Search Results - "Gu, Frank X."

Iron oxide nanoparticles for targeted cancer imaging and diagnostics by Rosen, Joshua E, Chan, Lorena, Shieh, Dar-Bin, DDS, DMSc, Gu, Frank X., PhD

“…Abstract Superparamagnetic iron oxide nanoparticles (SPIONs) have proven to be highly effective contrast agents for the magnetic resonance imaging diagnosis of…”
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Materials for Sustained and Controlled Release of Nutrients and Molecules To Support Plant Growth by Davidson, Drew, Gu, Frank X

“…Controlled release fertilizers (CRFs) are a branch of materials that are designed to improve the soil release kinetics of chemical fertilizers to address…”
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Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles by Dhar, Shanta, Gu, Frank X, Langer, Robert, Farokhzad, Omid C, Lippard, Stephen J

“…Cisplatin is used to treat a variety of tumors, but dose limiting toxicities or intrinsic and acquired resistance limit its application in many types of cancer…”
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Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols by Chen, Paul Z, Bobrovitz, Niklas, Premji, Zahra, Koopmans, Marion, Fisman, David N, Gu, Frank X

“…Which virological factors mediate overdispersion in the transmissibility of emerging viruses remains a long-standing question in infectious disease…”
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Decontamination of N95 masks for re-use employing 7 widely available sterilization methods by Kumar, Anand, Kasloff, Samantha B, Leung, Anders, Cutts, Todd, Strong, James E, Hills, Kevin, Gu, Frank X, Chen, Paul, Vazquez-Grande, Gloria, Rush, Barret, Lother, Sylvain, Malo, Kimberly, Zarychanski, Ryan, Krishnan, Jay

“…The response to the COVID-19 epidemic is generating severe shortages of personal protective equipment around the world. In particular, the supply of N95…”
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Unsaturated Transport and Targeted Binding of Pluronic-Coated Nanoparticles: Lysimeter Experiments by Jaberi, Najmeh, Linley, Stuart, Thomson, Neil R., McVey, Kevin, Sra, Kanwartej, Gu, Frank X.

“…AbstractEfficient delivery of engineered nanoparticles (NPs) to a non-aqueous-phase liquid (NAPL) target zone located above the water table requires an…”
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SARS-CoV-2 shedding dynamics across the respiratory tract, sex, and disease severity for adult and pediatric COVID-19 by Chen, Paul Z, Bobrovitz, Niklas, Premji, Zahra A, Koopmans, Marion, Fisman, David N, Gu, Frank X

“…Previously, we conducted a systematic review and analyzed the respiratory kinetics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Chen et…”
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Sizing up feature descriptors for macromolecular machine learning with polymeric biomaterials by Stuart, Samantha, Watchorn, Jeffrey, Gu, Frank X.

“…It has proved challenging to represent the behavior of polymeric macromolecules as machine learning features for biomaterial interaction prediction. There are…”
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Nanomaterials for Ocular Drug Delivery by Liu, Shengyan, Jones, Lyndon, Gu, Frank X.

“…Efficient drug delivery to the eye remains a challenging task for pharmaceutical scientists. Due to the various anatomical barriers and the clearance…”
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Co-Delivery of Hydrophobic and Hydrophilic Drugs from Nanoparticle-Aptamer Bioconjugates by Zhang, Liangfang, Radovic-Moreno, Aleksandar F., Alexis, Frank, Gu, Frank X., Basto, Pamela A., Bagalkot, Vaishali, Jon, Sangyong, Langer, Robert S., Farokhzad, Omid C.

