Search Results - "Guan, Junhong"

DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity by Lu, Changzheng, Guan, Junhong, Lu, Steve, Jin, Qihuang, Rousseau, Benoit, Lu, Tianshi, Stephens, Dennis, Zhang, Hongyi, Zhu, Jiankun, Yang, Mingming, Ren, Zhenhua, Liang, Yong, Liu, Zhida, Han, Chuanhui, Liu, Longchao, Cao, Xuezhi, Zhang, Anli, Qiao, Jian, Batten, Kimberly, Chen, Mingyi, Castrillon, Diego H., Wang, Tao, Li, Bo, Diaz, Luis A., Li, Guo-Min, Fu, Yang-Xin

“…Increased neoantigens in hypermutated cancers with DNA mismatch repair deficiency (dMMR) are proposed as the major contributor to the high objective response…”
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NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage by Guan, Junhong, Yu, Shuyu, Zheng, Xiaofeng

“…NEDDylation has been shown to participate in the DNA damage pathway, but the substrates of neural precursor cell expressed developmentally downregulated 8…”
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Osthole prevents cerebral ischemia-reperfusion injury via the Notch signaling pathway by Guan, Junhong, Wei, Xiangtai, Qu, Shengtao, Lv, Tao, Fu, Qiang, Yuan, Ye

“…Stroke is a common cerebrovascular disease in aging populations, and constitutes the second highest principle cause of mortality and the principle cause of…”
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NEDDylation regulates RAD18 ubiquitination and localization in response to oxidative DNA damage by Guan, Junhong, Zheng, Xiaofeng

“…Genome integrity is important for cell growth, development and proliferation. The E3 ligase RAD18 plays a vital role in the DNA damage response (DDR) to…”
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Identification of microRNAs as novel biomarkers for glioma detection: A meta-analysis based on 11 articles by Qu, Shengtao, Guan, Junhong, Liu, Yunhui

“…Abstract Background Glioma is the most common and lethal primary brain tumors, and is regarded as one of the deadliest of human cancers. To date, a growing…”
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Imaging Analysis of Primary Malignant Intracranial Lymphoma by Chen, Duo, Fan, Guoguang, Guan, Junhong, Liu, Yunhui

“…OBJECTIVE To investigate the images characteristics of primary malignant intracranial lymphoma. METHODS Retrospective study was conducted on CT/MRI imaging…”
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RNF168-mediated H2A neddylation antagonizes ubiquitylation of H2A and regulates DNA damage repair by Li, Tingting, Guan, Junhong, Huang, Ziji, Hu, Xiang, Zheng, Xiaofeng

“…NEDD8 is an important regulatory factor in many biological processes. However, the substrates for neddylation, and the relationship between the ubiquitin and…”
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MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway by Guan, Junhong, Lu, Changzheng, Jin, Qihuang, Lu, Huiming, Chen, Xiang, Tian, Lei, Zhang, Yanbin, Ortega, Janice, Zhang, Junqiu, Siteni, Silvia, Chen, Mingyi, Gu, Liya, Shay, Jerry W., Davis, Anthony J., Chen, Zhijian J., Fu, Yang-Xin, Li, Guo-Min

“…Tumors with defective mismatch repair (dMMR) are responsive to immunotherapy because of dMMR-induced neoantigens and activation of the cGAS-STING pathway…”
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MyD88 NEDDylation negatively regulates MyD88-dependent NF-κB signaling through antagonizing its ubiquitination by Yan, Fangxue, Guan, Junhong, Peng, Yanyan, Zheng, Xiaofeng

“…Myeloid differentiation factor 88 (MyD88) plays a central role in innate immunity response, however, how its activity is tightly regulated remains largely…”
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The Microscopic Surgical Treatment for Tumor of Posterior Cranial Fossa in Children by Chen, Duo, Wei, Xiangtai, Yin, Qiang, Guan, Junhong, Pan, Weiran, Wang, Chenglin, Liu, Yunhui

“…OBJECTIVE To analyze and discuss about the clinical characteristics, pathological types, surgical modalities and techniques, and postoperative complications in…”
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The herpes simplex virus 1 UL36USP deubiquitinase suppresses DNA repair in host cells via deubiquitination of proliferating cell nuclear antigen by Dong, Xiaodong, Guan, Junhong, Zheng, Chunfu, Zheng, Xiaofeng

