Search Results - "Guadagno, Thomas M"

A Survivin-Ran Complex Regulates Spindle Formation in Tumor Cells by Xia, Fang, Canovas, Pedro M., Guadagno, Thomas M., Altieri, Dario C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A novel role for Cdk1/cyclin B in regulating B-raf activation at mitosis by Borysov, Sergiy I, Guadagno, Thomas M

“…MAPK activity is important during mitosis for spindle assembly and maintenance of the spindle checkpoint arrest. We previously identified B-Raf as a critical…”
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A Requirement for MAP Kinase in the Assembly and Maintenance of the Mitotic Spindle by Horne, Melinda M., Guadagno, Thomas M.

“…Circumstantial evidence has suggested the possibility of microtubule-associated protein (MAP) kinase's involvement in spindle regulation. To test this…”
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A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression by Guadagno, Thomas M., Ohtsubo, Motoaki, Roberts, James M., Assoian, Richard K.

“…Cell adhesion has an essential role in regulating proliferation during the G$_1$ phase of the cell cycle, and loss of this adhesion requirement is a classic…”
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B-Raf Is Critical For MAPK Activation during Mitosis and Is Regulated in an M Phase-dependent Manner in Xenopus Egg Extracts by Borysov, Sergiy I., Cheng, Anthony W.M., Guadagno, Thomas M.

“…Activation of the MAPK cascade during mitosis is critical for spindle assembly and normal mitotic progression. The underlying regulatory mechanisms that…”
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Oncogenic B-Raf(V600E) induces spindle abnormalities, supernumerary centrosomes, and aneuploidy in human melanocytic cells by Cui, Yongping, Borysova, Meghan K, Johnson, Joseph O, Guadagno, Thomas M

“…Activating B-Raf mutations arise in 60% to 70% of human melanomas and are thought to play a vital role in tumorigenesis, although how this occurs remains…”
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Degradation of the Human Mitotic Checkpoint Kinase Mps1 Is Cell Cycle-regulated by APC-cCdc20 and APC-cCdh1 Ubiquitin Ligases by Cui, Yongping, Cheng, Xiaolong, Zhang, Ce, Zhang, Yanyan, Li, Shujing, Wang, Chuangui, Guadagno, Thomas M.

“…Mps1 is a dual specificity protein kinase with key roles in regulating the spindle assembly checkpoint and chromosome-microtubule attachments. Consistent with…”
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Cdk2 Kinase Is Required for Entry into Mitosis as a Positive Regulator of Cdc2–Cyclin B Kinase Activity by Guadagno, Thomas M, Newport, John W

“…In higher eukaryotes, Cdk2 kinase plays an essential role in regulating the G1–S transition. Here, we use cycling Xenopus egg extracts to examine the…”
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Oncogenic B-RafV600E Induces Spindle Abnormalities, Supernumerary Centrosomes, and Aneuploidy in Human Melanocytic Cells by YONGPING CUI, BORYSOVA, Meghan K, JOHNSON, Joseph O, GUADAGNO, Thomas M

“…Abstract Activating B-Raf mutations arise in 60% to 70% of human melanomas and are thought to play a vital role in tumorigenesis, although how this occurs…”
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Functional analysis of survivin in spindle assembly in Xenopus egg extracts by Canovas, Pedro M., Guadagno, Thomas M.

“…Survivin is a member of the inhibitor of apoptosis (IAP) protein family that serves critical roles in mitosis and cytokinesis. Many studies have suggested…”
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Requirement for MAPK Activation for Normal Mitotic Progression in Xenopus Egg Extracts by Guadagno, Thomas M., Ferrell, James E.

“…The p42 mitogen-activated protein kinase (MAPK) is required for progression through meiotic M phase in Xenopus oocytes. This report examines whether it also…”
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Induction of a G2-phase arrest in Xenopus egg extracts by activation of p42 mitogen-activated protein kinase by Walter, S A, Guadagno, T M, Ferrell, Jr, J E

“…Previous work has established that activation of Mos, Mek, and p42 mitogen-activated protein (MAP) kinase can trigger release from G2-phase arrest in Xenopus…”
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Too much ERK, not enough erythrocytes by Guadagno, Thomas M.

“…Comment on Zhang and Lodish, page Expression of oncogenic H-ras in primary erythroid progenitors activates several signaling pathways of which the MEK/ERK…”
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G1/S Control of Anchorage-Independent Growth in the Fibroblast Cell Cycle by Guadagno, Thomas M., Assoian, Richard K.

“…We have developed methodology to identify the block to anchorage-independent growth and position it within the fibroblast cell cycle. Results with NRK…”
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Induction of a G 2 -Phase Arrest in Xenopus Egg Extracts by Activation of p42 Mitogen-activated Protein Kinase by Walter, Sarah A., Guadagno, Thomas M., Ferrell, James E.

“…Previous work has established that activation of Mos, Mek, and p42 mitogen-activated protein (MAP) kinase can trigger release from G 2 -phase arrest in Xenopus…”
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A Cell Cycle and Mutational Analysis of Anchorage-Independent Growth: Cell Adhesion and TGF-β1 Control G1/S Transit Specifically by Han, Edward Kyu-Ho, Guadagno, Thomas M., Dalton, Stephen L., Assoian, Richard K.

“…We have examined cell cycle control of anchorage-independent growth in nontransformed fibroblasts. In previous studies using G0-synchronized NRK and NIH-3T3…”
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A cell cycle and mutational analysis of anchorage-independent growth: Cell adhesion and TGF(Beta)1 control G1/S transit specifically by Han, Edward Kyu-Ho, Guadagno, Thomas M, Dalton, Stephen L, Assoian, Richard K

“…Cell-cycle control of anchorage-independent growth in nontransformed fibroblasts was examined. Results show that S-, G2- and M-phase progression proceed in the…”
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