Search Results - "Gu, Xiaoxia"

Rational Design and Synthesis of Novel Dual PROTACs for Simultaneous Degradation of EGFR and PARP by Zheng, Mengzhu, Huo, Junfeng, Gu, Xiaoxia, Wang, Yali, Wu, Canrong, Zhang, Qingzhe, Wang, Wang, Liu, Yang, Liu, Yu, Zhou, Xuechen, Chen, Lixia, Zhou, Yirong, Li, Hua

“…Inspired by the success of dual-targeting drugs, especially bispecific antibodies, we propose to combine the concept of proteolysis targeting chimera (PROTAC)…”
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Ziprasidone suppresses pancreatic adenocarcinoma cell proliferation by targeting GOT1 to trigger glutamine metabolism reprogramming by Yang, Yueying, Zheng, Mengzhu, Han, Fei, Shang, Lei, Li, Mingxue, Gu, Xiaoxia, Li, Hua, Chen, Lixia

“…Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignant tumor whose effective treatment has not been found. The redox state and proliferative activity of…”
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Financial Strain and Intimate Partner Violence Against Married Women in Postreform China: Evidence From Chengdu by Zheng, Li, Xu, Xiaohe, Xu, Ting, Yang, Liu, Gu, Xiaoxia, Wang, Lijuan

“…The primary goal of this study is to link both subjective and objective indicators of financial strain to two distinct dimensions of intimate partner violence…”
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Furin: A Potential Therapeutic Target for COVID-19 by Wu, Canrong, Zheng, Mengzhu, Yang, Yueying, Gu, Xiaoxia, Yang, Kaiyin, Li, Mingxue, Liu, Yang, Zhang, Qingzhe, Zhang, Peng, Wang, Yali, Wang, Qiqi, Xu, Yang, Zhou, Yirong, Zhang, Yonghui, Chen, Lixia, Li, Hua

“…COVID-19 broke out in the end of December 2019 and is still spreading rapidly, which has been listed as an international concerning public health emergency. We…”
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The Relationship between Family Factors and Academic Achievement of Junior High School Students in Rural China: Mediation Effect of Parental Involvement by Gu, Xiaoxia, Hassan, Norlizah Che, Sulaiman, Tajularipin

“…This study aims to understand how socioeconomic status and the family environment impact students' academic achievement through the mediation of parental…”
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Propofol-induced MiR-20b expression initiates endogenous cellular signal changes mitigating hypoxia/re-oxygenation-induced endothelial autophagy in vitro by Lu, Yue, Wang, Sijie, Cai, Shuyun, Gu, Xiaoxia, Wang, Jingjing, Yang, Yue, Hu, Zhe, Zhang, Xihe, Ye, Yongcai, Shen, Siman, Joshi, Kiran, Ma, Daqing, Zhang, Liangqing

“…Certain miRNAs can attenuate hypoxia/re-oxygenation-induced autophagic cell death reported in our previous studies, but how these miRNAs regulate the…”
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Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma by Lei, Kecheng, Gu, Xiaoxia, Alvarado, Alvaro G, Du, Yuhong, Luo, Shilin, Ahn, Eun Hee, Kang, Seong Su, Ji, Bing, Liu, Xia, Mao, Hui, Fu, Haian, Kornblum, Harley I, Jin, Lingjing, Li, Hua, Ye, Keqiang

“…Glioblastoma (GBM) is a universally lethal tumor with frequently overexpressed or mutated epidermal growth factor receptor (EGFR). NADPH quinone oxidoreductase…”
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Rational design of AIE-based carbazole derivatives for lipid droplet-specific imaging in living cells by Wang, Hui, Shen, Xuebin, Ge, Jiayi, Deng, Yi, Ding, Feiyang, Wang, Zhiyu, Zhu, Wenya, Hu, Lei, He, Jing, Gu, Xiaoxia

“…The visualization of lipid droplets (LDs) plays a significant role in understanding relevant diseases. Herein, a sequence of novel carbazole derivatives (…”
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Effects of Ionic Liquids on Piezoelectric Properties of Electrospun Poly(L‑lactic acid) Nanofiber Membranes by Gu, Xiaoxia, Cui, Meng, Wang, Bin, Liu, Guyue, Zhang, Jing, Wang, Rui, Zhang, Xiuqin

“…The development of environmentally friendly, degradable piezoelectric materials is of great significance for the environment. Poly­(L-lactic acid) (PLLA) is a…”
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Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling by Zhang, Xiaojun, Wang, Changsen, Xu, Hao, Cai, Shuyun, Liu, Keyu, Li, Simeng, Chen, Linming, Shen, Siman, Gu, Xiaoxia, Tang, Jing, Xia, Zhengyuan, Hu, Zhe, Ma, Xiaotang, Zhang, Liangqing

