Search Results - "Gu, Guocan"
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Functionalized Macrophage Exosomes with Panobinostat and PPM1D‐siRNA for Diffuse Intrinsic Pontine Gliomas Therapy
Published in Advanced science (01-07-2022)“…Diffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain tumor. Mutation of p53‐induced protein phosphatase 1 (PPM1D) in DIPG cells promotes…”
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Clinical, pathological, and radiological features of 80 pediatric diffuse intrinsic pontine gliomas: A single-institute study
Published in Frontiers in oncology (07-02-2023)“…Diffuse intrinsic pontine gliomas (DIPGs) are rare but devastating diseases. This retrospective cross-sectional study aimed to investigate the clinical,…”
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Role of neuronavigation in the surgical management of brainstem gliomas
Published in Frontiers in oncology (02-05-2023)“…NeuroNavigation (NN) is a widely used intraoperative imaging guidance technique in neurosurgical operations; however, its value in brainstem glioma (BSG)…”
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White matter alterations in pediatric brainstem glioma: An national brain tumor registry of China study
Published in Frontiers in neuroscience (09-09-2022)“…Background Previous studies have identified alterations in structural connectivity of patients with glioma. However, white matter (WM) integrity measured by…”
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Diffusion MRI is valuable in brainstem glioma genotyping with quantitative measurements of white matter tracts
Published in European radiology (01-05-2024)“…Objectives To investigate the value of diffusion MRI (dMRI) in H3K27M genotyping of brainstem glioma (BSG). Methods A primary cohort of BSG patients with dMRI…”
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Adult diffuse intrinsic pontine glioma: clinical, radiological, pathological, molecular features, and treatments of 96 patients
Published in Journal of neurosurgery (01-12-2022)“…Unlike its pediatric counterpart, adult diffuse intrinsic pontine glioma (DIPG) remains largely unelucidated. In this study, the authors examined the clinical,…”
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Diffusion MRI-based connectomics features improve the noninvasive prediction of H3K27M mutation in brainstem gliomas
Published in Radiotherapy and oncology (01-09-2023)“…•Conventional MRI and dMRI provide different information in BSGs genotyping.•Machine learning-based models were built for noninvasive H3K27M mutation…”
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Brainstem tumors may increase the impairment of behavioral emotional cognition in children
Published in Journal of neuro-oncology (01-11-2022)“…Purpose It remains unclear as to whether patients with brainstem tumor experience complex neuropsychiatric problems. In this cohort study, we specifically…”
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Surgical management and clinical outcomes of cerebellar liponeurocytomas—a report of seven cases and a pooled analysis of individual patient data
Published in Neurosurgical review (01-04-2022)“…Cerebellar liponeurocytomas (CLPNs) are very rare, with very few studies on this disease. Their treatment protocol also remains unclear. To better understand…”
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Expression of Interleukin-13 Receptor Alpha 2 in Brainstem Gliomas
Published in Cancers (01-01-2024)“…The objective of this study was to investigate IL13Ra2 expression in brainstem glioma (BSG) and its correlation with key markers, functions, and prognostic…”
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A multimodal imaging-based classification for pediatric diffuse intrinsic pontine gliomas
Published in Neurosurgical review (26-06-2023)“…Object Pediatric diffuse intrinsic pontine glioma (DIPG) is a radiologically heterogeneous disease entity, here we aim to establish a multimodal imaging-based…”
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Classification of Brainstem Gliomas Based on Tumor Microenvironment Status
Published in Cancers (23-08-2023)“…The inter-tumor heterogeneity of the tumor microenvironment (TME) and how it correlates with clinical profiles and biological characteristics in brainstem…”
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