Search Results - "Guan, K."

AMP-activated protein kinase and cancer by Wang, W, Guan, K.-L

“…AMP-activated protein kinase (AMPK) is a cellular energy sensor that is conserved in eukaryotes. Elevated AMP/ATP ratio activates AMPK, which inhibits…”
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Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation by Yang, H, Liu, Y, Bai, F, Zhang, J-Y, Ma, S-H, Liu, J, Xu, Z-D, Zhu, H-G, Ling, Z-Q, Ye, D, Guan, K-L, Xiong, Y

“…The TET ( t en– e leven t ranslocation) family of α-ketoglutarate (α-KG)-dependent dioxygenases catalyzes the sequential oxidation of 5-methylcytosine (5mC) to…”
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Multiple genetic variations confer risks for obesity and type 2 diabetes mellitus in arab descendants from UAE by Osman, Wael, Tay, Guan K, Alsafar, Habiba

“…Background The United Arab Emirates (UAE) is one of the countries most threatened with obesity. Here we investigated associations between hundreds of…”
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Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? by Corradetti, M N, Guan, K-L

“…The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls many aspects of cellular physiology, including transcription, translation,…”
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STEM Pathways of Rural and Small-Town Students: Opportunities to Learn, Aspirations, Preparation, and College Enrollment by Saw, Guan K., Agger, Charlotte A.

“…Using the nationally representative High School Longitudinal Study of 2009 (HSLS:09), this study documents that rural and small-town students were…”
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Nanometallic Glasses: Size Reduction Brings Ductility, Surface State Drives Its Extent by Chen, D. Z, Jang, D, Guan, K. M, An, Q, Goddard, W. A, Greer, J. R

“…We report tensile experiments on Ni80P20 metallic glass samples fabricated via a templated electroplating process and via focused ion beam milling, which…”
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A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis by Azad, T., Janse van Rensburg, H. J., Lightbody, E. D., Neveu, B., Champagne, A., Ghaffari, A., Kay, V. R., Hao, Y., Shen, H., Yeung, B., Croy, B. A., Guan, K. L., Pouliot, F., Zhang, J., Nicol, C. J. B., Yang, X.

“…The Hippo pathway is a central regulator of tissue development and homeostasis, and has been reported to have a role during vascular development. Here we…”
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A 1000 Arab genome project to study the Emirati population by Al-Ali, Mariam, Osman, Wael, Tay, Guan K, AlSafar, Habiba S

“…Discoveries from the human genome, HapMap, and 1000 genome projects have collectively contributed toward the creation of a catalog of human genetic variations…”
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Immune response to SARS-CoV-2 variants: A focus on severity, susceptibility, and preexisting immunity by Alefishat, Eman, Jelinek, Herbert F., Mousa, Mira, Tay, Guan K., Alsafar, Habiba S.

“…The heterogeneous phenotypes among patients with coronavirus disease 2019 (COVID-19) has drawn worldwide attention, especially those with severe symptoms…”
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Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway by Liu, G, Yu, F-X, Kim, Y C, Meng, Z, Naipauer, J, Looney, D J, Liu, X, Gutkind, J S, Mesri, E A, Guan, K-L

“…Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic virus and the culprit behind the human disease Kaposi sarcoma (KS), an AIDS-defining malignancy…”
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Characterizing the diversity of MHC conserved extended haplotypes using families from the United Arab Emirates by Alnaqbi, Halima, Tay, Guan K., Chehadeh, Sarah El Hajj, Alsafar, Habiba

“…Aside from its anthropological relevance, the characterization of the allele frequencies of genes in the human Major Histocompatibility Complex (MHC) and the…”
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Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas by Wang, P, Dong, Q, Zhang, C, Kuan, P-F, Liu, Y, Jeck, W R, Andersen, J B, Jiang, W, Savich, G L, Tan, T-X, Auman, J T, Hoskins, J M, Misher, A D, Moser, C D, Yourstone, S M, Kim, J W, Cibulskis, K, Getz, G, Hunt, H V, Thorgeirsson, S S, Roberts, L R, Ye, D, Guan, K-L, Xiong, Y, Qin, L-X, Chiang, D Y

“…Mutations in the genes encoding isocitrate dehydrogenase, IDH1 and IDH2 , have been reported in gliomas, myeloid leukemias, chondrosarcomas and thyroid cancer…”
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HLA class I associations with the severity of COVID-19 disease in the United Arab Emirates by Tay, Guan K, Alnaqbi, Halima, Chehadeh, Sarah, Peramo, Braulio, Mustafa, Farah, Rizvi, Tahir A, Mahboub, Bassam H, Uddin, Maimunah, Alkaabi, Nawal, Alefishat, Eman, Jelinek, Herbert F, Alsafar, Habiba

“…SARS-CoV-2 appears to induce diverse innate and adaptive immune responses, resulting in different clinical manifestations of COVID-19. Due to their function in…”
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Regulation of glycolysis and gluconeogenesis by acetylation of PKM and PEPCK by Xiong, Y, Lei, Q-Y, Zhao, S, Guan, K-L

“…Glycolysis is a catabolic process of glucose hydrolysis needed for energy and biosynthetic intermediates, whereas gluconeogenesis is a glucose production…”
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Robust features of future climate change impacts on sorghum yields in West Africa by Sultan, B, Guan, K, Kouressy, M, Biasutti, M, Piani, C, Hammer, G L, McLean, G, Lobell, D B

“…West Africa is highly vulnerable to climate hazards and better quantification and understanding of the impact of climate change on crop yields are urgently…”
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Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents by Al-Anouti, Fatme, Mousa, Mira, Karras, Spyridon N, Grant, William B, Alhalwachi, Zainab, Abdel-Wareth, Laila, Uddin, Maimunah, Alkaabi, Nawal, Tay, Guan K, Mahboub, Bassam, AlSafar, Habiba

“…Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in…”
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Analysis of SARS-CoV-2 viral loads in stool samples and nasopharyngeal swabs from COVID-19 patients in the United Arab Emirates by Daou, Mariane, Kannout, Hussein, Khalili, Mariam, Almarei, Mohamed, Alhashami, Mohamed, Alhalwachi, Zainab, Alshamsi, Fatima, Tahseen Al Bataineh, Mohammad, Azzam Kayasseh, Mohd, Al Khajeh, Abdulmajeed, Hasan, Shadi W, Tay, Guan K, Feng, Samuel F, Ruta, Dymitr, Yousef, Ahmed F, Alsafar, Habiba S

“…Coronavirus disease 2019 (COVID-19) was first identified in respiratory samples and was found to commonly cause cough and pneumonia. However, non-respiratory…”
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The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis by Kang, Y J, Lu, M-K, Guan, K-L

“…Tuberous sclerosis complex (TSC)1 and TSC2 are tumor suppressors that inhibit cell growth and mutation of either gene causes benign tumors in multiple tissues…”
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Soil carbon sequestration by three perennial legume pastures is greater in deeper soil layers than in the surface soil by Guan, X.-K, Turner, N. C, Song, L, Gu, Y.-J, Wang, T.-C, Li, F.-M

“…Soil organic carbon (SOC) plays a vital role as both a sink for and source of atmospheric carbon. Revegetation of degraded arable land in China is expected to…”
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KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation by Han, X-R, Zha, Z, Yuan, H-X, Feng, X, Xia, Y-K, Lei, Q-Y, Guan, K-L, Xiong, Y

“…KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional…”
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