Search Results - "Guan, Kaifang"

Synergistic effects of MFG-E8 and whey protein on mitigating d-galactose-induced sarcopenia through PI3K/AKT/PGC-1α and MAPK/ERK signaling pathways by Li, He, Guan, Kaifang, Wang, Rongchun, Zhu, Aihua, Ma, Ying

“…Milk fat globule epidermal growth factor 8 (MFG-E8) and whey protein have emerged as promising bionutrient supplements for enhancing skeletal muscle mass and…”
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Whey protein peptides PEW and LLW synergistically ameliorate hyperuricemia and modulate gut microbiota in potassium oxonate and hypoxanthine-induced hyperuricemic rats by Qi, Xiaofen, Guan, Kaifang, Liu, Chunhong, Chen, Haoran, Ma, Ying, Wang, Rongchun

“…PEW and LLW are peptides derived from whey protein digestive products; both peptides exhibit xanthine oxidase inhibitory activity in vitro. However, it remains…”
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Identification and antioxidative mechanism of novel mitochondria-targeted MFG-E8 polypeptides in virtual screening and in vitro study by Guan, Kaifang, Li, He, Liu, DanDan, Liu, Min, He, Canxia

“…Milk fat globule-EGF factor VIII (MFG-E8) has been identified as an important source of bioactive peptides, which may exert a pivotal role in regulating…”
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Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells by Chen, Haoran, Qi, Xiaofen, Guan, Kaifang, Wang, Rongchun, Li, Qiming, Ma, Ying

“…The objective of this study was to investigate the mechanism by which the α-lactalbumin peptides Gly-Ile-Asn-Tyr (GINY) and Asp-Gln-Trp (DQW) ameliorate free…”
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Peptides released from bovine α-lactalbumin by simulated digestion alleviated free fatty acids-induced lipid accumulation in HepG2 cells by Chen, Haoran, Qi, Xiaofen, Guan, Kaifang, Gu, Yuxiang, Wang, Rongchun, Li, Qiming, Ma, Ying

“…•Peptides from α-LA decreased lipid accumulation in HepG2 cells.•The peptides of P2 (GINY) and P8 (DQW) acted as PPARα ligands.•P2 and P8 up-regulated genes…”
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α-Lactalbumin ameliorates hepatic lipid metabolism in high-fat-diet induced obese C57BL/6J mice by Chen, Haoran, Guan, Kaifang, Qi, Xiaofen, Wang, Rongchun, Ma, Ying

“…α-Lactalbumin improves high-fat-diet induced obesity and hepatic lipid metabolism by activating fatty acid β-oxidation and inhibiting lipogenesis in the liver…”
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Paraprobiotics 5-PA and 6-PA restore intestinal homeostasis by inhibiting NF-κB/NLRP3 signaling pathway and alleviating dysbiosis in mice with chronic ulcerative colitis by Liu, Chunhong, Qi, Xiaofen, Guan, Kaifang, Chen, Haoran, Li, Qiming, Mao, Kaidong, Shen, Guiqi, Ma, Ying

“…[Display omitted] •Paraprobiotics 5-PA and 6-PA derived from the anti-inflammatory probiotics HF05 and HF06, respectively, alleviated weight loss and…”
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Anti‐hyperuricemic and nephroprotective effects of whey protein hydrolysate in potassium oxonate induced hyperuricemic rats by Qi, Xiaofen, Chen, Haoran, Guan, Kaifang, Wang, Rongchun, Ma, Ying

“…BACKGROUND Hyperuricemia (HUA) is a serious public health concern globally that needs to be solved. It is closely related to gout and other metabolic diseases…”
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Identification, inhibitory mechanism and transepithelial transport of xanthine oxidase inhibitory peptides from whey protein after simulated gastrointestinal digestion and intestinal absorption by Qi, Xiaofen, Chen, Haoran, Guan, Kaifang, Sun, Yue, Wang, Rongchun, Ma, Ying

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Whey Protein Peptide Pro-Glu-Trp Ameliorates Hyperuricemia by Enhancing Intestinal Uric Acid Excretion, Modulating the Gut Microbiota, and Protecting the Intestinal Barrier in Rats by Qi, Xiaofen, Ma, Yanfeng, Guan, Kaifang, Zhao, Le, Ma, Ying, Wang, Rongchun