“…Herpes simplex virus 1 (HSV-1) infection manipulates distinct host DNA-damage responses to facilitate virus proliferation, but the molecular mechanisms remain…”
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LncRNA UCA1 sponges miR-204-5p to promote migration, invasion and epithelial-mesenchymal transition of glioma cells via upregulation of ZEB1 by Liang, Chao, Yang, Yang, Guan, Junhong, Lv, Tao, Qu, Shengtao, Fu, Qiang, Zhao, Hongyu

“…Long non-coding RNA urothelial carcinoma associated 1 (lncRNA UCA1) promotes cancer progression and enhances chemoresistance through miR-204-5p in a few…”
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Targeting UBE2T Potentiates Gemcitabine Efficacy in Pancreatic Cancer by Regulating Pyrimidine Metabolism and Replication Stress by Jiang, Xiangyan, Ma, Yong, Wang, Tao, Zhou, Huinian, Wang, Keshen, Shi, Wengui, Qin, Long, Guan, Junhong, Li, Lianshun, Long, Bo, Wang, Jianli, Guan, Xiaoying, Ye, Huili, Yang, Jing, Yu, Zeyuan, Jiao, Zuoyi

“…Although small patient subsets benefit from current targeted strategies or immunotherapy, gemcitabine remains the first-line drug for pancreatic cancer (PC)…”
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DNA mismatch repair in cancer immunotherapy by Guan, Junhong, Li, Guo-Min

“…Abstract Tumors defective in DNA mismatch repair (dMMR) exhibit microsatellite instability (MSI). Currently, patients with dMMR tumors are benefitted from…”
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PICH Activates Cyclin A1 Transcription to Drive S-Phase Progression and Chemoresistance in Gastric Cancer by Ye, Huili, Shi, Wengui, Yang, Jing, Wang, Long, Jiang, Xiangyan, Zhao, Huiming, Qin, Long, Qin, Junjie, Li, Lianshun, Cai, Weiwen, Guan, Junhong, Yang, Hanteng, Zhou, Huinian, Yu, Zeyuan, Sun, Hui, Jiao, Zuoyi

“…The chemotherapeutic agent 5-fluorouracil (5-FU) remains the backbone of postoperative adjuvant treatment for gastric cancer. However, fewer than half of…”
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Atorvastatin suppresses NLRP3 inflammasome activation in intracerebral hemorrhage via TLR4- and MyD88-dependent pathways by Chen, Duo, Sui, Lu, Chen, Cao, Liu, Sanchuan, Sun, Xianfeng, Guan, Junhong

“…Intracerebral hemorrhage (ICH) is a common neurological condition that causes severe disability and even death. Even though the mechanism is not clear,…”
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Mutant huntingtin protein induces MLH1 degradation, DNA hyperexcision, and cGAS-STING-dependent apoptosis by Sun, Xiao, Liu, Lu, Wu, Chao, Li, Xueying, Guo, Jinzhen, Zhang, Junqiu, Guan, Junhong, Wang, Nan, Gu, Liya, Yang, X Willian, Li, Guo-Min

“…Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin ( ) gene. The repeat-expanded encodes a…”
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DNA-PKcs-dependent phosphorylation of RECQL4 promotes NHEJ by stabilizing the NHEJ machinery at DNA double-strand breaks by Lu, Huiming, Guan, Junhong, Wang, Shih-Ya, Li, Guo-Min, Bohr, Vilhelm A, Davis, Anthony J

“…Abstract Non-homologous end joining (NHEJ) is the major pathway that mediates the repair of DNA double-strand breaks (DSBs) generated by ionizing radiation…”
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Bone morphogenetic protein-7 (BMP-7) mediates ischemic preconditioning-induced ischemic tolerance via attenuating apoptosis in rat brain by Guan, Junhong, Li, Han, Lv, Tao, Chen, Duo, Yuan, Ye, Qu, Shengtao

“…•BMP-7 expression increased in rat brain after ischemic preconditioning (IPC).•Inhibiting BMP-7 by noggin or siRNA weakened IPC-induced neuroprotection.•BMP-7…”
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Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway by Yu, Mingjun, Yu, Shijia, Gong, Wei, Chen, Duo, Guan, Junhong, Liu, Yunhui

“…LncRNAs have been proved to be involved in the promotion of glioma cell malignant development. However, the exact roles and molecular mechanisms of linc01023…”
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