Search Results - "Gu, Weiwang"

Salvianolic Acid B Alleviates Heart Failure by Inactivating ERK1/2/GATA4 Signaling Pathway after Pressure Overload in Mice by Yu, Juan, Chen, Renshan, Tan, Yafang, Wu, Jiashin, Qi, Jianyong, Zhang, Minzhou, Gu, Weiwang

“…Heart failure(HF) is a dangerous disease that affects millions of patients. Radix Salvia is widely used in Chinese clinics to treat heart diseases. Salvianolic…”
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KLF4 Promotes Angiogenesis by Activating VEGF Signaling in Human Retinal Microvascular Endothelial Cells by Wang, Yinan, Yang, Chuanhe, Gu, Qingqing, Sims, Michelle, Gu, Weiwang, Pfeffer, Lawrence M, Yue, Junming

“…The transcription factor Krüppel-like factor 4 (KLF4) has been implicated in regulating cell proliferation, migration and differentiation in a variety of human…”
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Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs by Yang, Dongshan, Wang, Chuan-En, Zhao, Bentian, Li, Wei, Ouyang, Zhen, Liu, Zhaoming, Yang, Huaqiang, Fan, Pei, O'Neill, Ashley, Gu, Weiwang, Yi, Hong, Li, Shihua, Lai, Liangxue, Li, Xiao-Jiang

“…Neurodegeneration is a hallmark of many neurological diseases, including Alzheimer's, Parkinson's and the polyglutamine diseases, which are all caused by…”
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EDIII-Fc induces protective immune responses against the Zika virus in mice and rhesus macaque by Hailong, Su, Liu, Jun, Yu, Jianhai, Qiu, Zhenzhen, Liang, Wenhan, Wu, Wangsheng, Mo, Haifeng, Li, Hongwei, Zhao, Wei, Gu, Weiwang

“…Zika virus can infect the fetus through the placental barrier, causing ZIKV congenital syndrome and even miscarriage, which can cause great harm to pregnant…”
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Doxycycline inducible Krüppel-like factor 4 lentiviral vector mediates mesenchymal to epithelial transition in ovarian cancer cells by Chen, Zixuan, Wang, Yinan, Liu, Wen, Zhao, Guannan, Lee, Suechin, Balogh, Andrea, Zou, Yanan, Guo, Yuqi, Zhang, Zhan, Gu, Weiwang, Li, Chengyao, Tigyi, Gabor, Yue, Junming

“…Ovarian cancer presents therapeutic challenges due to its typically late detection, aggressive metastasis, and therapeutic resistance. The transcription factor…”
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Use of the 2A peptide for generation of multi-transgenic pigs through a single round of nuclear transfer by Deng, Wei, Yang, Dongshan, Zhao, Bentian, Ouyang, Zhen, Song, Jun, Fan, Nana, Liu, Zhaoming, Zhao, Yu, Wu, Qinghong, Nashun, Bayaer, Tang, Jiangjing, Wu, Zhenfang, Gu, Weiwang, Lai, Liangxue

“…Multiple genetic modifications in pigs can essentially benefit research on agriculture, human disease and xenotransplantation. Most multi-transgenic pigs have…”
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Intramuscular Injection of Exogenous Leptin Induces Adiposity, Glucose Intolerance and Fatty Liver by Repressing the JAK2-STAT3/PI3K pathway in a Rat Model by Wu, Lihong, Chen, Guoxiong, Liu, Wen, Yang, Xuechao, Gao, Jie, Huang, Liwen, Guan, Hongbing, Li, Zhengmao, Zheng, Zhichao, Li, Meiling, Gu, Weiwang, Ge, Linhu

“…Graphical abstract…”
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miRNA biogenesis enzyme Drosha is required for vascular smooth muscle cell survival by Fan, Pei, Chen, Zixuan, Tian, Peng, Liu, Wen, Jiao, Yan, Xue, Yi, Bhattacharya, Anindya, Wu, Jianmin, Lu, Meifen, Guo, Yuqi, Cui, Yan, Gu, Weikuan, Gu, Weiwang, Yue, Junming

“…miRNA biogenesis enzyme Drosha cleaves double-stranded primary miRNA by interacting with double-stranded RNA binding protein DGCR8 and processes primary miRNA…”
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Genetically blocking HPD via CRISPR-Cas9 protects against lethal liver injury in a pig model of tyrosinemia type I by Gu, Peng, Yang, Qin, Chen, Bangzhu, Bie, Ya-nan, Liu, Wen, Tian, Yuguang, Luo, Hongquan, Xu, Tao, Liang, Chunjin, Ye, Xing, Liu, Yan, Tang, Xiangwu, Gu, Weiwang

“…Hereditary tyrosinemia type I (HT1) results from the loss of fumarylacetoacetate hydrolase (FAH) activity and can lead to lethal liver injury (LLI)…”
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A porcine brain-wide RNA editing landscape by Huang, Jinrong, Lin, Lin, Dong, Zhanying, Yang, Ling, Zheng, Tianyu, Gu, Weiwang, Zhang, Yan, Yin, Tailang, Sjöstedt, Evelina, Mulder, Jan, Uhlén, Mathias, Kristiansen, Karsten, Bolund, Lars, Luo, Yonglun

