Search Results - "Guan, Guiwen"

E2F1‐mediated AUF1 upregulation promotes HCC development and enhances drug resistance via stabilization of AKR1B10 by Zhang, Ting, Guan, Guiwen, Zhang, Jing, Zheng, Huiling, Li, Deyao, Wang, Wengong, Lu, Fengmin, Chen, Xiangmei

“…The AU‐rich binding factor 1 (AUF1) is one of the well known adenylate‐uridylate‐rich element (ARE)‐specific RNA‐binding proteins (ARE‐BPs) for which…”
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NFATc3 inhibits hepatocarcinogenesis and HBV replication via positively regulating RIG-I-mediated interferon transcription by Zao, Xiaobin, Cheng, Jin, Shen, Congle, Guan, Guiwen, Feng, Xiaoyu, Zou, Jun, Zhang, Jing, Liu, Tianxu, Zheng, Huiling, Zhang, Ting, Wang, Jie, Liu, Jia, Li, Deyao, Lu, Fengmin, You, Fuping, Chen, Xiangmei

“…Nuclear factor of activated T cells 3 (NFATc3) has been reported to upregulate type I interferons (IFNs) expression, and the abnormal expression and activation…”
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Cell Cycle Arrest Protein CDKN2C Is Not an HBV Host Factor by Guan, Guiwen, Zheng, Liwei, Xi, Jingyuan, Yang, Xingwen, Chen, Xiangmei, Lu, Fengmin

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Pacbio Sequencing of PLC/PRF/5 Cell Line and Clearance of HBV Integration Through CRISPR/Cas-9 System by Chen, Chia-Chen, Guan, Guiwen, Qi, Xuewei, Abulaiti, Abudurexiti, Zhang, Ting, Liu, Jia, Lu, Fengmin, Chen, Xiangmei

“…The integration of HBV DNA is one of the carcinogenic mechanisms of HBV. The clearance of HBV integration in hepatocyte is of great significance to cure…”
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RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation by Zhang, Ting, Zheng, Huiling, Lu, Danjuan, Guan, Guiwen, Li, Deyao, Zhang, Jing, Liu, Shuhong, Zhao, Jingmin, Guo, Ju-Tao, Lu, Fengmin, Chen, Xiangmei

“…The pregenomic RNA (pgRNA) of hepatitis B virus (HBV) serves not only as a bicistronic message RNA to translate core protein (Cp) and DNA polymerase (Pol), but…”
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Hepatitis B virus enhancer 1 activates preS1 and preS2 promoters of integrated HBV DNA impairing HBsAg secretion by Gu, Zhiqiang, Jiang, Qianqian, Abulaiti, Abudurexiti, Chen, Xiaojie, Li, Mingwei, Gao, Na, Guan, Guiwen, Zhang, Ting, Yang, Danli, Xi, Jingyuan, Yu, Guangxin, Liu, Shuhong, Zhu, Zhijun, Gao, Zhiliang, Zhao, Jingmin, Huang, Hongxin, Chen, Xiangmei, Lu, Fengmin

“…The expression of HBsAg from integrated HBV DNA limits the achievement of functional cure for chronic hepatitis B. Thus, characterising the unique expression…”
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Editorial: HBsAg seroclearance after pegylated interferon treatment—The beginning of the end. Authors' reply by Gao, Na, Guan, Guiwen, Zhao, Qiyi, Gao, Zhiliang

“…LINKED CONTENT This article is linked to Gao et al papers. To view these articles, visit https://doi.org/10.1111/apt.17670 and https://doi.org/10.1111/apt.17690…”
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A global survey of alternative splicing of HBV transcriptome using long-read sequencing by Guan, Guiwen, Zou, Jun, Zhang, Ting, Lu, Fengmin, Chen, Xiangmei

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Notoamide-type alkaloid induced apoptosis and autophagy via a P38/JNK signaling pathway in hepatocellular carcinoma cells by Hu, Likun, Zhang, Ting, Liu, Dong, Guan, Guiwen, Huang, Jian, Proksch, Peter, Chen, Xiangmei, Lin, Wenhan

“…Bioassay-guided fractionation of a coral-associated fungus LZDX-32-15 resulted in the isolation of eleven notoamide-type alkaloids, including four new…”
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A global survey of alternative splicing of HBV transcriptome using long-read sequencing / Reply by Guan, Guiwen, Zou, Jun, Zhang, Ting, Lu, Fengmin, Chen, Xiangmei, Yuan, Shilin, Yang, Yuedong, Hu, Ronggui

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An Immunocompetent Mongolian Gerbil Model for Hepatitis E Virus Genotype 1 Infection by Liu, Tianxu, He, Qiyu, Yang, Xinyue, Li, Yuebao, Yuan, Disen, Lu, Qinghui, Tang, Tianyu, Guan, Guiwen, Zheng, Liwei, Zhang, He, Xia, Changyou, Yin, Xin, Wei, Guochao, Chen, Xiangmei, Lu, Fengmin, Wang, Lin

“…Hepatitis E virus (HEV), primarily genotype 1 (HEV-1), causes approximately 20.1 million infections, 44,000 deaths, and 3000 stillbirths annually. Current…”
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Integrated HBV DNA and cccDNA maintain transcriptional activity in intrahepatic HBsAg ‐positive patients with functional cure following PEG‐IFN ‐based therapy by Gao, Na, Guan, Guiwen, Xu, Ganlin, Wu, Haishi, Xie, Chan, Mo, Zhishuo, Deng, Hong, Xiao, Shuying, Deng, Zhicong, Peng, Liang, Lu, Fengmin, Zhao, Qiyi, Gao, Zhiliang