“…Herein we report a novel targeted drug delivery system consisting of nanoparticle–aptamer bioconjugates, which can carry both hydrophobic and hydrophilic…”
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Bridging the gap between in vitro and in vivo models: a way forward to clinical translation of mitochondrial transplantation in acute disease states by Bodenstein, David F, Siebiger, Gabriel, Zhao, Yimu, Clasky, Aaron J, Mukkala, Avinash N, Beroncal, Erika L, Banh, Lauren, Aslostovar, Lili, Brijbassi, Sonya, Hogan, Sarah E, McCully, James D, Mehrabian, Mohadeseh, Petersen, Thomas H, Robinson, Lisa A, Walker, Melanie, Zachos, Constantine, Viswanathan, Sowmya, Gu, Frank X, Rotstein, Ori D, Cypel, Marcelo, Radisic, Milica, Andreazza, Ana C

“…Mitochondrial transplantation and transfer are being explored as therapeutic options in acute and chronic diseases to restore cellular function in injured…”
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Development of Mucoadhesive Drug Delivery System Using Phenylboronic Acid Functionalized Poly(D,L-lactide)-b-Dextran Nanoparticles by Liu, Shengyan, Jones, Lyndon, Gu, Frank X.

“…Mucoadhesive NP drug carriers have attracted substantial interest as a potential treatment for anterior eye diseases. NPs composed of PLA‐Dex surface…”
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Surface Plasmon Resonance Biosensors Incorporating Gold Nanoparticles by Bedford, Erin E., Spadavecchia, Jolanda, Pradier, Claire-Marie, Gu, Frank X.

“…SPR biosensing is increasingly popular for the detection of a multitude of biomolecules. It offers label‐free detection and study of proteins, nucleic acids,…”
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Characterizing internal cavity modulation of corn starch microcapsules by Wulff, David, Chan, Ariel, Liu, Qiang, Gu, Frank X., Aucoin, Marc G.

“…Swelling of normal corn starch granules through heating in water leads to enlargement of the starch particles and a corresponding increase in internal cavity…”
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Tetanus toxin C fragment-conjugated nanoparticles for targeted drug delivery to neurons by Townsend, Seth A, Evrony, Gilad D, Gu, Frank X, Schulz, Martin P, Brown, Robert H, Langer, Robert

“…Abstract The use of nanoparticles for targeted drug delivery is often facilitated by specific conjugation of functional targeting molecules to the nanoparticle…”
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Colorimetric biosensing of pathogens using gold nanoparticles by Verma, Mohit S., Rogowski, Jacob L., Jones, Lyndon, Gu, Frank X.

“…Rapid detection of pathogens is crucial to minimize adverse health impacts of nosocomial, foodborne, and waterborne diseases. Gold nanoparticles are extremely…”
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Understanding why superspreading drives the COVID-19 pandemic but not the H1N1 pandemic by Chen, Paul Z, Koopmans, Marion, Fisman, David N, Gu, Frank X

“…Generally, k remains similar across distinct outbreaks of a virus.1 Studies have documented this for SARS-CoV-2, including across disparate geographical…”
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From prevention to diagnosis and treatment: Biomedical applications of metal nanoparticle-hydrogel composites by Clasky, Aaron J., Watchorn, Jeffrey D., Chen, Paul Z., Gu, Frank X.

“…Recent advances in biomaterials integrate metal nanoparticles with hydrogels to generate composite materials that exhibit new or improved properties. By…”
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Investigating the Molecular Mechanism of Protein-Polymer Binding with Direct Saturation Compensated Nuclear Magnetic Resonance by Watchorn, Jeffrey, Burns, Darcy, Stuart, Samantha, Gu, Frank X

“…Herein, we describe a new technique, direct saturation compensated transfer (DISCO) NMR, to characterize protein-macromolecule interactions. DISCO enables the…”
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Ion-Mediated Cross-Linking of Hyaluronic Acid into Hydrogels without Chemical Modification by Prakash, Gayatri, Clasky, Aaron J., Gadani, Kunal, Nazeri, Mohammad, Gu, Frank X.

“…Hyaluronic acid (HA) is a biomedically relevant polymer widely explored as a component of hydrogels. The prevailing approaches for cross-linking HA into…”
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