Search Results - "Gu, Xiaohuan"

Regulation of Therapeutic Hypothermia on Inflammatory Cytokines, Microglia Polarization, Migration and Functional Recovery after Ischemic Stroke in Mice by Lee, Jin Hwan, Wei, Zheng Z, Cao, Wenyuan, Won, Soonmi, Gu, Xiaohuan, Winter, Megan, Dix, Thomas A, Wei, Ling, Yu, Shan Ping

“…Abstract Stroke is a leading threat to human life and health in the US and around the globe, while very few effective treatments are available for stroke…”
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Optochemogenetic Stimulation of Transplanted iPS-NPCs Enhances Neuronal Repair and Functional Recovery after Ischemic Stroke by Yu, Shan Ping, Tung, Jack K, Wei, Zheng Z, Chen, Dongdong, Berglund, Ken, Zhong, Weiwei, Zhang, James Y, Gu, Xiaohuan, Song, Mingke, Gross, Robert E, Lin, Shinn Z, Wei, Ling

“…Cell transplantation therapy provides a regenerative strategy for neural repair. We tested the hypothesis that selective excitation of transplanted induced…”
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Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α by Ogle, Molly E, Gu, Xiaohuan, Espinera, Alyssa R, Wei, Ling

“…Abstract Pathological oxygen deprivation inhibits prolyl hydroxylase (PHD) activity and stimulates a protective cellular oxygen-sensing response in part…”
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Optogenetic stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice by Song, Mingke, Yu, Shan Ping, Mohamad, Osama, Cao, Wenyuan, Wei, Zheng Zachory, Gu, Xiaohuan, Jiang, Michael Qize, Wei, Ling

“…Neurogenesis in the subventricular zone (SVZ) of the adult brain may contribute to tissue repair after brain injuries. Whether SVZ neurogenesis can be…”
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DL-3-n-butylphthalide induced neuroprotection, regenerative repair, functional recovery and psychological benefits following traumatic brain injury in mice by Zhao, Yingying, Lee, Jin Hwan, Chen, Dongdong, Gu, Xiaohuan, Caslin, Asha, Li, Jimei, Yu, Shan Ping, Wei, Ling

“…Previous investigations suggest that DL-3-n-butylphthalide (NBP) is a promising multifaceted drug for the treatment of stroke. It is not clear whether NBP can…”
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Enhanced Neurogenesis and Collaterogenesis by Sodium Danshensu Treatment After Focal Cerebral Ischemia in Mice by Wei, Zheng Zachory, Chen, Dongdong, Liu, Li-Ping, Gu, Xiaohuan, Zhong, Weiwei, Zhang, Yong-Bo, Wang, Yongjun, Yu, Shan Ping, Wei, Ling

“…Ischemic stroke remains a serious threat to human life. There are limited effective therapies for the treatment of stroke. We have previously demonstrated that…”
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Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice by Chen, Dongdong, Wei, Ling, Liu, Zhi-Ren, Yang, Jenny J., Gu, Xiaohuan, Wei, Zheng Z., Liu, Li-Ping, Yu, Shan Ping

“…Ischemic stroke remains a serious threat to human life. Generation of neuronal and vascular cells is an endogenous regenerative mechanism in the adult brain,…”
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Intranasal Delivery of Apelin-13 Is Neuroprotective and Promotes Angiogenesis After Ischemic Stroke in Mice by Chen, Dongdong, Lee, Jinhwan, Gu, Xiaohuan, Wei, Ling, Yu, Shan Ping

“…Apelin is a peptide originally isolated from bovine stomach tissue extracts and identified as an endogenous ligand of the APJ receptor; recent work showed that…”
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iPSC Transplantation Increases Regeneration and Functional Recovery After Ischemic Stroke in Neonatal Rats by Chau, Monica J., Deveau, Todd C., Song, Mingke, Gu, Xiaohuan, Chen, Dongdong, Wei, Ling

“…Limited treatments are available for perinatal/neonatal stroke. Induced pluripotent stem cells (iPSCs) hold therapeutic promise for stroke treatment, but the…”
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Delayed intranasal delivery of hypoxic-preconditioned bone marrow mesenchymal stem cells enhanced cell homing and therapeutic benefits after ischemic stroke in mice by Wei, Ning, Yu, Shan Ping, Gu, Xiaohuan, Taylor, Tammi M, Song, Denise, Liu, Xin-Feng, Wei, Ling

“…Stem cell transplantation therapy has emerged as a potential treatment for ischemic stroke and other neurodegenerative diseases. Effective delivery of…”
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Long‐term survival and regeneration of neuronal and vasculature cells inside the core region after ischemic stroke in adult mice by Jiang, Michael Qize, Zhao, Ying‐Ying, Cao, Wenyuan, Wei, Zheng Zachory, Gu, Xiaohuan, Wei, Ling, Yu, Shan Ping