“…Summary Background Hepatitis B surface antigen (HBsAg) seroclearance marks regression of hepatitis B virus (HBV) infection. However, more than one‐fifth of…”
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LncCDCA3L inhibits cell proliferation via a novel RNA structure‐based crosstalk with CDCA3 in hepatocellular carcinoma by Wang, Yongfeng, Liu, Yongzhen, Zhang, Ting, Guan, Guiwen, Mao, Tianhao, Liu, Hui, Zhang, Jing, Lu, Fengmin, Chen, Xiangmei

“…Background & Aims The molecular mechanisms underlying hepatocellular carcinoma (HCC) remain poorly understood. In this study, we investigated cell division…”
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The A1762T/G1764A mutations enhance HBV replication by alternating viral transcriptome by Yang, Danli, Zou, Jun, Guan, Guiwen, Feng, Xiaoyu, Zhang, Ting, Li, Guixin, Liu, Hui, Zheng, Huiling, Xi, Jingyuan, Yu, Guangxin, Dai, Lizhong, Lu, Fengmin, Chen, Xiangmei

“…The A1762T/G1764A mutations, one of the most common mutations in the hepatitis B virus basal core promoter, are associated with the progression of chronic HBV…”
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Long‐term antiviral therapy is associated with changes in the profile of transcriptionally active HBV integration in the livers of patients with CHB by Wen, Xiajie, Wu, Xiaoning, Sun, Yameng, Zhou, Jialing, Guan, Guiwen, Chen, Shuyan, Shan, Shan, Ma, Hong, Zhao, Xinyan, Wang, Yu, Ou, Xiaojuan, You, Hong, Guo, Ju‐Tao, Lu, Fengmin, Jia, Jidong

“…Hepatitis B virus (HBV) integration exists throughout the clinical course of chronic hepatitis B (CHB). This study investigated the effects of long‐term…”
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Multi‐omics panoramic analysis of HBV integration, transcriptional regulation, and epigenetic modifications in PLC/PRF/5 cell line by Guan, Guiwen, Abulaiti, Abudurexiti, Qu, Chenxiao, Chen, Chia‐Chen, Gu, Zhiqiang, Yang, Jing, Zhang, Ting, Chen, Xiaojie, Zhou, Zhao, Lu, Fengmin, Chen, Xiangmei

“…The clearance or transcriptional silencing of integrated HBV DNA is crucial for achieving a functional cure in patients with chronic hepatitis B and reducing…”
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Higher TP53BP2 expression is associated with HBsAg loss in peginterferon-α-treated patients with chronic hepatitis B by Guan, Guiwen, Zhang, Ting, Ning, Jing, Tao, Changyu, Gao, Na, Zeng, Zhenzhen, Guo, Huili, Chen, Chia-Chen, Yang, Jing, Zhang, Jing, Gu, Weilin, Yang, Ence, Liu, Ren, Guo, Xiaosen, Ren, Shan, Wang, Lin, Wei, Guochao, Zheng, Sujun, Gao, Zhiliang, Chen, Xinyue, Lu, Fengmin, Chen, Xiangmei

“…HBsAg loss is only observed in a small proportion of patients with chronic hepatitis B (CHB) who undergo interferon treatment. Investigating the host factors…”
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AUF1 promotes hepatocellular carcinoma progression and chemo-resistance by post-transcriptionally upregulating alpha-fetoprotein expression by Zhang, Jing, Zhang, Ting, Guan, Guiwen, Wen, Jiyun, Chen, Chia-Chen, Liu, Jia, Duan, Yuan, Liu, Yanna, Chen, Xiangmei

“…The target genes of AU-rich Element RNA-binding Protein 1 (AUF1), which is an RNA binding protein, and its role in the progression of hepatocellular carcinoma…”
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Sex-determining region Y box 4 (SOX4) suppresses Hepatitis B virus replication by inhibiting hepatocyte nuclear factor 4α expression by Shi, Shu, Liu, Mingchen, Xi, Jingyuan, Liu, Hui, Guan, Guiwen, Shen, Congle, Guo, Zhengyang, Zhang, Ting, Xu, Qiang, Kudereti, Dilidaer, Chen, Xiangmei, Wang, Jie, Lu, Fengmin

“…Hepatitis B virus (HBV) infection is still a health care crisis in the world, and a considerable number of chronic hepatitis B patients die of end-stage liver…”
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The gRNA-miRNA-gRNA Ternary Cassette Combining CRISPR/Cas9 with RNAi Approach Strongly Inhibits Hepatitis B Virus Replication by Wang, Jie, Chen, Ran, Zhang, Ruiyang, Ding, Shanlong, Zhang, Tianying, Yuan, Quan, Guan, Guiwen, Chen, Xiangmei, Zhang, Ting, Zhuang, Hui, Nunes, Frederick, Block, Timothy, Liu, Shuang, Duan, Zhongping, Xia, Ningshao, Xu, Zhongwei, Lu, Fengmin

“…The CRISPR/Cas9 system is a novel genome editing technology which has been successfully used to inhibit HBV replication. Here, we described a novel…”
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