Search Results - "Gu-Jiun Lin"
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Triptolide suppresses oral cancer cell PD-L1 expression in the interferon-γ-modulated microenvironment in vitro, in vivo, and in clinical patients
Published in Biomedicine & pharmacotherapy (01-01-2021)“…[Display omitted] •PD-L1 is overexpressed in oral cancer patients.•TPL inhibits tumor growth in oral cancer models by downregulating PD-L1.•IFN-γ increases…”
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Immunopathogenic Mechanisms and Novel Immune-Modulated Therapies in Rheumatoid Arthritis
Published in International journal of molecular sciences (16-03-2019)“…Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown etiology. It is characterized by the presence of rheumatoid factor and…”
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Microglial Nox2 Plays a Key Role in the Pathogenesis of Experimental Autoimmune Encephalomyelitis
Published in Frontiers in immunology (02-04-2021)“…While oxidative stress has been linked to multiple sclerosis (MS), the role of superoxide-producing phagocyte NADPH oxidase (Nox2) in central nervous system…”
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4
Interleukin 26 Induces Macrophage IL-9 Expression in Rheumatoid Arthritis
Published in International journal of molecular sciences (01-04-2023)“…Rheumatoid arthritis (RA) is an autoimmune disease with chronic inflammation, bone erosion, and joint deformation. Synovial tissue in RA patients is full of…”
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5
Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases
Published in International Journal of Molecular Sciences (31-05-2013)“…Melatonin is the major secretory product of the pineal gland during the night and has multiple activities including the regulation of circadian and seasonal…”
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RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury
Published in Cell death & disease (21-06-2023)“…Acute lung injury (ALI) is characterised by severe pulmonary inflammation, alveolar-capillary barrier disruption, and pulmonary oedema. Therefore, establishing…”
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7
Alpha-lipoic acid ameliorates influenza A virus caused acute pneumonia though enhancement of anti-viral T cell immunity and suppression of macrophage activation by inhibiting ERK1/2 signaling pathway
Published in Journal of functional foods (01-05-2024)“…[Display omitted] •ALA exhibits prophylactic potential in influenza A virus induced acute pneumonia.•ALA acts with differing immunomodulatory effects on…”
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Melatonin possesses an anti-influenza potential through its immune modulatory effect
Published in Journal of functional foods (01-07-2019)“…[Display omitted] •Melatonin exhibits a therapeutic potential in influenza A H1N1 virus infection.•Melatonin elicits anti-inflammatory and immune modulatory…”
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Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model
Published in PloS one (17-07-2020)“…Dysregulation of histone demethylase Jumonji-C domain-containing protein 5 (JMJD5) has been identified as a great effect on tumorigenesis. Silibinin is a…”
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Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-κB Pathway
Published in Cells (Basel, Switzerland) (10-04-2020)“…Interleukin 26 (IL-26) is a new member of the IL-10 family that is highly expressed in rheumatoid arthritis (RA). However, the functions of IL-26 produced by…”
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Alpha-Lipoic Acid Inhibits Spontaneous Diabetes and Autoimmune Recurrence in Non-Obese Diabetic Mice by Enhancing Differentiation of Regulatory T Cells and Showed Potential for Use in Cell Therapies for the Treatment of Type 1 Diabetes
Published in International journal of molecular sciences (21-01-2022)“…Type 1 diabetes (T1D) is caused by the destruction of β cells in pancreatic islets by autoimmune T cells. Islet transplantation has been established as an…”
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12
The influence of digitalized examination of the histology laboratory course on medical and dental students: A retrospective study
Published in Journal of Medical Sciences (01-09-2023)“…Background: Histology laboratory courses comprise the study of cell structures, tissues, and body organs, which are mainly examined using a microscope. Two…”
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Anti‐oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient‐derived tumor xenograft model
Published in Head & neck (01-05-2019)“…Background Aberrant expression of decoy receptor 3 (DcR3) is considered to be a diagnostic and therapeutic target for human cancers. The aim of this study was…”
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Valproic Acid Suppresses Autoimmune Recurrence and Allograft Rejection in Islet Transplantation through Induction of the Differentiation of Regulatory T Cells and Can Be Used in Cell Therapy for Type 1 Diabetes
Published in Pharmaceuticals (Basel, Switzerland) (17-05-2021)“…Type 1 diabetes mellitus (T1D) results from the destruction of insulin-producing β cells in the islet of the pancreas by lymphocytes. Non-obese diabetic (NOD)…”
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15
Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1α/IL-1 Receptor Antagonist Pathway
Published in Mediators of inflammation (2020)“…Purpose. Interleukin-1α (IL-1α) is a potent cytokine that plays a role in inflammatory arthritis and bone loss. Decoy receptor 3 (DCR3) is an immune modulator…”
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Melatonin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental murine membranous nephropathy
Published in Journal of pineal research (01-05-2012)“…: Idiopathic membranous nephropathy (MN), an autoimmune‐mediated glomerulonephritis, is one of the most common causes of nephrotic syndrome in adults…”
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Undifferentiated Wharton's Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T-Cell-Mediated Autoimmunity in Nonobese Diabetic Mice
Published in Cell transplantation (01-08-2015)“…Type 1 diabetes mellitus is caused by T-cell-mediated autoimmune destruction of pancreatic β-cells. Systemic administration of mesenchymal stem cells (MSCs)…”
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Allyl Isothiocyanate Suppresses the Proliferation in Oral Squamous Cell Carcinoma via Mediating the KDM8/CCNA1 Axis
Published in Biomedicines (29-09-2023)“…The dysregulated expression of cyclin genes can lead to the uncontrolled proliferation of cancer cells. Histone demethylase Jumonji-C domain-containing protein…”
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A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo
Published in PloS one (15-08-2014)“…Oral squamous cell carcinoma (OSCC) is a prevalent cancer, especially in developing countries. Anthracyclines and their anthraquinone derivatives, such as…”
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Melatonin prolongs islet graft survival in diabetic NOD mice
Published in Journal of pineal research (01-10-2009)“…: Islet transplantation has been established as a potential therapy for type 1 diabetes. However, inflammation, allorejection, and on‐going autoimmune damage…”
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