Search Results - "Gu, Lubing"

Mutual regulation of MDM4 and TOP2A in cancer cell proliferation by Liu, Tao, Zhang, Hailong, Yi, Sha, Gu, Lubing, Zhou, Muxiang

“…MDM4 and topoisomerase IIα (TOP2A) are overexpressed in various human cancers. MDM4 acts as an oncoprotein which promotes cancer progression by inhibiting…”
Get full text

Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice by Gu, Lubing, Zhang, Hailong, Liu, Tao, Draganov, Alexander, Yi, Sha, Wang, Binghe, Zhou, Muxiang

“…A novel small-molecule anthraquinone (AQ) analogue, AQ-101, which was synthesized through chemical modification of the core structures of rhein, exhibited…”
Get full text

MDM2 Regulates Vascular Endothelial Growth Factor mRNA Stabilization in Hypoxia by Zhou, Sheng, Gu, Lubing, He, Jing, Zhang, Hailong, Zhou, Muxiang

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Degradation of MDM2 by the Interaction between Berberine and DAXX Leads to Potent Apoptosis in MDM2-Overexpressing Cancer Cells by XIAOLING ZHANG, LUBING GU, JIANSHA LI, SHAH, Noopur, JING HE, LIN YANG, QUN HU, MUXIANG ZHOU

“…Berberine, a natural product derived from a plant used in Chinese herbal medicine, is reported to exhibit anticancer effects; however, its mechanism of action…”
Get full text

Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway by Huang, Mei, Zhang, Hailong, Liu, Tao, Tian, Dan, Gu, Lubing, Zhou, Muxiang

“…Triptolide, a natural product derived from the Chinese plant Tripterygium wilfordii, is reported to exhibit antitumor effects in a broad range of cancers. The…”
Get full text

MYCN mRNA degradation and cancer suppression by a selective small-molecule inhibitor in MYCN-amplified neuroblastoma by Liu, Tao, Gu, Lubing, Wu, Zhongzhi, Albadari, Najah, Li, Wei, Zhou, Muxiang

“…Amplification of the gene leads to its overexpression at both the mRNA and protein levels. Overexpression of mRNA may also have an important role in promoting…”
Get full text

Inhibition of MDM2 by nilotinib contributes to cytotoxicity in both Philadelphia-positive and negative acute lymphoblastic leukemia by Zhang, Hailong, Gu, Lubing, Liu, Tao, Chiang, Kuang-Yueh, Zhou, Muxiang

“…Nilotinib is a selective BCR-ABL tyrosine kinase inhibitor related to imatinib that is more potent than imatinib. Nilotinib is widely used to treat chronic…”
Get full text

Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells by Zhu, Ningxi, Gu, Lubing, Li, Fengzhi, Zhou, Muxiang

“…The phosphatidylinositol 3-kinase (PI3K)/Akt and p53 pathways play antiapoptotic and proapoptotic roles in cell death, respectively. Cancer cell growth and…”
Get full text

KLF5 Interacts with p53 in Regulating Survivin Expression in Acute Lymphoblastic Leukemia by Zhu, Ningxi, Gu, Lubing, Findley, Harry W., Chen, Ceshi, Dong, Jin-Tang, Yang, Lily, Zhou, Muxiang

“…The Kruppel-like factor 5 (KLF5) is a transcription factor that regulates cellular signaling involved in cell proliferation and oncogenesis. Here, we report…”
Get full text

Berberine represses DAXX gene transcription and induces cancer cell apoptosis by Li, Jiansha, Gu, Lubing, Zhang, Hailong, Liu, Tao, Tian, Dan, Zhou, Muxiang, Zhou, Sheng

Get full text

MDM2 induces NF-κB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia by Gu, Lubing, Findley, Harry W., Zhou, Muxiang

“…MDM2 protein is thought to exhibit tumorigenic activity by binding to the p53 tumor-suppressor protein and inhibiting its function. Alternatively, MDM2 may…”
Get full text

Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastoma by He, Jing, Gu, Lubing, Zhang, Hailong, Zhou, Muxiang

“…Previous studies show that the MYCN and MDM2-p53 signal pathways are mutually regulated: MYCN stimulates MDM2 and p53 transcription, whereas MDM2 stabilizes…”
Get full text

An alternatively spliced survivin variant is positively regulated by p53 and sensitizes leukemia cells to chemotherapy by NINGXI ZHU, LUBING GU, FINDLEY, Harry W, FENGZHI LI, MUXIANG ZHOU

“…Survivin is a unique member of the inhibitor of apoptosis protein family, and its expression is regulated by p53. Recent identification of several functionally…”
Get full text

Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53 by MUXIANG ZHOU, LUBING GU, NINGXI ZHU, WOODS, William G, FINDLEY, Harry W

“…To investigate the possible role of inhibiting NF-kB activation in sensitizing tumor cells to chemotherapy-induced apoptosis, we transfected the…”
Get full text

PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells by MUXIANG ZHOU, LUBING GU, FINDLEY, Harry W, RONG JIANG, WOODS, William G

“…The tumor suppressor PTEN has been associated with the cellular localization of MDM2 in regulation of apoptosis through inhibiting PI3k/Akt signaling. To…”
Get full text

DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells by Zhou, Muxiang, Gu, Lubing, Li, Fengzhi, Zhu, Yerun, Woods, William G, Findley, Harry W

“…Survivin is a novel member of the inhibitor of apoptosis protein (IAP) family. Here we report that the chemotherapeutic drug doxorubicin, a DNA-damaging agent,…”
Get more information

Contribution of STAT3 to the activation of survivin by GM-CSF in CD34+ cell lines by Gu, Lubing, Chiang, Kuang-Yueh, Zhu, Ningxi, Findley, Harry W, Zhou, Muxiang

“…Objective Granulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to specifically stimulate proliferation of CD34+ hematopoietic progenitor…”
Get full text

Tissue factor/FVIIa activates Bcl-2 and prevents doxorubicin-induced apoptosis in neuroblastoma cells by Fang, Jun, Gu, Lubing, Zhu, Ningxi, Tang, Hao, Alvarado, Carlos S, Zhou, Muxiang

“…Tissue factor (TF) is a transmembrane protein that acts as a receptor for activated coagulation factor VII (FVIIa), initiating the coagulation cascade. Recent…”
Get full text

Transcriptional repression of the eukaryotic initiation factor 4E gene by wild type p53 by Zhu, Ningxi, Gu, Lubing, Findley, Harry W., Zhou, Muxiang

“…The eukaryotic initiation factor 4E (eIF4E) plays important roles in transformation and cancer progression. It is frequently overexpressed in malignant cells,…”
Get full text

SAT-287 Association between serum homocysteine levels and advanced hepatic fibrosis in alcohol-related liver disease: a cross-sectional study by Yang, Hui, Ma, Cheng, Zhang, Xiaoqian, Zhang, Wenxin, Duan, Jianzhou, Gu, Lubing, Zhang, Wenhong

Get full text