Search Results - "Grzymski, Joseph J"

Genome-wide rare variant analysis for thousands of phenotypes in over 70,000 exomes from two cohorts by Cirulli, Elizabeth T., White, Simon, Read, Robert W., Elhanan, Gai, Metcalf, William J., Tanudjaja, Francisco, Fath, Donna M., Sandoval, Efren, Isaksson, Magnus, Schlauch, Karen A., Grzymski, Joseph J., Lu, James T., Washington, Nicole L.

“…Understanding the impact of rare variants is essential to understanding human health. We analyze rare (MAF < 0.1%) variants against 4264 phenotypes in 49,960…”
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The significance of nitrogen cost minimization in proteomes of marine microorganisms by Grzymski, Joseph J, Dussaq, Alex M

“…Marine microorganisms thrive under low levels of nitrogen (N). N cost minimization is a major selective pressure imprinted on open-ocean microorganism genomes…”
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Clinical case study meets population cohort: identification of a BRCA1 pathogenic founder variant in Orcadians by Kerr, Shona M, Cowan, Emma, Klaric, Lucija, Bell, Christine, O'Sullivan, Dawn, Buchanan, David, Grzymski, Joseph J, van Hout, Cristopher V, Tzoneva, Gannie, Shuldiner, Alan R, Wilson, James F, Miedzybrodzka, Zosia

“…We multiply ascertained the BRCA1 pathogenic missense variant c.5207T > C; p.Val1736Ala (V1736A) in clinical investigation of breast and ovarian cancer…”
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The Impact of ACEs on BMI: An Investigation of the Genotype-Environment Effects of BMI by Schlauch, Karen A, Read, Robert W, Neveux, Iva, Lipp, Bruce, Slonim, Anthony, Grzymski, Joseph J

“…Adverse Childhood Experiences are stressful and traumatic events occurring before the age of eighteen shown to cause mental and physical health problems,…”
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Diversity and genomics of Antarctic marine micro-organisms by Murray, Alison E, Grzymski, Joseph J

“…Marine bacterioplanktons are thought to play a vital role in Southern Ocean ecology and ecosystem function, as they do in other ocean systems. However, our…”
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GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort by Read, Robert W, Schlauch, Karen A, Elhanan, Gai, Metcalf, William J, Slonim, Anthony D, Aweti, Ramsey, Borkowski, Robert, Grzymski, Joseph J

“…In this study, we perform a full genome-wide association study (GWAS) to identify statistically significantly associated single nucleotide polymorphisms (SNPs)…”
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HLA-A∗03:01 is associated with increased risk of fever, chills, and stronger side effects from Pfizer-BioNTech COVID-19 vaccination by Bolze, Alexandre, Neveux, Iva, Schiabor Barrett, Kelly M., White, Simon, Isaksson, Magnus, Dabe, Shaun, Lee, William, Grzymski, Joseph J., Washington, Nicole L., Cirulli, Elizabeth T.

“…COVID-19 vaccines are safe and highly effective, but some individuals experience unpleasant reactions to vaccination. As the majority of adults in the United…”
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Using phenome-wide association studies and the SF-12 quality of life metric to identify profound consequences of adverse childhood experiences on adult mental and physical health in a Northern Nevadan population by Schlauch, Karen A., Read, Robert W., Koning, Stephanie M., Neveux, Iva, Grzymski, Joseph J.

“…In this research, we examine and identify the implications of Adverse Childhood Experiences (ACEs) on a range of health outcomes, with particular focus on a…”
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A Comprehensive Genome-Wide and Phenome-Wide Examination of BMI and Obesity in a Northern Nevadan Cohort by Schlauch, Karen A, Read, Robert W, Lombardi, Vincent C, Elhanan, Gai, Metcalf, William J, Slonim, Anthony D, Grzymski, Joseph J

“…The aggregation of Electronic Health Records (EHR) and personalized genetics leads to powerful discoveries relevant to population health. Here we perform…”
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The common oceanographer: crowdsourcing the collection of oceanographic data by Lauro, Federico M, Senstius, Svend Jacob, Cullen, Jay, Neches, Russell, Jensen, Rachelle M, Brown, Mark V, Darling, Aaron E, Givskov, Michael, McDougald, Diane, Hoeke, Ron, Ostrowski, Martin, Philip, Gayle K, Paulsen, Ian T, Grzymski, Joseph J

