Search Results - "Gu, Yongli"

Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain by Bolduc, David M., Montagna, Daniel R., Gu, Yongli, Selkoe, Dennis J., Wolfe, Michael S.

“…γ-Secretase is an intramembrane-cleaving protease that processes many type-I integral membrane proteins within the lipid bilayer, an event preceded by shedding…”
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Modifications of H3 and H4 during Chromatin Replication, Nucleosome Assembly, and Histone Exchange by Benson, Laura J., Gu, Yongli, Yakovleva, Tatyana, Tong, Kevin, Barrows, Courtney, Strack, Christine L., Cook, Richard G., Mizzen, Craig A., Annunziato, Anthony T.

“…Histone posttranslational modifications that accompany DNA replication, nucleosome assembly, and H2A/H2B exchange were examined in human tissue culture cells…”
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激光驱动飞秒电子束消色差传输束线设计 by 朱军高, 卢海洋, 赵媛, 赖美福, 古永力, 徐世祥, 温猛, 周沧涛

“…TL501%O434.12;…”
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Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein by Yang, Ting, Arslanova, Dilyara, Gu, Yongli, Augelli-Szafran, Corinne, Xia, Weiming

“…Deposition of amyloid-β protein (Aβ) is a major pathological hallmark of Alzheimer's disease (AD). Aβ is generated from γ-secretase cleavage of amyloid…”
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Visualization of module alignment discovery by Chaojuan, Xiang, Jiang, Xie, Yongli, Gu, Junfu, Xu, Kai, Lu

“…Network alignment is an efficient approach for understanding similarities and dissimilarities of protein interaction networks (PINs) from different species…”
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Properties of the Type B Histone Acetyltransferase Hat1 by Benson, Laura J., Phillips, Jane A., Gu, Yongli, Parthun, Mark R., Hoffman, Charles S., Annunziato, Anthony T.

“…The Hat1 histone acetyltransferase catalyzes the acetylation of H4 at lysines 5 and 12, the same sites that are acetylated in newly synthesized histone H4. By…”
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The association between blood eosinophils and clinical outcome of acute exacerbations of chronic obstructive pulmonary disease: A systematic review and meta-analysis by Liu, Hai, Xie, Yongpeng, Huang, Yuanyuan, Luo, Kangle, Gu, Yongli, Zhang, Huan, Xu, Yi, Chen, Xuefeng

“…Studies have shown an association between eosinophilia and clinical outcomes in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). However,…”
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In Vitro Drug-Drug Interaction Evaluation of GalNAc Conjugated siRNAs Against CYP450 Enzymes and Transporters by Ramsden, Diane, Wu, Jing-Tao, Zerler, Brad, Iqbal, Sajida, Jiang, Jim, Clausen, Valerie, Aluri, Krishna, Gu, Yongli, Dennin, Sean, Kim, Joohwan, Chong, Saeho

“…Small interfering RNAs (siRNAs) represent a new class of medicines that are smaller (∼16,000 Da) than biologic therapeutics (>150,000 Da) but much larger than…”
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The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N -Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human by McDougall, Robin, Ramsden, Diane, Agarwal, Sagar, Agarwal, Saket, Aluri, Krishna, Arciprete, Michael, Brown, Christopher, Castellanos-Rizaldos, Elena, Charisse, Klaus, Chong, Saeho, Cichocki, Joseph, Fitzgerald, Kevin, Goel, Varun, Gu, Yongli, Guenther, Dale, Habtemariam, Bahru, Jadhav, Vasant, Janas, Maja, Jayaraman, Muthusamy, Kurz, Jeffrey, Li, Jing, Liu, Ju, Liu, Xiumin, Liou, Steven, Maclauchlin, Chris, Maier, Martin, Manoharan, Muthiah, Nair, Jayaprakash K, Robbie, Gabriel, Schmidt, Karyn, Smith, Peter, Theile, Christopher, Vaishnaw, Akshay, Waldron, Scott, Xu, Yuanxin, Zhang, Xuemei, Zlatev, Ivan, Wu, Jing-Tao

“…Conjugation of oligonucleotide therapeutics, including small interfering RNAs (siRNAs) or antisense oligonucleotides, to -acetylgalactosamine (GalNAc) ligands…”
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Impact of Serum Proteins on the Uptake and RNAi Activity of GalNAc-Conjugated siRNAs by Agarwal, Saket, Allard, Ruth, Darcy, Justin, Chigas, Samantha, Gu, Yongli, Nguyen, Tuyen, Bond, Sarah, Chong, Saeho, Wu, Jing-Tao, Janas, Maja M

