Search Results - "Gu, Jijin"

Angiopep-conjugated poly(ethylene glycol)-co-poly(ϵ-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma by Xin, Hongliang, Jiang, Xinyi, Gu, Jijin, Sha, Xianyi, Chen, Liangcen, Law, Kitki, Chen, Yanzuo, Wang, Xiao, Jiang, Ye, Fang, Xiaoling

“…Abstract Dual-targeting nanoparticle drug delivery system was developed by conjugating Angiopep with PEG–PCL nanoparticles (ANG-NP) through bifunctional PEG to…”
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The brain targeting mechanism of Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles by Xin, Hongliang, Sha, Xianyi, Jiang, Xinyi, Chen, Liangcen, Law, Kitki, Gu, Jijin, Chen, Yanzuo, Wang, Xiao, Fang, Xiaoling

“…Abstract In order to evaluate the potential and mechanism of Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone)nanoparticles (ANG-PEG-NP) as…”
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Enhanced anti-glioblastoma efficacy by PTX-loaded PEGylated poly(ɛ-caprolactone) nanoparticles: In vitro and in vivo evaluation by Xin, Hongliang, Chen, Liangcen, Gu, Jijin, Ren, Xiaoqing, wei, Zhang, Luo, Jieqi, Chen, Yanzuo, Jiang, Xinyi, Sha, Xianyi, Fang, Xiaoling

“…The aim of this work was to investigate the anti-tumor effect of paclitaxel (PTX)-loaded methoxy poly(ethylene glycol)-poly(ɛ-caprolactone) nanoparticles…”
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Integrin-facilitated transcytosis for enhanced penetration of advanced gliomas by poly(trimethylene carbonate)-based nanoparticles encapsulating paclitaxel by Jiang, Xinyi, Sha, Xianyi, Xin, Hongliang, Xu, Ximing, Gu, Jijin, Xia, Weiyi, Chen, Shuo, Xie, Yike, Chen, Liangcen, Chen, Yanzuo, Fang, Xiaoling

“…Abstract The treatment of cerebral tumor, especially advanced gliomas, represents one of the most formidable challenges in oncology. In this study,…”
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Enhanced antitumor efficacy by d-glucosamine-functionalized and paclitaxel-loaded poly(ethylene glycol)-co-poly(trimethylene carbonate) polymer nanoparticles by Jiang, Xinyi, Xin, Hongliang, Gu, Jijin, Du, Fengyi, Feng, Chunlai, Xie, Yike, Fang, Xiaoling

“…The poor selectivity of chemotherapeutics for cancer treatment may lead to dose-limiting side effects that compromise clinical outcomes. To solve the problem,…”
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Protein/peptide-based entry/fusion inhibitors as anti-HIV therapies: challenges and future direction by Fumakia, Miral, Yang, Sidi, Gu, Jijin, Ho, Emmanuel A.

“…Summary The failures of several first‐generation and second‐generation small molecule drug‐based anti‐HIV therapies in various stages of clinical trials are an…”
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Enhanced anti-tumor effect of 9-nitro-camptothecin complexed by hydroxypropyl-β-cyclodextrin and safety evaluation by Jiang, Ye, Jiang, Xinyi, Law, Kitki, Chen, Yanzuo, Gu, Jijin, Zhang, Wei, Xin, Hongliang, Sha, Xianyi, Fang, Xiaoling

“…[Display omitted] ► We have developed a novel HP-β-CD-based formulation for the delivery of 9-NC. ► 9-NC complexedin HP-β-CD presented significant anti-tumor…”
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Nanoparticles of 2-deoxy- d -glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment by Jiang, Xinyi, Xin, Hongliang, Ren, Qiuyue, Gu, Jijin, Zhu, Lingjun, Du, Fengyi, Feng, Chunlai, Xie, Yike, Sha, Xianyi, Fang, Xiaoling

“…Abstract Based on the facilitative glucose transporter (GLUT) over-expression on both blood–brain barrier (BBB) and glioma cells, 2-deoxy- d -glucose modified…”
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Reversal of P-glycoprotein-mediated multidrug resistance by CD44 antibody-targeted nanocomplexes for short hairpin RNA-encoding plasmid DNA delivery by Gu, Jijin, Fang, Xiaoling, Hao, Junguo, Sha, Xianyi

“…Abstract Multidrug resistance (MDR) remains one of the major reasons for the reductions in efficacy of many chemotherapeutic agents in cancer therapy. As a…”
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Biodegradable Film for the Targeted Delivery of siRNA-Loaded Nanoparticles to Vaginal Immune Cells by Gu, Jijin, Yang, Sidi, Ho, Emmanuel A

“…The goal of this study was to develop and characterize a novel intravaginal film platform for targeted delivery of small interfering RNA (siRNA)-loaded…”
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pH-sensitive dual-preventive siRNA-based nanomicrobicide reactivates autophagy and inhibits HIV infection in vaginal CD4+ cells by Yang, Sidi, Chen, Yufei, Gu, Jijin, Harris, Angela, Su, Ruey-Chyi, Ho, Emmanuel A.

