Search Results - "Guégan, P."

Circulating L-arginine predicts the survival of cancer patients treated with immune checkpoint inhibitors by Peyraud, F., Guégan, J.-P., Bodet, D., Nafia, I., Fontan, L., Auzanneau, C., Cousin, S., Roubaud, G., Cabart, M., Chomy, F., Le Loarer, F., Chaput, N., Danlos, F.-X., Planchard, D., Even, C., Khettab, M., Tselikas, L., Besse, B., Barlesi, F., Soria, J.-C., Marabelle, A., Bessede, A., Italiano, A.

“…The discovery of immune checkpoint inhibitors (ICIs) has revolutionized the systemic approach to cancer treatment. Most patients receiving ICIs, however, do…”
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Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker of immune-checkpoint blockade resistance by Loriot, Y., Marabelle, A., Guégan, J.P., Danlos, F.X., Besse, B., Chaput, N., Massard, C., Planchard, D., Robert, C., Even, C., Khettab, M., Tselikas, L., Friboulet, L., André, F., Nafia, I., Le Loarer, F., Soria, J.C., Bessede, A., Italiano, A.

“…Immune checkpoint blockers (ICBs) are now widely used in oncology. Most patients, however, do not derive benefit from these agents. Therefore, there is a…”
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Impact of acetaminophen on the efficacy of immunotherapy in cancer patients by Bessede, A., Marabelle, A., Guégan, J.P., Danlos, F.X., Cousin, S., Peyraud, F., Chaput, N., Spalato, M., Roubaud, G., Cabart, M., Khettab, M., Chaibi, A., Rey, C., Nafia, I., Mahon, F.X., Soria, J.C., Italiano, A.

“…Acetaminophen (APAP) use has been associated with blunted vaccine immune responses. This study aimed to assess APAP impact on immunotherapy efficacy in…”
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ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential by Frémin, C, Guégan, J-P, Plutoni, C, Mahaffey, J, Philips, M R, Emery, G, Meloche, S

“…The Ras-related (R-Ras) isoforms TC21, R-Ras and M-Ras are members of the Ras superfamily of small GTPases. R-Ras family proteins are frequently overexpressed…”
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High Conversion Synthesis of Pyrene End Functionalized Polyrotaxane Based on Poly(ethylene oxide) and α-Cyclodextrins by Jarroux, N, Guégan, P, Cheradame, H, Auvray, L

“…We describe the quantitative synthesis of new pyrene labeled cyclodextrin-based polyrotaxane starting from pseudopolyrotaxane of α,ω-dimethacrylate…”
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FIB patterning of dielectric, metallized and graphene membranes: A comparative study by Hemamouche, A., Morin, A., Bourhis, E., Toury, B., Tarnaud, E., Mathé, J., Guégan, P., Madouri, A., Lafosse, X., Ulysse, C., Guilet, S., Patriarche, G., Auvray, L., Montel, F., Wilmart, Q., Plaçais, B., Yates, J., Gierak, J.

“…[Display omitted] •FIB allows production of commercially viable nanopore-based devices.•FIB technique applicable to free-standing and atomically-thin…”
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Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort by Italiano, A., Bessede, A., Pulido, M., Bompas, E., Piperno-Neumann, S., Chevreau, C., Penel, N., Bertucci, F., Toulmonde, M., Bellera, C., Guegan, J. P., Rey, C., Sautès-Fridman, C., Bougoüin, A., Cantarel, C., Kind, M., Spalato, M., Dadone-Montaudie, B., Le Loarer, F., Blay, J. Y., Fridman, W. H.

“…Immune checkpoint inhibitors (ICIs) show limited clinical activity in patients with advanced soft-tissue sarcomas (STSs). Retrospective analysis suggests that…”
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Variation of the mesh size of PEO-based networks filled with TFSILi: from an Arrhenius to WLF type conductivity behavior by Carvalho, L.M, Guégan, P, Cheradame, H, Gomes, A.S

“…The properties of ionically conducting membranes based on polyethylene oxide (PEO) networks crosslinked with urethane functions, containing lithium…”
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Dynamic tensile test of single PET textile cables by Hiermaier, S., Guégan, P., Othman, R., Pasco, F., Bruant, R.

