Search Results - "Guaglianone, Gretchen"

Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by β‑Hairpins Derived from Aβ by Haerianardakani, Sepehr, Kreutzer, Adam G, Salveson, Patrick J, Samdin, Tuan D, Guaglianone, Gretchen E, Nowick, James S

“…Oligomers of the β-amyloid peptide, Aβ, play a central role in the pathogenesis and progression of Alzheimer’s disease. Trimers and higher-order oligomers…”
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Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer’s Disease and Associated Amyloid-Disease Brain Tissue by Kreutzer, Adam G., Parrocha, Chelsea Marie T., Haerianardakani, Sepehr, Guaglianone, Gretchen, Nguyen, Jennifer T., Diab, Michelle N., Yong, William, Perez-Rosendahl, Mari, Head, Elizabeth, Nowick, James S.

“…Antibodies that target the β-amyloid peptide (Aβ) and its associated assemblies are important tools in Alzheimer’s disease research and have emerged as…”
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Isobactins: -acyl isopeptide prodrugs of teixobactin and teixobactin derivatives by Jones, Chelsea R, Guaglianone, Gretchen, Lai, Grant H, Nowick, James S

“…The antibiotic teixobactin is a promising drug candidate against drug-resistant pathogens, such as MRSA and VRE, but forms insoluble gels that may limit…”
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Applying New Tools to Study Aβ-Derived Oligomers by Guaglianone, Gretchen

“…The formation of aggregates of the amyloidogenic peptide β-amyloid (Aβ), termed oligomers, is central to Alzheimer’s disease, where oligomers play a central…”
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Isobactins: O -acyl isopeptide prodrugs of teixobactin and teixobactin derivatives by Jones, Chelsea R, Guaglianone, Gretchen, Lai, Grant H, Nowick, James S

“…The antibiotic teixobactin is a promising drug candidate against drug-resistant pathogens, such as MRSA and VRE, but forms insoluble gels that may limit…”
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Synthesis and study of macrocyclic β-hairpin peptides for investigating amyloid oligomers by Guaglianone, Gretchen, Kreutzer, Adam G, Nowick, James S

“…Chemically constrained peptides that self-assemble can be used to better understand the molecular basis of amyloid diseases. The formation of small assemblies…”
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Converting an Organic Chemistry Course to an Online Format in Two Weeks: Design, Implementation, and Reflection by Howitz, William J, Guaglianone, Gretchen, King, Susan M

“…As the SARS-CoV-2 pandemic spread throughout the world, universities were faced with extraordinary challenges. Shelter-in-place orders were given, in-person…”
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A cyclic peptide inhibitor of the SARS-CoV-2 main protease by Kreutzer, Adam G., Krumberger, Maj, Diessner, Elizabeth M., Parrocha, Chelsea Marie T., Morris, Michael A., Guaglianone, Gretchen, Butts, Carter T., Nowick, James S.

“…This paper presents the design and study of a first-in-class cyclic peptide inhibitor against the SARS-CoV-2 main protease (Mpro). The cyclic peptide inhibitor…”
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A β-barrel-like tetramer formed by a β-hairpin derived from Aβ by Samdin, Tuan D, Jones, Chelsea R, Guaglianone, Gretchen, Kreutzer, Adam G, Freites, J. Alfredo, Wierzbicki, Micha, Nowick, James S

“…β-Hairpins formed by the β-amyloid peptide Aβ are building blocks of Aβ oligomers. Three different alignments of β-hairpins have been observed in the…”
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Probing differences among Aβ oligomers with two triangular trimers derived from Aβ by Kreutzer, Adam G, Guaglianone, Gretchen, Yoo, Stan, Parrocha, Chelsea Marie T, Ruttenberg, Sarah M, Malonis, Ryan J, Tong, Karen, Lin, Yu-Fu, Nguyen, Jennifer T, Howitz, William J, Diab, Michelle N, Hamza, Imane L, Lai, Jonathan R, Wysocki, Vicki H, Nowick, James S

“…The assembly of the β-amyloid peptide (Aβ) to form oligomers and fibrils is closely associated with the pathogenesis and progression of Alzheimer's disease. Aβ…”
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Correction to “Expression of N‑Terminal Cysteine Aβ42 and Conjugation to Generate Fluorescent and Biotinylated Aβ42” by Zhang, Sheng, Guaglianone, Gretchen, Morris, Michael A, Yoo, Stan, Howitz, William J, Xing, Li, Zheng, Jian-Guo, Jusuf, Hannah, Huizar, Grace, Lin, Jonathan, Kreutzer, Adam G, Nowick, James S

