Search Results - "Gu-Jiun Lin"

Triptolide suppresses oral cancer cell PD-L1 expression in the interferon-γ-modulated microenvironment in vitro, in vivo, and in clinical patients by Kuo, Chin-Shan, Yang, Cheng-Yu, Lin, Chih-Kung, Lin, Gu-Jiun, Sytwu, Huey-Kang, Chen, Yuan-Wu

“…[Display omitted] •PD-L1 is overexpressed in oral cancer patients.•TPL inhibits tumor growth in oral cancer models by downregulating PD-L1.•IFN-γ increases…”
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Immunopathogenic Mechanisms and Novel Immune-Modulated Therapies in Rheumatoid Arthritis by Chen, Shyi-Jou, Lin, Gu-Jiun, Chen, Jing-Wun, Wang, Kai-Chen, Tien, Chiung-Hsi, Hu, Chih-Fen, Chang, Chia-Ning, Hsu, Wan-Fu, Fan, Hueng-Chuen, Sytwu, Huey-Kang

“…Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown etiology. It is characterized by the presence of rheumatoid factor and…”
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Microglial Nox2 Plays a Key Role in the Pathogenesis of Experimental Autoimmune Encephalomyelitis by Hu, Chih-Fen, Wu, San-Pin, Lin, Gu-Jiun, Shieh, Chi-Chang, Hsu, Chih-Sin, Chen, Jing-Wun, Chen, Shih-Heng, Hong, Jau-Shyong, Chen, Shyi-Jou

“…While oxidative stress has been linked to multiple sclerosis (MS), the role of superoxide-producing phagocyte NADPH oxidase (Nox2) in central nervous system…”
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Interleukin 26 Induces Macrophage IL-9 Expression in Rheumatoid Arthritis by Wang, Yi-Hsun, Peng, Yi-Jen, Liu, Feng-Cheng, Lin, Gu-Jiun, Huang, Shing-Hwa, Sytwu, Huey-Kang, Cheng, Chia-Pi

“…Rheumatoid arthritis (RA) is an autoimmune disease with chronic inflammation, bone erosion, and joint deformation. Synovial tissue in RA patients is full of…”
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Modulation by melatonin of the pathogenesis of inflammatory autoimmune diseases by Lin, Gu-Jiun, Huang, Shing-Hwa, Chen, Shyi-Jou, Wang, Chih-Hung, Chang, Deh-Ming, Sytwu, Huey-Kang

“…Melatonin is the major secretory product of the pineal gland during the night and has multiple activities including the regulation of circadian and seasonal…”
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RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury by Liu, Pei-Yao, Chen, Chih-Yuan, Lin, Yu-Lung, Lin, Chien-Ming, Tsai, Wen-Chiuan, Tsai, Yu-Ling, Lin, Gu-Jiun, Chen, Yu-Guang, Wang, Shih-Yun, Sun, Rui-Nong, Huang, Yu-Chuan, Chang, Hung, Chen, Ying-Chuan

“…Acute lung injury (ALI) is characterised by severe pulmonary inflammation, alveolar-capillary barrier disruption, and pulmonary oedema. Therefore, establishing…”
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Alpha-lipoic acid ameliorates influenza A virus caused acute pneumonia though enhancement of anti-viral T cell immunity and suppression of macrophage activation by inhibiting ERK1/2 signaling pathway by Tsai, Meng-Wei, Huang, Shing-Hwa, Chen, Shyi-Jou, Ling, Yu-Chieh, Huang, Jing-Ya, Jeng, Po-Hsuan, Chen, Mei-Fei, Sytwu, Huey-Kang, Lin, Gu-Jiun

“…[Display omitted] •ALA exhibits prophylactic potential in influenza A virus induced acute pneumonia.•ALA acts with differing immunomodulatory effects on…”
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Melatonin possesses an anti-influenza potential through its immune modulatory effect by Huang, Shing-Hwa, Liao, Ching-Len, Chen, Shyi-Jou, Shi, Li-Ge, Lin, Li, Chen, Yuan-Wu, Cheng, Chia-Pi, Sytwu, Huey-Kang, Shang, Shih-Ta, Lin, Gu-Jiun

“…[Display omitted] •Melatonin exhibits a therapeutic potential in influenza A H1N1 virus infection.•Melatonin elicits anti-inflammatory and immune modulatory…”
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Downregulation of Jumonji-C domain-containing protein 5 inhibits proliferation by silibinin in the oral cancer PDTX model by Yang, Cheng-Yu, Tsao, Chang-Huei, Hsieh, Cheng-Chih, Lin, Chih-Kung, Lin, Chun-Shu, Li, Yu-Hsuan, Chang, Wei-Chin, Cheng, Jen-Chen, Lin, Gu-Jiun, Sytwu, Huey-Kang, Wang, Yin-Lai, Chen, Yuan-Wu

“…Dysregulation of histone demethylase Jumonji-C domain-containing protein 5 (JMJD5) has been identified as a great effect on tumorigenesis. Silibinin is a…”
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Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-κB Pathway by Lin, Yi-Hsuan, Wang, Yi-Hsun, Peng, Yi-Jen, Liu, Feng-Cheng, Lin, Gu-Jiun, Huang, Shing-Hwa, Sytwu, Huey-Kang, Cheng, Chia-Pi

“…Interleukin 26 (IL-26) is a new member of the IL-10 family that is highly expressed in rheumatoid arthritis (RA). However, the functions of IL-26 produced by…”
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Alpha-Lipoic Acid Inhibits Spontaneous Diabetes and Autoimmune Recurrence in Non-Obese Diabetic Mice by Enhancing Differentiation of Regulatory T Cells and Showed Potential for Use in Cell Therapies for the Treatment of Type 1 Diabetes by Huang, Shing-Hwa, Kuo, Shun-Li, Chen, Shyi-Jou, Lin, Jeng-Rong, Chen, Yuan-Wu, Hong, Zhi-Jie, Sytwu, Huey-Kang, Lin, Gu-Jiun