“…The tyres conception involves for certain applications, the use of textile cables as reinforcement. During its use, the tyre undergoes temperatures variations…”
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Temperature sensitive supramolecular self assembly of per-6-PEO-β-cyclodextrin and α,ω-di-(adamantylethyl)poly(N-isopropylacrylamide) in water by Bennevault, V, Huin, C, Guégan, P, Evgeniya, K, Qiu, X-P, Winnik, F M

“…The host/guest interactions in water of a star polymer consisting of a β-cyclodextrin (β-CD) core bearing six poly(ethylene oxide) arms linked to the C6…”
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Histidinylated linear PEIs as new DNA carriers for in vitro and in vivo gene transfer with low toxicity by Guégan, P, Bertrand, E, Le Gall, T, Pichon, C, Montier, T, Lehn, P, Cheradame, H, Midoux, P

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Nuclear delivery of DNA/histidine-polymer complexes: confocal microscopy real time investigation of the nuclear import of a plasmid DNA containing an optimized DNA κB sequence by Breuzard, G, Gonçalves, C, Thibault, T, Cheradame, H, Guégan, P, Hartmann, B, Pichon, C, Midoux, P

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Stabilization of α-chymotrypsin by ionic liquids in transesterification reactions by Lozano, Pedro, de Diego, Teresa, Guegan, Jean-Paul, Vaultier, Michel, Iborra, José L.

“…Five different ionic liquids, based on dialkylimidazolium and quaternary ammonium cations associated with perfluorinated and bis (trifluoromethyl) sulfonyl…”
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A Drop-Bar Setup for the Compressive Testing of Rubber-Like Materials in the Intermediate Strain Rate Range by Petiteau, J.-C., Othman, R., Guégan, P., Le Sourne, H., Verron, E.

“…ABSTRACT Only few works have been focused on soft materials at medium strain rates. In the present paper, we propose a new experimental setup to investigate…”
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Anionic Synthesis, Modification, and Characterization of ABC Triblock Copolymers by Guégan, P, Cernohous, J. J, Khandpur, A. K, Hoye, T. R, Macosko, C. W

“…ABC triblock copolymers of poly(styrene)-b-poly(tert-butyl methacrylate)-b-poly(methyl methacrylate) (PS-PtBMA-PMMA) were anionically synthesized by sequential…”
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Homogeneous reactive coupling of terminally functional polymers by Orr, C.A., Cernohous, J.J., Guegan, P., Hirao, A., Jeon, H.K., Macosko, C.W.

“…The rates of nine melt coupling reactions were measured by reacting terminally functional polymer chains. The functional groups are carboxylic acid, oxazoline,…”
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Kinetics of Chain Coupling at Melt Interfaces by Guegan, P, Macosko, C. W, Ishizone, T, Hirao, A, Nakahama, S

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Tuning Macromolecular Structures of Synthetic Vectors for Gene Therapy by Cheradame, H., Sassatelli, M., Pomel, C., Sanh, A., Gau-Racine, J., Bacri, L., Auvray, L., Guégan, P.

“…The synthesis of triblocks poly(2‐methyl‐2‐oxazoline‐b‐tetrahydrofurane‐b‐2‐methyl‐2‐oxazoline) has been developed. It was shown that the technique of…”
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Synthesis of fluorene copolymer with persilylated gamma-cyclodextrin in the main chain by Farcas, A, Jarroux, N, Guegan, P, Harabagiu, V, Melnig, V

“…Polyfluorene copolymers with and without persilylated gamma-cyclodextrin (gamma-CD) threaded onto the main chain were synthesized by using the well-known…”
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Improvement of Synthetic Vectors for Gene Therapy Using Ring-Opening Cationic Polymerization by Cheradame, H., Brissault, B., Guis, C., Guégan, P., Pomel, C., Kichler, A., Gau, J., Auvray, L.

“…For efficirent gene transfer, DNA has to be associated with a carrier which can be either of biological (i.e. recombinant viruses) or synthetic origin. In the…”
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