Search Results - "Guðmundsson, Júlíus"
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Profile of common prostate cancer risk variants in an unscreened Romanian population
Published in Journal of cellular and molecular medicine (01-03-2018)“…To find sequence variants affecting prostate cancer (PCA) susceptibility in an unscreened Romanian population we use a genome‐wide association study (GWAS)…”
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2
A genome-wide association study yields five novel thyroid cancer risk loci
Published in Nature communications (14-02-2017)“…The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid…”
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3
Loss-of-function variants in ATM confer risk of gastric cancer
Published in Nature genetics (01-08-2015)“…Hannes Helgason, Kari Stefansson and colleagues report an association study of gastric cancer susceptibility based on whole-genome sequencing in the Icelandic…”
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4
Assessing thyroid cancer risk using polygenic risk scores
Published in Proceedings of the National Academy of Sciences - PNAS (17-03-2020)“…Genome-wide association studies (GWASs) have identified at least 10 single-nucleotide polymorphisms (SNPs) associated with papillary thyroid cancer (PTC) risk…”
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5
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA
Published in Nature communications (08-11-2018)“…Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we…”
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Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma
Published in Human molecular genetics (01-06-2014)“…To search for new sequence variants that confer risk of cutaneous basal cell carcinoma (BCC), we conducted a genome-wide association study of 38.5 million…”
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Association of Folate-Pathway Gene Polymorphisms with the Risk of Prostate Cancer: a Population-Based Nested Case-Control Study, Systematic Review, and Meta-analysis
Published in Cancer epidemiology, biomarkers & prevention (01-09-2009)“…Folate-pathway gene polymorphisms have been implicated in several cancers and investigated inconclusively in relation to prostate cancer. We conducted a…”
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A method for detecting long non-coding RNAs with tiled RNA expression microarrays
Published in PloS one (17-06-2014)“…Long non-coding ribonucleic acids (lncRNAs) have been proposed as biomarkers in prostate cancer. This paper proposes a selection method which uses data from…”
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Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank
Published in Communications biology (17-03-2020)“…Pelvic organ prolapse (POP) is a downward descent of one or more of the pelvic organs, resulting in a protrusion of the vaginal wall and/or uterus. We…”
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The BARD1 Cys557Ser variant and breast cancer risk in Iceland
Published in PLoS medicine (01-07-2006)“…Most, if not all, of the cellular functions of the BRCA1 protein are mediated through heterodimeric complexes composed of BRCA1 and a related protein, BARD1…”
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Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
Published in Blood (10-08-2017)“…Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is derived from a single dominant hematopoietic stem cell lineage. Somatic…”
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GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer
Published in Nature communications (07-08-2020)“…Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a…”
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13
Insights into imprinting from parent-of-origin phased methylomes and transcriptomes
Published in Nature genetics (01-11-2018)“…Imprinting is the preferential expression of one parental allele over the other. It is controlled primarily through differential methylation of cytosine at CpG…”
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14
Mutations in BRIP1 confer high risk of ovarian cancer
Published in Nature genetics (01-11-2011)“…Ovarian cancer causes more deaths than any other gynecologic malignancy in developed countries. Sixteen million sequence variants, identified through…”
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15
A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Published in Nature (03-04-2008)“…Smoking is a leading cause of preventable death, causing about 5 million premature deaths worldwide each year. Evidence for genetic influence on smoking…”
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Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits
Published in Nature communications (07-09-2018)“…Uterine leiomyomas are common benign tumors of the myometrium. We performed a meta-analysis of two genome-wide association studies of leiomyoma in European…”
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17
Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis
Published in Nature genetics (01-12-2023)“…Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is derived from a single hematopoietic stem cell lineage. Using…”
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Discovery of common variants associated with low TSH levels and thyroid cancer risk
Published in Nature genetics (01-03-2012)“…Julius Gudmundsson and colleagues report a genome-wide association study for circulating levels of thyroid-stimulating hormone in 27,758 individuals not known…”
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Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations
Published in Cancer research (Chicago, Ill.) (01-09-2016)“…Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct…”
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Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Published in Nature genetics (01-05-2007)“…Prostate cancer is the most prevalent noncutaneous cancer in males in developed regions, with African American men having among the highest worldwide incidence…”
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