Search Results - "Gu, Yihui"
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Genotype-phenotype correlations and treatment innovation of neurofibromatosis type 1 (NF1): Current understanding and perspective
Published in Chinese medical journal (20-07-2024)“…[11] In phase II, 74% (37/50) of the participants achieved PR, and the overall response rate reached 68%, indicating that there was at least one improvement in…”
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Photonic hyperthermia of malignant peripheral nerve sheath tumors at the third near-infrared biowindow
Published in eLife (16-09-2022)“…Background: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that typically carry a dismal prognosis. Given the insensitivity of these…”
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Concurrent inhibition of FAK/SRC and MEK overcomes MEK inhibitor resistance in Neurofibromatosis Type I related malignant peripheral nerve sheath tumors
Published in Frontiers in oncology (29-07-2022)“…Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft-tissue sarcomas which lack effective drugs. Loss of the RAS GTPase-activating protein NF1…”
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RRM2 as a novel prognostic and therapeutic target of NF1-associated MPNST
Published in Cellular oncology (Dordrecht) (01-10-2023)“…Background Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that typically develop in the setting of neurofibromatosis type 1 (NF1)…”
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Analysis of the current Covid-19 infection and vaccination status in patients with neurofibromatosis type 1
Published in Chinese journal of plastic and reconstructive surgery (01-03-2023)“…To investigate the common symptoms after Covid-19 infection, characteristics of adverse events after vaccination, changes in clinical manifestations related to…”
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Preclinical Assessment of MEK Inhibitors for Malignant Peripheral Nerve Sheath Tumors Reveals Differences in Efficacy and Adaptive Response
Published in Frontiers in oncology (07-07-2022)“…Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft-tissue sarcomas refractory to standard therapies. Inactivation of NF1 and subsequent…”
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History and prospect of melanocytic nevus treatment: A bibliometric analysis
Published in Chinese journal of plastic and reconstructive surgery (01-12-2023)“…Melanocytic nevus is mainly treated by complete or partial removal. However, predicting the risk of malignant transformation of melanocytic nevi and which…”
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Distribution Patterns (7B Rule) and Characteristics of Large Congenital Melanocytic Nevi: A Retrospective Cohort Study in China
Published in Frontiers in medicine (19-02-2021)“…Large congenital melanocytic nevus has a high risk of malignancy. However, few studies have summarized its characteristics, treatments, outcomes and malignancy…”
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Percutaneous endoscopy in direct real-time observation of choke vessels in rat perforator flap model
Published in JPRAS open (01-06-2019)“…Most of the techniques used to investigate choke vessels are indirect. The aim of the present study is to assess the effectiveness of percutaneous endoscopy in…”
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Lignin-induced sacrificial conjoined-network enabled strong and tough chitosan membrane for food preservation
Published in Carbohydrate polymers (01-08-2023)“…As a natural green polymer, chitosan is a promising material for plastic replacement. However, the mutually exclusive strength and toughness severely limit its…”
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Genotype–phenotype correlations of neurofibromatosis type 1: a cross-sectional study from a large Chinese cohort
Published in Journal of neurology (01-04-2024)“…Background Neurofibromatosis type 1 (NF1) is a highly heterogeneous autosomal genetic disorder characterized by a broad spectrum of clinical and molecular…”
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Multi‐Solvent‐Induced Gradient Aggregation Rendered Superstrong, Tough, Stretchable, and Fatigue‐Resistant Lignin‐Based Supramolecular Hydrogels
Published in Advanced functional materials (16-11-2024)“…Abstract A hydrogel that is expected as a biomedical load‐bearing material remains a substantial challenge. In this work, a multi‐solvent‐induced gradient…”
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Multifunctional chemoreactive nanosonosensitizers exert antitumoral, antibacterial and wound healing effects on malignant peripheral nerve sheath tumors
Published in Chemical engineering journal (Lausanne, Switzerland : 1996) (01-12-2023)“…[Display omitted] •A multifunctional in situ chemoreactive nanosonosensitizer of DSF-CuO2@DMSN.•Combined sonodynamic/chemodynamic/chemotherapeutic treatment to…”
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Reduced PTPRS expression promotes epithelial-mesenchymal transition of Schwann cells in NF1-related plexiform neurofibromas
Published in Cancer letters (01-09-2024)“…Plexiform neurofibromas (PNFs) are a prevalent and severe phenotype associated with NF1, characterized by a high teratogenic rate and potential for malignant…”
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FOXM1 promotes neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor progression in a NUF2-dependent manner
Published in Cancer gene therapy (01-10-2023)“…Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft-tissue sarcomas characterized by poor prognosis and low drug response rates. Traditional…”
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The role of macrophages in the formation of hypertrophic scars and keloids
Published in Burns and trauma (01-01-2020)“…Abstract Numerous studies have shown that macrophages can orchestrate the microenvironment from the early stage of wound healing to the later stages of scar…”
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Tensions and Rewards: Behind the Scenes in a Cross-Cultural Student-Staff Partnership
Published in Journal of studies in international education (01-02-2019)“…In the domain of "internationalization of the curriculum," this article introduces the rarely incorporated dimension of "engaging students as partners" (SaP)…”
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Knockdown of NCOR2 Inhibits Cell Proliferation via BDNF/TrkB/ERK in NF1-Derived MPNSTs
Published in Cancers (24-11-2022)“…(1) Background: malignant peripheral nerve sheath tumours (MPNSTs) are aggressive Schwann cell-derived sarcomas with dismal prognoses. Previous studies have…”
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A lignin-based controlled/sustained release hydrogel by integrating mechanical strengthening and bioactivities of lignin
Published in Journal of Bioresources and Bioproducts (01-10-2024)Get full text
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Macrophage migration inhibitory factor (MIF) inhibitor, Z-590 suppresses cartilage destruction in adjuvant-induced arthritis via inhibition of macrophage inflammatory activation
Published in Immunopharmacology and immunotoxicology (04-03-2018)“…Background: Macrophage migration inhibitory factor (MIF) is a pleiotropic pro-inflammatory mediator that is involved in the progression of rheumatoid arthritis…”
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