Search Results - "Guan, Huaijin"

Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocycline by Chen, Wei, Zhao, Minjie, Zhao, Shuzhi, Lu, Qianyi, Ni, Lisha, Zou, Chen, Lu, Li, Xu, Xun, Guan, Huaijin, Zheng, Zhi, Qiu, Qinghua

“…Objective and design Chronic low-grade inflammation occurs in diabetic retinopathy (DR), but the underlying mechanism(s) remains (remain) unclear. NLRP3…”
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Hydroxycamptothecin regulates scar formation of the filtration channel under scleral flap by inhibiting the proliferation of scleral fibroblasts by Gu, Hongwei, Liang, Ya, Shen, Yao, Shuai, Jie, Yu, Qiuli, Guan, Huaijin, Yuan, Zhilan

“…To investigate the inhibitory effect of a hyaluronic acid hydrogel loaded with hydroxycamptothecin (HCPT) on scar formation after filtration surgery in a…”
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CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract by Liu, Junliang, Zhang, Jinling, Zhang, Guowei, Zhou, Tianqiu, Zou, Xi, Guan, Huaijin, Wang, Yong

“…Ultraviolet B (UVB) irradiation could trigger DNA double-strand breaks (DDSBs) and senescence in lens epithelial cells (LECs), thus inducing age-related…”
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Allelic interaction effects of DNA damage and repair genes on the predisposition to age-related cataract by Yang, Mei, Zhang, Junfang, Su, Shu, Qin, Bai, Kang, Lihua, Zhu, Rongrong, Guan, Huaijin

“…Age-related cataract (ARC) is a leading cause of visual impairment and blindness worldwide. DNA damage and malfunction of DNA repair are believed to contribute…”
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ATP-P2X7R-mediated microglia senescence aggravates retinal ganglion cell injury in chronic ocular hypertension by Wei, Miao, Zhang, Guowei, Huang, Zeyu, Ding, Xuemeng, Sun, Qing, Zhang, Yujian, Zhu, Rongrong, Guan, Huaijin, Ji, Min

“…Abstract Background Dysfunction of microglia during aging affects normal neuronal function and results in the occurrence of neurodegenerative diseases. Retinal…”
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Evaluation of Fundus Function in Mature Cataract Patients by Visual Electrophysiology by Zhang, Min, Ji, Min, Tan, Mengjia, Yu, Ying, Guan, Huaijin

“…Purpose. To explore the value of visual electrophysiology in evaluating the fundus function of mature cataract patients. Methods. 124 mature cataract patients…”
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A systematic evaluation of microRNAs in regulating human hepatic CYP2E1 by Wang, Yong, Yu, Dianke, Tolleson, William H., Yu, Li-Rong, Green, Bridgett, Zeng, Linjuan, Chen, Yinting, Chen, Si, Ren, Zhen, Guo, Lei, Tong, Weida, Guan, Huaijin, Ning, Baitang

“…[Display omitted] Cytochrome P450 2E1 (CYP2E1) is an important drug metabolizing enzyme for processing numerous xenobiotics in the liver, including…”
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Efficacy and comfort following the implantation of extended depth of focus, multifocal, and monofocal intraocular lenses in cataract patients by Wang, Junhui, Luo, Jiawei, Yang, Wenyu, Ren, Ruoxin, Xie, Yi, Li, Jiaxin, Guan, Huaijin, Ji, Min

“…Extended depth of focus (EDOF) and multifocal (Multi) intraocular lenses (IOL) can provide a fixed distance of near vision, which may result in some discomfort…”
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Altered DNA Methylation and Expression Profiles of 8-Oxoguanine DNA Glycosylase 1 in Lens Tissue from Age-related Cataract Patients by Wang, Yong, Li, Fei, Zhang, Guowei, Kang, Lihua, Qin, Bai, Guan, Huaijin

“…Purpose: Oxidative stress and DNA damage contribute to the pathogenesis of age-related cataract (ARC). Most oxidative DNA lesions are repaired via the base…”
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Distinct macular thickness changes after femtosecond laser–assisted cataract surgery of age-related cataract and myopia with cataract by Wang, Yong, Du, Jun, Yang, Mei, Xu, Yi, Guan, Huaijin, Wu, Jian

“…Cataract surgery can cause macular thickness change. We used optical coherence tomography (OCT) to assess the macular thickness of different regions after…”
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Prevalence of Vision Impairment in Older Adults in Rural China: The China Nine-Province Survey by JIALIANG ZHAO, ELLWEIN, Leon B, HU LIU, HAO CUI, JIAN GE, HUAIJIN GUAN, JIANHUA LV, XIANZHI MA, JINGLIN YIN, ZHENG QIN YIN, YUANSHENG YUAN

