Lack of Antibody Production Following Immunization in Old Age: Association with CD8+CD28- T Cell Clonal Expansions and an Imbalance in the Production of Th1 and Th2 Cytokines

Lack of Antibody Production Following Immunization in Old Age: Association with CD8+CD28- T Cell Clonal Expansions and an Imbalance in the Production of Th1 and Th2 Cytokines

Although it is generally recognized that the function of the immune system declines with age, the nature of the underlying defects is still poorly understood. We now demonstrate the predominance of CD8(+)CD28(-) T cell clonal expansions in elderly persons who fail to produce specific Abs following i...

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Bibliographic Details
Published in:The Journal of immunology (1950) Vol. 168; no. 11; pp. 5893 - 5899
Main Authors: Saurwein-Teissl, Maria, Lung, Thomas L, Marx, Florentine, Gschosser, Claudio, Asch, Esther, Blasko, Imrich, Parson, Walther, Bock, Gunther, Schonitzer, Diether, Trannoy, Emanuelle, Grubeck-Loebenstein, Beatrix
Format: Journal Article
Language:English
Published: United States Am Assoc Immnol 01-06-2002
Subjects:
Aged
Aged, 80 and over
Aging - immunology
Antibodies, Viral - blood
CD28 Antigens - analysis
CD8 Antigens - analysis
Cytokines - biosynthesis
Female
Humans
Influenza Vaccines - immunology
Male
Middle Aged
T-Lymphocyte Subsets - immunology
Th1 Cells - immunology
Th2 Cells - immunology
Vaccination
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Summary:Although it is generally recognized that the function of the immune system declines with age, the nature of the underlying defects is still poorly understood. We now demonstrate the predominance of CD8(+)CD28(-) T cell clonal expansions in elderly persons who fail to produce specific Abs following influenza vaccination. These clones express effector cell markers and are mostly CD45RA(+). When isolated and put into culture, they are unable to proliferate, but produce IFN-gamma (but no IL-5) upon stimulation with anti-CD3 or autoantigen. These autoreactive CD8(+) type 1 effector cells seem to trigger a Th1 polarization, as CD4(+) T cells from elderly persons without in vivo Ab production produce Th1, but only low amounts of Th2 cytokines upon in vitro stimulation with PHA. Therefore, the increased occurrence of CD8(+)CD28(-) clonal expansions may be decisive for the development of immune deficiency in the elderly.
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ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.168.11.5893