“…Hyperuricemia (HUA) is a metabolic disorder characterized by an increase in the concentrations of uric acid (UA) in the bloodstream, intricately linked to the…”
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Novel antioxidant peptides from MFGM protein Hydrolysates: Separation, identification and effects on Dexamethasone-induced mitochondrial dysfunction by Li, He, Guan, Kaifang, Liu, Min, Liu, Dandan, Wang, Wenqiong, Zhu, Aihua

“…[Display omitted] •The MFGM antioxidant peptides were prepared, separated and purified by in vitro digestion and DEAE-52.•The novel cellular antioxidant…”
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Evaluation of FAAs and FFAs in yogurts fermented with different starter cultures during storage by Gu, Yuxiang, Li, Xing, Chen, Haoran, Guan, Kaifang, Qi, Xiaofen, Yang, Lin, Ma, Ying

“…•FAA and FFA profiles among yogurts varied with starter strains.•Various LAB combinations led to the different changes in FAAs/FFAs during storage.•SCFAs…”
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Intestinal barrier, immunity and gut microbiota-based protective effects of Lactococcus lactis HF08 and its postbiotic derivative on aging and aging colitis mice by Liu, Xiaolin, Ma, Ying, Guan, Kaifang, Liu, Rongmei, Mao, Kaidong, Xu, Xiaogang, Li, Qiming, Wang, Rongchun

“…[Display omitted] •Both of HF08 and P-HF08 enhanced intestinal function in D-gal induced aging mice.•Both HF08 and P-HF08 alleviated colitis in aging mice…”
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Novel xanthine oxidase inhibitory peptides derived from whey protein: identification, in vitro inhibition mechanism and in vivo activity validation by Qi, Xiaofen, Chen, Haoran, Guan, Kaifang, Sun, Yue, Wang, Rongchun, Li, Qiming, Ma, Ying

“…[Display omitted] •The XO inhibitory peptide was screened by a combination of experimental isolation and molecular docking.•ALPM and LWM interacted with XO…”
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Identification of mitochondria-related hub genes in sarcopenia and functional regulation of MFG-E8 on ROS-mediated mitochondrial dysfunction and cell cycle arrest by Li, He, Guan, Kaifang, Liu, DanDan, Liu, Min

“…Sarcopenia has high prevalence in the elderly population, but the genes and pathways related to aging in elderly patients with sarcopenia are poorly…”
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MFG-E8 induced differences in proteomic profiles in mouse C2C12 cells and its effect on PI3K/Akt and ERK signal pathways by Li, He, Guan, Kaifang, Li, Xu, Ma, Ying, Zhou, Shaobo

“…Milk fat globule-EGF factor 8 (MFG-E8) is one of the major proteins in milk fat globule membrane. In this study, mouse-derived C2C12 myoblast cells were served…”
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Identification and anti-oxidative potential of milk fat globule membrane (MFGM)-derived bioactive peptides released through in vitro gastrointestinal digestion by Li, He, Guan, Kaifang, Liu, Min, Jiang, Wen, Yan, Fengjuan, Zhu, Aihua, Zhou, Shaobo

“…[Display omitted] •In vitro digestion of MFGM protein and its relative stability and structural properties.•MFGM-derived peptides exhibit strong binding…”
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The cytoprotection of milk-derived MFG-E8 on mitochondria-injured L6 cell via mediation of Akt/bcl-2/bax-caspase-3 signaling pathway by Guan, Kaifang, Qi, Xiaofen, Chen, Haoran, Ma, Ying

“…Mitochondria-dependent myoblast apoptosis induced by oxidative stress and decrease in successful protein synthesis play a crucial role in loss of muscle mass…”
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TMT-based quantitative proteomics analysis reveals the effect of bovine derived MFG-E8 against oxidative stress on rat L6 cells by Guan, Kaifang, Li, He, Chen, Haoran, Qi, Xiaofen, Wang, Rongchun, Ma, Ying

“…Sarcopenia is an aging-associated oxidative stress-induced mitochondrial dysfunction characterized by a decline in skeletal muscle mass, strength and function…”
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Characterization and evaluation of MFG-E8 protein-derived peptides: From isolation to functional assessment in skeletal muscle lipid metabolism by Li, He, Guan, Kaifang, Gao, Yangming, Dong, Huixun, Liu, Min, Zhu, Aihua

“…This research investigated preparation, identification and relative properties of milk fat globule epidermal growth factor Ⅷ (MFG-E8) protein-derived peptides…”
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