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Correction to "Expression of N-Terminal Cysteine Aβ 42 and Conjugation to Generate Fluorescent and Biotinylated Aβ 42 " by Zhang, Sheng, Guaglianone, Gretchen, Morris, Michael A, Yoo, Stan, Howitz, William J, Xing, Li, Zheng, Jian-Guo, Jusuf, Hannah, Huizar, Grace, Lin, Jonathan, Kreutzer, Adam G, Nowick, James S

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Expression of N-Terminal Cysteine Aβ 42 and Conjugation to Generate Fluorescent and Biotinylated Aβ 42 by Zhang, Sheng, Guaglianone, Gretchen, Morris, Michael A, Yoo, Stan, Howitz, William J, Xing, Li, Zheng, Jian-Guo, Jusuf, Hannah, Huizar, Grace, Lin, Jonathan, Kreutzer, Adam G, Nowick, James S

“…Fluorescent derivatives of the β-amyloid peptides (Aβ) are valuable tools for studying the interactions of Aβ with cells. Facile access to labeled expressed Aβ…”
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X‑ray Crystallography Reveals Parallel and Antiparallel β‑Sheet Dimers of a β‑Hairpin Derived from Aβ16–36 that Assemble to Form Different Tetramers by Kreutzer, Adam G, Samdin, Tuan D, Guaglianone, Gretchen, Spencer, Ryan K, Nowick, James S

“…High-resolution structures of oligomers formed by the β-amyloid peptide, Aβ, are important for understanding the molecular basis of Alzheimer’s disease. Dimers…”
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Expression of N‑Terminal Cysteine Aβ42 and Conjugation to Generate Fluorescent and Biotinylated Aβ42 by Zhang, Sheng, Guaglianone, Gretchen, Morris, Michael A, Yoo, Stan, Howitz, William J, Xing, Li, Zheng, Jian-Guo, Jusuf, Hannah, Huizar, Grace, Lin, Jonathan, Kreutzer, Adam G, Nowick, James S

“…Fluorescent derivatives of the β-amyloid peptides (Aβ) are valuable tools for studying the interactions of Aβ with cells. Facile access to labeled expressed Aβ…”
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Elucidating the Oligomerization and Cellular Interactions of a Trimer Derived from Aβ through Fluorescence and Mass Spectrometric Studies by Guaglianone, Gretchen, Torrado, Belén, Lin, Yu-Fu, Watkins, Matthew C., Wysocki, Vicki H., Gratton, Enrico, Nowick, James S.

“…Aβ oligomers play a central role in the neurodegeneration observed with Alzheimer’s disease. Our laboratory has developed covalently stabilized trimers derived…”
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Macrocyclic Peptides Derived from Familial Alzheimer’s Disease Mutants Show Charge-Dependent Oligomeric Assembly and Toxicity by Howitz, William J, Guaglianone, Gretchen, McKnelly, Kate J, Haduong, Katelyn, Ashby, Shareen N, Laayouni, Mohamed, Nowick, James S

“…This work probes the role of charge in the oligomeric assembly, toxicity, and membrane destabilization of a series of peptides derived from Aβ and the E22Q and…”
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X-ray Crystallography Reveals Parallel and Antiparallel β-Sheet Dimers of a β-Hairpin Derived from Aβ 16-36 that Assemble to Form Different Tetramers by Kreutzer, Adam G, Samdin, Tuan D, Guaglianone, Gretchen, Spencer, Ryan K, Nowick, James S

“…High-resolution structures of oligomers formed by the β-amyloid peptide, Aβ, are important for understanding the molecular basis of Alzheimer's disease. Dimers…”
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Generation and study of antibodies against two triangular trimers derived from Aβ by Kreutzer, Adam G., Malonis, Ryan J., Parrocha, Chelsea Marie T., Tong, Karen, Guaglianone, Gretchen, Nguyen, Jennifer T., Diab, Michelle N., Lai, Jonathan R., Nowick, James S.

“…Monoclonal antibodies (mAbs) that target the β‐amyloid peptide (Aβ) are important Alzheimer's disease research tools and are now being used as Alzheimer's…”
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