“…Describe the prevalence of visual impairment/blindness among older adults in rural populations in China. Population-based, cross-sectional study. We evaluated…”
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Influence of angle alpha on visual quality after implantation of extended depth of focus intraocular lenses by Qin, Miaomiao, Ji, Min, Zhou, Tianqiu, Yuan, Yurong, Luo, Jiawei, Li, Pengfei, Wang, Ying, Chen, Xiaojuan, Chen, Wei, Guan, Huaijin

“…To assess postoperative changes in angle alpha, and to evaluate the postoperative visual quality of patients with different angle alpha values after…”
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Comparison of preoperative angle kappa measurements in the eyes of cataract patients obtained from Pentacam Scheimpflug system, optical low-coherence reflectometry, and ray-tracing aberrometry by Qin, Miaomiao, Yuan, Yurong, Wang, Ying, Li, Pengfei, Chen, Wei, Wang, Yong, Yang, Mei, Wu, Jian, Ji, Min, Luo, Jiawei, Tang, Jiamin, Chen, Xiaojuan, Huang, Yemeng, Guan, Huaijin

“…Angle kappa plays a vital role in the implantation of multifocal intraocular lens (MIOL). Large angle kappa is related to a higher risk of postoperative photic…”
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Lens epithelium cell ferroptosis mediated by m6A-lncRNA and GPX4 expression in lens tissue of age-related cataract by Wang, Yong, Li, Pengfei, Wang, Congyu, Bao, Sijie, Wang, Siwen, Zhang, Guowei, Zou, Xi, Wu, Jian, Guan, Yu, Ji, Min, Guan, Huaijin

“…Abstract Background In the present study, we explored the role of N 6 -methyladenosine (m 6 A) modification of long non-coding RNAs (lncRNAs) and its…”
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An Ex Vivo Study on Release, Uptake, and miRNA Profile of Exosomes in Rat Lens by Zhang, Junfang, Luo, Jiawei, Zhang, Guowei, Qin, Bai, Ren, Xiumei, Guan, Huaijin

“…Purpose. To identify the ability of releasing and uptaking exosomes in rat lens and characterize the exosomal microRNA profile of lens-derived exosomes…”
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Effect of Anterior Chamber Instability during Phacoemulsification Combined with Intraocular Lens Implantation by Geng, Wenjing, Lin, Wenli, Song, Pei, Zhang, Min, Wu, Jian, Su, Shu, Yuan, Yurong, Ji, Min, Guan, Huaijin

“…Purpose. To determine the incidence of anterior chamber (AC) instability during phacoemulsification (phaco) combined with intraocular lens implantation and…”
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Primary Angle Closure and Sequence Variants within MicroRNA Binding Sites of Genes Involved in Eye Development by Shi, Haihong, Zhang, Junfang, Zhu, Rongrong, Hu, Nan, Lu, Hong, Yang, Mei, Qin, Bai, Shi, Jian, Guan, Huaijin

“…The formation of primary angle closure (PAC) and primary angle closure glaucoma (PACG) is regulated by a tissue remodeling pathway that plays a critical role…”
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Comparison of optical quality and distinct macular thickness in femtosecond laser-assisted versus phacoemulsification cataract surgery by Wang, Yong, Zhang, Jinling, Qin, Miaomiao, Miao, Jianguo, Chen, Wei, Huang, Yemeng, Wu, Jian, Guan, Yu, Guan, Huaijin

“…Optical quality and macular thickness changing optical quality is rarely reported after femtosecond laser-assisted cataract surgery (FLACS). In current…”
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Prevalence and Outcomes of Cataract Surgery in Rural China: The China Nine-Province Survey by JIALIANG ZHAO, ELLWEIN, Leon B, HU LIU, HAO CUI, JIAN GE, HUAIJIN GUAN, JIANHUA LV, XIANZHI MA, JINGLIN YIN, ZHENG QIN YIN, YUANSHENG YUAN

“…To investigate the prevalence and visual acuity (VA) outcomes of cataract surgery in rural populations throughout China. Population-based, cross-sectional…”
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Genetic variants in PVRL2-TOMM40-APOE region are associated with human longevity in a Han Chinese population by Lu, Fang, Guan, Huaijin, Gong, Bo, Liu, Xiaoqi, Zhu, Rongrong, Wang, Yong, Qian, Jingjing, Zhou, Tianqiu, Lan, Xiaoyan, Wang, Pu, Lin, Ying, Ma, Shi, Lin, He, Zhu, Xiong, Chen, Rong, Zhu, Xianjun, Shi, Yi, Yang, Zhenglin

“…Human longevity results from a number of factors, including genetic background, favorable environmental, social factors and chance. In this study, we aimed to…”
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