiderah, Beaudreault, Cameron, Park, Joy S., Berry, Elizabeth, Moghadam, Alexander, Stanton, Patric, Hutchinson, John N., Andrews, Bill, Faux, Clare, Parnevelas, John, Eisenberg, Leonard M., Park, Kyungjoon, Bolshakov, Vadim Y., Chung, Sangmi

“…During development, cortical interneurons (cINs) are generated from the ventral telencephalon, robustly migrate to the dorsal telencephalon, make local…”
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Abstract A07: Activating mutations in uveal melanoma convey sensitivity to g-alpha q inhibition by Hitchman, Tyler D., Ceraudo, Emilie, Moore, Amanda R., Shoushtari, Alexander N., Francis, Jasmine H., Guan, Youxin, Chen, Juliet, Chang, Matthew T., Taylor, Barry S., Sakmar, Thomas P., Huber, Thomas, Chi, Ping, Chen, Yu

“…Abstract Uveal melanoma (UVM) is the most common intraocular malignancy, which represents about 5% of all melanoma cases per year in the United States. Half of…”
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COP1/DET1/ETS axis regulates ERK transcriptome and sensitivity to MAPK inhibitors by Xie, Yuanyuan, Cao, Zhen, Wong, Elissa Wp, Guan, Youxin, Ma, Wenfu, Zhang, Jenny Q, Walczak, Edward G, Murphy, Devan, Ran, Leili, Sirota, Inna, Wang, Shangqian, Shukla, Shipra, Gao, Dong, Knott, Simon Rv, Chang, Kenneth, Leu, Justin, Wongvipat, John, Antonescu, Cristina R, Hannon, Gregory, Chi, Ping, Chen, Yu

“…Aberrant activation of MAPK signaling leads to the activation of oncogenic transcriptomes. How MAPK signaling is coupled with the transcriptional response in…”
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Activated microglia cause metabolic disruptions in developmental cortical interneuron that persist in schizophrenia-patient-derived interneurons by Park, Gun-Hoo, Noh, Haneul, Shao, Zhicheng, Ni, Peiyan, Qin, Yiren, Liu, Dongxin, Beaudreault, Cameron P., Park, Joy S., Abani, Chiderah P., Park, James M., Le, Derek T., Gonzalez, Sasha Z., Guan, Youxin, Cohen, Bruce M., McPhie, Donna L., Coyle, Joseph T., Lanz, Thomas A., Xi, Hualin S, Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi

“…The mechanisms by which prenatal immune activation increase risk for neuropsychiatric disorders are unclear. Here, we generated developmental cortical…”
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Correction: iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function by Ni, Peiyan, Noh, Haneul, Park, Gun-Hoo, Shao, Zhicheng, Guan, Youxin, Park, James M., Yu, Sophy, Park, Joy S., Coyle, Joseph T., Weinberger, Daniel R., Straub, Richard E., Cohen, Bruce M., McPhie, Donna L., Yin, Changhong, Huang, Weihua, Kim, Hae-Young, Chung, Sangmi

“…A correction to this paper has been published and can be accessed via a link at the top of the paper…”
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Abstract A15: Modeling sporadic gastrointestinal stromal tumor with BRAFV600E mutation by Ran, Leili, Murphy, Devan, Sher, Jessica, Cao, Zhen, Wang, Shangqian, Walczak, Edward, Guan, Youxin, Xie, Yuanyuan, Shukla, Shipra, Zhan, Yu, Antonescu, Cristina R., Chen, Yu, Chi, Ping

“…Abstract Gastrointestinal stromal tumor (GIST) is the most common subtype of sarcoma, characterized by activating mutations in KIT, PDGFRA, BRAF, N/H/KRAS, and…”
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GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma by Moore, Amanda R., Ran, Leili, Guan, Youxin, Sher, Jessica J., Hitchman, Tyler D., Zhang, Jenny Q., Hwang, Catalina, Walczak, Edward G., Shoushtari, Alexander N., Monette, Sébastien, Murali, Rajmohan, Wiesner, Thomas, Griewank, Klaus G., Chi, Ping, Chen, Yu

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Abstract B13: COP1-ETS axis regulates ERK transcriptional output and modulates sensitivity to MAPK inhibitors by Xie, Yuanyuan, Cao, Zhen, Wong, Wai Pung, Guan, Youxin, Zhang, Jenny, Walczak, Edward, Murphy, Devan, Ran, Leili, Sirota, Inna, Wang, Shangqian, Shukla, Shipra, Gao, Dong, Wongvipat, John, Knott, Simon, Chang, Kenneth, Antonescu, Cristina, Hannon, Gregory, Chi, Ping, Chen, Yu

“…Abstract Aberrant activation of the mitogen activate kinase (MAPK) pathway is highly prevalent in cancer and therapies targeting the pathway are approved or…”
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Combined Inhibition of Gα q and MEK Enhances Therapeutic Efficacy in Uveal Melanoma by Hitchman, Tyler D, Bayshtok, Gabriella, Ceraudo, Emilie, Moore, Amanda R, Lee, Cindy, Jia, Ruobing, Wang, Naitao, Pachai, Mohini R, Shoushtari, Alexander N, Francis, Jasmine H, Guan, Youxin, Chen, Juliet, Chang, Matthew T, Taylor, Barry S, Sakmar, Thomas P, Huber, Thomas, Chi, Ping, Chen, Yu

“…All uveal melanoma and a fraction of other melanoma subtypes are driven by activation of the G-protein alpha-q (Gα ) pathway. Targeting these melanomas has…”
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A Tmprss2-CreER.sup.T2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon by Gao, Dong, Zhan, Yu, Di, Wei, Moore, Amanda R, Sher, Jessica J, Guan, Youxin, Wang, Shangqian, Zhang, Zeda, Murphy, Devan A, Sawyers, Charles L, Chi, Ping, Chen, Yu

“…Fusion between TMPRSS2 and ERG, placing ERG under the control of the TMPRSS2 promoter, is the most frequent genetic alteration in prostate cancer, present in…”
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MP55-20 ESTABLISHMENT OF LUCAP CELL LINES BY “ORGANOID” IN VITRO CULTURE TECHNOLOGY by Dowling, Catherine, Gao, Dong, Kaffenberger, Samuel, Guan, Youxin, Zhang, Qi Fan, Murphy, Devan, Nguyen, Holly, Corey, Eva, Chen, Yu

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Zebrafish Enhancer TRAP transgenic line database ZETRAP 2.0 by Kondrychyn, Igor, Teh, Cathleen, Garcia-Lecea, Marta, Guan, Youxin, Kang, Ann, Korzh, Vladimir

“…Our first Zebrafish Enhancer TRAP lines database (ZETRAP) generated a few years ago was a web-based system informing the scientific community about the…”
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