“…Type 1 diabetes (T1D) is caused by the destruction of β cells in pancreatic islets by autoimmune T cells. Islet transplantation has been established as an…”
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The influence of digitalized examination of the histology laboratory course on medical and dental students: A retrospective study by Ming-Hsien Chiang, Hsin-Chieh Lan, Chia-Pi Cheng, Jang-Yi Chen, Fon-Yi Yin, Gu-Jiun Lin

“…Background: Histology laboratory courses comprise the study of cell structures, tissues, and body organs, which are mainly examined using a microscope. Two…”
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Anti‐oral cancer effects of triptolide by downregulation of DcR3 in vitro, in vivo, and in preclinical patient‐derived tumor xenograft model by Yang, Cheng‐Yu, Lin, Chih‐Kung, Hsieh, Cheng‐Chih, Tsao, Chang‐Huei, Lin, Chun‐Shu, Peng, Bo, Chen, Yen‐Tzu, Ting, Chun‐Chieh, Chang, Wei‐Chin, Lin, Gu‐Jiun, Sytwu, Huey‐Kang, Chen, Yuan‐Wu

“…Background Aberrant expression of decoy receptor 3 (DcR3) is considered to be a diagnostic and therapeutic target for human cancers. The aim of this study was…”
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Valproic Acid Suppresses Autoimmune Recurrence and Allograft Rejection in Islet Transplantation through Induction of the Differentiation of Regulatory T Cells and Can Be Used in Cell Therapy for Type 1 Diabetes by Lin, Jeng-Rong, Huang, Shing-Hwa, Wu, Chih-Hsiung, Chen, Yuan-Wu, Hong, Zhi-Jie, Cheng, Chia-Pi, Sytwu, Huey-Kang, Lin, Gu-Jiun

“…Type 1 diabetes mellitus (T1D) results from the destruction of insulin-producing β cells in the islet of the pancreas by lymphocytes. Non-obese diabetic (NOD)…”
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Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1α/IL-1 Receptor Antagonist Pathway by Cheng, Chia-Pi, Chen, Shyi-Jou, Huang, Shing-Hwa, Lin, Gu-Jiun, Lin, Yi-Hsuan, Peng, Ching-Tsung, Peng, Yi-Jen, Sytwu, Huey-Kang

“…Purpose. Interleukin-1α (IL-1α) is a potent cytokine that plays a role in inflammatory arthritis and bone loss. Decoy receptor 3 (DCR3) is an immune modulator…”
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Melatonin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental murine membranous nephropathy by Wu, Chia-Chao, Lu, Kuo-Cheng, Lin, Gu-Jiun, Hsieh, Hsin-Yi, Chu, Pauling, Lin, Shih-Hua, Sytwu, Huey-Kang

“…:  Idiopathic membranous nephropathy (MN), an autoimmune‐mediated glomerulonephritis, is one of the most common causes of nephrotic syndrome in adults…”
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Undifferentiated Wharton's Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T-Cell-Mediated Autoimmunity in Nonobese Diabetic Mice by Tsai, Pei-Jiun, Wang, Hwai-Shi, Lin, Gu-Jiun, Chou, Shu-Cheng, Chu, Tzu-Hui, Chuan, Wen-Ting, Lu, Ying-Jui, Weng, Zen-Chung, Su, Cheng-Hsi, Hsieh, Po-Shiuan, Sytwu, Huey-Kang, Lin, Chi-Hung, Chen, Tien-Hua, Shyu, Jia-Fwu

“…Type 1 diabetes mellitus is caused by T-cell-mediated autoimmune destruction of pancreatic β-cells. Systemic administration of mesenchymal stem cells (MSCs)…”
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Allyl Isothiocyanate Suppresses the Proliferation in Oral Squamous Cell Carcinoma via Mediating the KDM8/CCNA1 Axis by Hsieh, Cheng-Chih, Yang, Cheng-Yu, Peng, Bo, Ho, Sien-Lin, Tsao, Chang-Huei, Lin, Chih-Kung, Lin, Chun-Shu, Lin, Gu-Jiun, Lin, Heng-Yi, Huang, Hung-Chi, Chang, Szu-Chien, Sytwu, Huey-Kang, Chia, Wei-Tso, Chen, Yuan-Wu

“…The dysregulated expression of cyclin genes can lead to the uncontrolled proliferation of cancer cells. Histone demethylase Jumonji-C domain-containing protein…”
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A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo by Chen, Yuan-Wu, Huang, Hsu-Shan, Shieh, Yi-Shing, Ma, Kuo-Hsing, Huang, Shing-Hwa, Hueng, Dueng-Yuan, Sytwu, Huey-Kang, Lin, Gu-Jiun

“…Oral squamous cell carcinoma (OSCC) is a prevalent cancer, especially in developing countries. Anthracyclines and their anthraquinone derivatives, such as…”
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Melatonin prolongs islet graft survival in diabetic NOD mice by Lin, Gu-Jiun, Huang, Shing-Hwa, Chen, Yuan-Wu, Hueng, Dueng-Yuan, Chien, Ming-Wei, Chia, Wei-Tso, Chang, Deh-Ming, Sytwu, Huey-Kang

“…:  Islet transplantation has been established as a potential therapy for type 1 diabetes. However, inflammation, allorejection, and on‐going autoimmune damage…”
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