“…Women are more susceptible to HIV transmission through unprotected heterosexual intercourse due to biological and social vulnerabilities. Intravaginal delivery…”
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Retro-inverso d-peptide-modified hyaluronic acid/bioreducible hyperbranched poly(amido amine)/pDNA core-shell ternary nanoparticles for the dual-targeted delivery of short hairpin RNA-encoding plasmids by Gu, Jijin, Chen, Xinyi, Fang, Xiaoling, Sha, Xianyi

“…[Display omitted] The active targeting of gene carriers is a powerful strategy for improving tumour-specific delivery and therapy. Although numerous l-peptide…”
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Transdermal microemulsion drug delivery system for impairing male reproductive toxicity and enhancing efficacy of Tripterygium Wilfordii Hook f by Wang, Xiao, Xue, Mei, Gu, Jijin, Fang, Xiaoling, Sha, Xianyi

“…The present study is trying to produce a transdermal microemulsion drug delivery system (TMDDS) for Tripterygium Wilfordii Hook f. (TWHF) and attempting to…”
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Factors influencing the transfection efficiency and cellular uptake mechanisms of Pluronic P123-modified polypropyleneimine/pDNA polyplexes in multidrug resistant breast cancer cells by Gu, Jijin, Hao, Junguo, Fang, Xiaoling, Sha, Xianyi

“…[Display omitted] •The factors influencing the transfection efficiency of P123-PPI/pDNA polyplexes.•Effects of three kinds of inhibitors on the uptake and…”
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CD44-Targeted Hyaluronic Acid-Coated Redox-Responsive Hyperbranched Poly(amido amine)/Plasmid DNA Ternary Nanoassemblies for Efficient Gene Delivery by Gu, Jijin, Chen, Xinyi, Ren, Xiaoqing, Zhang, Xiulei, Fang, Xiaoling, Sha, Xianyi

“…Hyaluronic acid (HA), which can specifically bind to CD44 receptor, is a specific ligand for targeting to CD44-overexpressing cancer cells. The current study…”
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Enhanced antitumor efficacy by methotrexate conjugated Pluronic mixed micelles against KBv multidrug resistant cancer by Chen, Yanzuo, Zhang, Wei, Gu, Jijin, Ren, Qiuyue, Fan, Zhuoyang, Zhong, Weitong, Fang, Xiaoling, Sha, Xianyi

“…A methotrexate (MTX) conjugated polymeric mixed micelles for MDR cancer therapy was developed in this study. To the best of our knowledge, MTX was firstly…”
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Serum-resistant complex nanoparticles functionalized with imidazole-rich polypeptide for gene delivery to pulmonary metastatic melanoma by Gu, Jijin, Chen, Xinyi, Xin, Hongliang, Fang, Xiaoling, Sha, Xianyi

“…To enhance serum-resistance and overcome the lysosomal barrier are effective and feasible strategies to increase the transfection efficiency of non-viral gene…”
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Solid tumor penetration by integrin-mediated pegylated poly(trimethylene carbonate) nanoparticles loaded with paclitaxel by Jiang, Xinyi, Xin, Hongliang, Gu, Jijin, Xu, Ximing, Xia, Weiyi, Chen, Shuo, Xie, Yike, Chen, Liangcen, Chen, Yanzuo, Sha, Xianyi, Fang, Xiaoling

“…Abstract Limited penetration of antineoplastic agents is one of the contributing factors for chemotherapy failure of many solid tumors. In order to enhance…”
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Self-aggregated pegylated poly (trimethylene carbonate) nanoparticles decorated with c(RGDyK) peptide for targeted paclitaxel delivery to integrin-rich tumors by Jiang, Xinyi, Sha, Xianyi, Xin, Hongliang, Chen, Liangcen, Gao, Xihui, Wang, Xiao, Law, Kitki, Gu, Jijin, Chen, Yanzuo, Jiang, Ye, Ren, Xiaoqing, Ren, Qiuyue, Fang, Xiaoling

“…Abstract Cyclic RGD peptide-decorated polymeric micellar-like nanoparticles (MNP) based on PEGylated poly (trimethylene carbonate) (PEG-PTMC) were prepared for…”
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Self-assembled carboxymethyl poly ( l -histidine) coated poly (β-amino ester)/DNA complexes for gene transfection by Gu, Jijin, Wang, Xiao, Jiang, Xinyi, Chen, Yanzuo, Chen, Liangcen, Fang, Xiaoling, Sha, Xianyi

“…Abstract Biomaterials coated polymer/DNA complexes are developed as an efficient non-viral gene delivery system. It is able to circumvent the changes of…”
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