“…Ischemia-reperfusion (IR) induces increased release of extracellular vesicles in the heart and exacerbates myocardial IR injury. We have previously shown that…”
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The clinical effect of dexmedetomidine combined with parecoxib sodium on sedation, antianxiety and prevention of intubation stress in patients undergoing functional endoscopic sinus surgery: a randomised controlled trial by Gu, Xiaoxia, Tan, Xiujuan, Chen, Jinxian, Wang, Jingjing, Lu, Yue, Zhang, Liangqing

“…Abstract Background To investigate the effect of intravenous injection of dexmedetomidine combined with parecoxib sodium on sedation and anxiety and stress…”
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Effects of incorporation of nano-fluorapatite or nano-fluorohydroxyapatite on a resin-modified glass ionomer cement by Lin, Jun, Zhu, Jiajun, Gu, Xiaoxia, Wen, Wenjian, Li, Qingshan, Fischer-Brandies, Helge, Wang, Huiming, Mehl, Christian

“…This study aimed to investigate the fluoride release properties and the effect on bond strength of two experimental adhesive cements. Synthesized particles of…”
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Ischemic postconditioning downregulates Egr-1 expression and attenuates postischemic pulmonary inflammatory cytokine release and tissue injury in rats by Wu, Huozhi, MD, PhD, Lei, Shaoqing, MD, PhD, Yuan, Jiang, MD, Liu, Xin, MD, MSc, Zhang, Dayong, MD, Gu, Xiaoxia, MD, Zhang, Liangqing, MD, PhD, Xia, Zhengyuan, MD, PhD

“…Abstract Background The early growth response-1 (Egr-1) gene is upregulated after an ischemia–reperfusion (IR) challenge and upregulates target genes, such as…”
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Synthesis, structure, and catalytic activity of rare-earth metal amides with a neutral pyrrolyl-functionalized indolyl ligand by Yang, Song, Zhu, XianCui, Zhou, ShuangLiu, Wang, ShaoWu, Feng, ZhiJun, Wei, Yun, Miao, Hui, Guo, LiPing, Wang, FenHua, Zhang, GuangChao, Gu, XiaoXia, Mu, XiaoLong

“…The reactions of neutral pyrrolyl-functionalized indole with rare-earth metal amides [（Me3Si）2N]3RE（μ-Cl）Li（THF）3 produced the rare-earth metal complexes…”
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Highly Regio- and Stereoselective Synthesis of Tetrasubstituted Olefins by the Three-Component Tandem Reaction of Allylzinc Bromide, Acetylenic Sulfone, and Halohydrocarbon by Xie, Meihua, Wang, Jialiang, Gu, Xiaoxia, Sun, Ying, Wang, Shaowu

“…Tetrasubstituted olefins containing a 1,4-diene structural unit can be regio- and stereoselectively constructed in one pot by the allylzincation of acetylenic…”
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Polarity-sensitive and lipid droplet-specific red emission fluorophore for identifying fatty liver of living mice through in vivo imaging by Hu, Lei, Pan, Jin, Zhang, Cuifeng, Yu, Kun, Shen, Shuting, Wang, Yaxuan, Shen, Xuebin, Gu, Xiaoxia, Han, Jun, Wang, Hui

“…The illustration of the correlation between lipid droplets (LDs) variation and nonalcoholic fatty liver disease (NAFLD) is a challenging and important work in…”
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The development of New Delhi metallo-β-lactamase-1 inhibitors since 2018 by Gu, Xiaoxia, Zheng, Mengzhu, Chen, Lixia, Li, Hua

“…New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze almost all antibiotics of the β-lactam group, resulting in the generation of multidrug resistant…”
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The impact of video game playing on Chinese adolescents’ academic achievement: Evidence from a moderated multi-mediation model by Gu, Xiaoxia, Hassan, Norlizah Che, Sulaiman, Tajularipin, Wei, Zhixia, Dong, Jingyi

“…Internet access for adolescents is becoming more prevalent around the world. Although video game playing has been verified to be negatively related to…”
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Multifunctional lipid droplet probes for observing the polarity change of ferroptosis, inflammation, fatty liver and evaluating the efficacy of drugs by Yang, Jing, Wang, Yuqing, Wang, Zhiyu, Wang, Jie, Zhang, Cuifeng, Gu, Xiaoxia, Hu, Lei, Wang, Hui

“…Lipid droplets (LDs) polarity is intricately linked to diverse biological processes and diseases. The visualization of LDs-polarity is of vital importance but…”
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Boronate-based fluorescence probes image viscosity and hydrogen peroxide in living cells by Wang, Chunfei, Hu, Lei, Yang, Jing, Wang, Yuqing, Chen, Xi, Gu, Xiaoxia, Wang, Hui

“…•Boronate-based fluorescence probes (L1-L3) were developed for imaging viscosity and H2O2.•N-hydroxyethyl substitution has almost no effect on the TICT…”
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