“…Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is an essential post-transcriptional modification. Although hundreds of thousands of RNA…”
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Optimization Strategy for Generating Gene-edited Tibet Minipigs by Synchronized Oestrus and Cytoplasmic Microinjection by Chen, Bangzhu, Gu, Peng, Jia, Junshuang, Liu, Wei, Liu, Yumin, Liu, Wen, Xu, Tao, Lin, Xiaolin, Lin, Taoyan, Liu, Yu, Chen, Hengwei, Xu, Mingchen, Yuan, Jin, Zhang, Jianing, Zhang, Yinghui, Xiao, Dong, Gu, Weiwang

“…The Tibet minipig is a rare highland pig breed worldwide and has many applications in biomedical and agricultural research. However, Tibet minipigs are not…”
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Gene expression profiling associated with angiotensin II type 2 receptor-induced apoptosis in human prostate cancer cells by Pei, Nana, Jie, Feilong, Luo, Jie, Wan, Renqiang, Zhang, Yanling, Chen, Xinglu, Liang, Zhibing, Du, Hongyan, Li, Andrew, Chen, Baihong, Zhang, Yi, Sumners, Colin, Li, Jinlong, Gu, Weiwang, Li, Hongwei

“…Increased expression of angiotensin II type 2 receptor (AT2R) induces apoptosis in numerous tumor cell lines, with either Angiotensin II-dependent or…”
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Production of transgenic pigs over-expressing the antiviral gene Mx1 by Yan, Quanmei, Yang, Huaqiang, Yang, Dongshan, Zhao, Bentian, Ouyang, Zhen, Liu, Zhaoming, Fan, Nana, Ouyang, Hongsheng, Gu, Weiwang, Lai, Liangxue

“…The myxovirus resistance gene (Mx1) has a broad spectrum of antiviral activities. It is therefore an interesting candidate gene to improve disease resistance…”
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Zika Virus Envelope Protein induces G2/M Cell Cycle Arrest and Apoptosis via an Intrinsic Cell Death Signaling Pathway in Neuroendocrine PC12 Cells by Liu, Jun, Li, Qingqing, Li, Xiaoxin, Qiu, Zhenzhen, Li, Andrew, Liang, Wenhan, Chen, Huangyao, Cai, Xiangsheng, Chen, Xinglu, Duan, Xinyue, Li, Jingjing, Wu, Wangsheng, Xu, Mingyu, Mao, Yingying, Chen, Huiying, Li, Jinlong, Gu, Weiwang, Li, Hongwei

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Establishment of a porcine Oct-4 promoter-driven EGFP reporter system for monitoring pluripotency of porcine stem cells by Huang, Lizhen, Fan, Nana, Cai, Jie, Yang, Dongshan, Zhao, Bentian, Ouyang, Zhen, Gu, Weiwang, Lai, Liangxue

“…Porcine pluripotent cells with the capacity to generate germ line chimeras have not been developed yet. The transcription factor Oct-4 is an important marker…”
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Exogenous Leptin Administered Intramuscularly Induces Sex Hormone Disorder and Ca Loss via Downregulation of Gnrh and PI3K Expression by Wu, Lihong, LIU, Wen, BAYAER, Nashun, GU, Weiwang, SONG, Jieli

“…Obesity is a public health problem that increases the risk of metabolic disease, infertility, and other chronic health problems. The present study aimed to…”
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Integration of 16S rRNA gene sequencing and LC/MS-based metabolomic analysis of early biomarkers of acute ischaemic stroke in Tibetan miniature pigs by Guan, Yajin, Liu, Tianping, Xu, Fei, Xie, Shuilin, Gu, Weiwang, Bie, Yanan

“…Acute ischaemic stroke (AIS) is a complex, systemic, pathological, and physiological process. Systemic inflammatory responses and disorders of the gut…”
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Gut Microbial Compositions in Four Age Groups of Tibetan Minipigs by Jiang, Xia, Chen, Bangzhu, Gu, Dongshu, Rong, Zuhua, Su, Xiaohua, Yue, Min, Zhou, Hongwei, Gu, Weiwang

“…In this study, the gut microbiota was characterized in four age strata of Tibetan minipigs. Results indicated that the fecal bacteria of 7-, 28-, 56-, and…”
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Exogenous Leptin Administered Intramuscularly Induces Sex Hormone Disorder and Ca Loss via Downregulation of Gnrh and PI3K Expression by Wu, Lihong, LIU, Wen, BAYAER, Nashun, GU, Weiwang, SONG, Jieli

“…Obesity is a public health problem that increases the risk of metabolic disease, infertility, and other chronic health problems. The present study aimed to…”
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Efficient Gene Transfer to Kidney Using a Lentiviral Vector Pseudotyped with Zika Virus Envelope Glycoprotein by Liu, Jun, Mao, Yingying, Li, Qingqing, Qiu, Zhenzhen, Li, Jingjing, Li, Xiaoxin, Liang, Wenhan, Xu, Mingyu, Li, Andrew, Cai, Xiangsheng, Wu, Wangsheng, Chen, Huangyao, Yan, Renhe, Li, Jinlong, Gu, Weiwang, Li, Hongwei

“…Gene therapy's entrance into clinical settings has made it an ever more attractive field of study for various diseases. However, relatively little progress has…”
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