“…Serum protein interactions are evaluated during the drug development process since they determine the free drug concentration in blood and thereby can…”
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Nicastrin functions to sterically hinder [gamma]-secretase-substrate interactions driven by substrate transmembrane domain by Bolduc, David M, Montagna, Daniel R, Gu, Yongli, Selkoe, Dennis J, Wolfe, Michael S

“…-Secretase is an intramembrane-cleaving protease that processes many type-I integral membrane proteins within the lipid bilayer, an event preceded by…”
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Evaluation of electrophoretic mobility shift assay as a method to determine plasma protein binding of siRNA by Rocca, Carrie, Dennin, Sean, Gu, Yongli, Kim, Joohwan, Chigas, Samantha, Najarian, Diana, Chong, Saeho, Gutierrez, Shannon, Butler, James, Charisse, Klaus, Robbie, Gabriel, Xu, Yuanxin, Brown, Kirk

“…The electrophoretic mobility shift assay (EMSA) was evaluated as an alternative to ultrafiltration (UF) to assess plasma protein binding (PPB) of small…”
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Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols by Wei, Han-Xun, Lu, Dai, Sun, Vivien, Zhang, Jing, Gu, Yongli, Osenkowski, Pamela, Ye, Wenjuan, Selkoe, Dennis J., Wolfe, Michael S., Augelli-Szafran, Corinne E.

“…[Display omitted] One therapeutic approach for Alzheimer’s disease is to inhibit the cleavage of the amyloid precursor protein (APP) by γ-secretase. At the…”
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Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones by Zhang, Jing, Lu, Dai, Wei, Han-Xun, Gu, Yongli, Selkoe, Dennis J., Wolfe, Michael S., Augelli-Szafran, Corinne E.

“…[Display omitted] In search for novel lead compounds as γ-secretase inhibitors, analogs of aminopyrido[2,3-d]pyrimidin-7-ones (I) were synthesized and…”
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Analysis of Aging Mechanism of SBS Polymer Modified Asphalt based on Fourier Transform Infrared Spectrum by Zhao, Yongli, Gu, Fan, Xu, Jing, Jin, Jing

“…The aging mechanism of SBS modified asphalt during its aging process was studied.The characterizations of base asphalt,SBS polymer and its modified asphalt…”
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Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs by Lu, Dai, Wei, Han-Xun, Zhang, Jing, Gu, Yongli, Osenkowski, Pamela, Ye, Wenjuan, Selkoe, Dennis J., Wolfe, Michael S., Augelli-Szafran, Corinne E.

“…[Display omitted] γ-Secretase is one of two proteases directly involved in the production of the amyloid β-peptide (Aβ), which is pathogenic in Alzheimer’s…”
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Properties of the Type B Histone Acetyltransferase Hat1: H4 TAIL INTERACTION, SITE PREFERENCE, AND INVOLVEMENT IN DNA REPAIR by Benson, Laura J, Phillips, Jane A, Gu, Yongli, Parthun, Mark R, Hoffman, Charles S, Annunziato, Anthony T

“…The Hat1 histone acetyltransferase catalyzes the acetylation of H4 at lysines 5 and 12, the same sites that are acetylated in newly synthesized histone H4. By…”
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P4–294: Gamma‐secretase as a target for Alzheimer's disease therapy: Small‐molecule development by Augelli‐Szafran, Corinne, Brogan, Katherine, Cai, Cuiman, Chen, Jian, Gu, Yongli, Selkoe, Dennis, Wei, Han‐Xun, Wolfe, Michael, Zhang, Jing

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Gamma-secretase as a target for Alzheimer's disease therapy: Small-molecule development by Augelli-Szafran, Corinne, Brogan, Katherine, Cai, Cuiman, Chen, Jian, Gu, Yongli, Selkoe, Dennis, Wei, Han-Xun, Wolfe, Michael, Zhang, Jing

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Molecular identification of a bevy of serine proteinases in Manduca sexta hemolymph by Jiang, Haobo, Wang, Yang, Gu, Yongli, Guo, Xiaoping, Zou, Zhen, Scholz, Frank, Trenczek, Tina E., Kanost, Michael R.

“…Extracellular serine proteinase pathways control immune and homeostatic processes in insects. Our current knowledge of their components is limited—…”
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