“…Focal cerebral ischemia results in an ischemic core surrounded by the peri‐infarct region (penumbra). Most research attention has been focused on penumbra…”
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Delayed and repeated intranasal delivery of bone marrow stromal cells increases regeneration and functional recovery after ischemic stroke in mice by Chau, Monica J, Deveau, Todd C, Gu, Xiaohuan, Kim, Yo Sup, Xu, Yun, Yu, Shan Ping, Wei, Ling

“…Stroke is a leading cause of death and disability worldwide, yet there are limited treatments available. Intranasal administration is a novel non-invasive…”
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Intranasal delivery of bone marrow mesenchymal stem cells improved neurovascular regeneration and rescued neuropsychiatric deficits after neonatal stroke in rats by Wei, Zheng Zachory, Gu, Xiaohuan, Ferdinand, Anwar, Lee, Jin Hwan, Ji, Xiaoya, Ji, Xun Ming, Yu, Shan Ping, Wei, Ling

“…Neonatal stroke is a major cause of mortality and long-term morbidity in infants and children. Currently, very limited therapeutic strategies are available to…”
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Restoration of intracortical and thalamocortical circuits after transplantation of bone marrow mesenchymal stem cells into the ischemic brain of mice by Song, Mingke, Mohamad, Osama, Gu, Xiaohuan, Wei, Ling, Yu, Shan Ping

“…Transplantation of bone marrow mesenchymal stem cells (BMSCs) provides a promising regenerative medicine for stroke. Whether BMSC therapy could repair…”
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Pharmacologically induced hypothermia attenuates traumatic brain injury in neonatal rats by Gu, Xiaohuan, Wei, Zheng Zachory, Espinera, Alyssa, Lee, Jin Hwan, Ji, Xiaoya, Wei, Ling, Dix, Thomas A., Yu, Shan Ping

“…Neonatal brain trauma is linked to higher risks of mortality and neurological disability. The use of mild to moderate hypothermia has shown promising potential…”
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Conversion of Reactive Astrocytes to Induced Neurons Enhances Neuronal Repair and Functional Recovery After Ischemic Stroke by Jiang, Michael Qize, Yu, Shan Ping, Wei, Zheng Zachory, Zhong, Weiwei, Cao, Wenyuan, Gu, Xiaohuan, Wu, Anika, McCrary, Myles Randolph, Berglund, Ken, Wei, Ling

“…The master neuronal transcription factor NeuroD1 can directly reprogram astrocytes into induced neurons (iNeurons) after stroke. Using viral vectors to drive…”
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Intracranial Transplantation of Hypoxia-Preconditioned iPSC-Derived Neural Progenitor Cells Alleviates Neuropsychiatric Defects After Traumatic Brain Injury in Juvenile Rats by Wei, Zheng Zachory, Lee, Jin Hwan, Zhang, Yongbo, Zhu, Yan Bing, Deveau, Todd C, Gu, Xiaohuan, Winter, Megan M, Li, Jimei, Wei, Ling, Yu, Shan Ping

“…Traumatic brain injury (TBI) is a common cause of mortality and long-term morbidity in children and adolescents. Posttraumatic stress disorder (PTSD)…”
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Reprogramming Glioblastoma Cells into Non-Cancerous Neuronal Cells as a Novel Anti-Cancer Strategy by Jiang, Michael Q, Yu, Shan Ping, Estaba, Takira, Choi, Emily, Berglund, Ken, Gu, Xiaohuan, Wei, Ling

“…Glioblastoma Multiforme (GBM) is an aggressive brain tumor with a high mortality rate. Direct reprogramming of glial cells to different cell lineages, such as…”
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Neuropsychological Deficits Chronically Developed after Focal Ischemic Stroke and Beneficial Effects of Pharmacological Hypothermia in the Mouse by Zhong, Weiwei, Yuan, Yan, Gu, Xiaohuan, Kim, Samuel In-Young, Chin, Ryan, Loye, Modupe, Dix, Thomas A, Wei, Ling, Yu, Shan Ping

“…Stroke is a leading cause of human death and disability, with around 30% of stroke patients develop neuropsychological/neuropsychiatric symptoms, such as…”
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Modulation of Stem Cells as Therapeutics for Severe Mental Disorders and Cognitive Impairments by Zhang, Yongbo, Zhao, Yingying, Song, Xiaopeng, Luo, Hua, Sun, Jinmei, Han, Chunyu, Gu, Xiaohuan, Li, Jun, Cai, Guilan, Zhu, Yanbing, Liu, Zhandong, Wei, Ling, Wei, Zheng Zachory

“…Severe mental illnesses (SMI) such as schizophrenia and bipolar disorder affect 2-4% of the world population. Current medications and diagnostic methods for…”
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