“…  Funding: The authors acknowledge financial support from the School of BABS (University of New South Wales), the ithree Institute (University of Technology…”
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Incomplete Penetrance of Population-Based Genetic Screening Results in Electronic Health Record by Elhanan, Gai, Kiser, Daniel, Neveux, Iva, Dabe, Shaun, Bolze, Alexandre, Metcalf, William J, Lu, James T, Grzymski, Joseph J

“…The clinical value of population-based genetic screening projects depends on the actions taken on the findings. The Healthy Nevada Project (HNP) is an…”
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Genome Sequence of Psychrobacter arcticus 273-4, a Psychroactive Siberian Permafrost Bacterium, Reveals Mechanisms for Adaptation to Low-Temperature Growth by Ayala-del-Río, Héctor L, Chain, Patrick S, Grzymski, Joseph J, Ponder, Monica A, Ivanova, Natalia, Bergholz, Peter W, Di Bartolo, Genevive, Hauser, Loren, Land, Miriam, Bakermans, Corien, Rodrigues, Debora, Klappenbach, Joel, Zarka, Dan, Larimer, Frank, Richardson, Paul, Murray, Alison, Thomashow, Michael, Tiedje, James M

“…Psychrobacter arcticus strain 273-4, which grows at temperatures as low as -10°C, is the first cold-adapted bacterium from a terrestrial environment whose…”
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Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population by Read, Robert W, Schlauch, Karen A, Lombardi, Vincent C, Cirulli, Elizabeth T, Washington, Nicole L, Lu, James T, Grzymski, Joseph J

“…Clinical conditions correlated with elevated triglyceride levels are well-known: coronary heart disease, hypertension, and diabetes. Underlying genetic and…”
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Resource Concentration Modulates the Fate of Dissimilated Nitrogen in a Dual-Pathway Actinobacterium by Vuono, David C, Read, Robert W, Hemp, James, Sullivan, Benjamin W, Arnone, 3rd, John A, Neveux, Iva, Blank, Robert R, Loney, Evan, Miceli, David, Winkler, Mari-Karoliina H, Chakraborty, Romy, Stahl, David A, Grzymski, Joseph J

“…Respiratory ammonification and denitrification are two evolutionarily unrelated dissimilatory nitrogen (N) processes central to the global N cycle, the…”
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A power-based sliding window approach to evaluate the clinical impact of rare genetic variants in the nucleotide sequence or the spatial position of the folded protein by Cirulli, Elizabeth T., Schiabor Barrett, Kelly M., Bolze, Alexandre, Judge, Daniel P., Pawloski, Pamala A., Grzymski, Joseph J., Lee, William, Washington, Nicole L.

“…Systematic determination of novel variant pathogenicity remains a major challenge, even when there is an established association between a gene and phenotype…”
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A Real-Time Multiplexed Microbial Growth Intervalometer for Capturing High-Resolution Growth Curves by Vuono, David C, Lipp, Bruce, Staub, Carl, Loney, Evan, Harrold, Zoë R, Grzymski, Joseph J

“…Batch cultures are a low maintenance and routine culturing method in microbiology. Automated tools that measure growth curves from microorganisms grown in…”
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Metagenome analysis of an extreme microbial symbiosis reveals eurythermal adaptation and metabolic flexibility by Grzymski, Joseph J, Murray, Alison E, Campbell, Barbara J, Kaplarevic, Mihailo, Gao, Guang R, Lee, Charles, Daniel, Roy, Ghadiri, Amir, Feldman, Robert A, Cary, Stephen C

“…Hydrothermal vent ecosystems support diverse life forms, many of which rely on symbiotic associations to perform functions integral to survival in these…”
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Protein languages differ depending on microorganism lifestyle by Grzymski, Joseph J, Marsh, Adam G

“…Few quantitative measures of genome architecture or organization exist to support assumptions of differences between microorganisms that are broadly defined as…”
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Microbial biodiversity of thermophilic communities in hot mineral soils of Tramway Ridge, Mount Erebus, Antarctica by Soo, Rochelle M, Wood, Susanna A, Grzymski, Joseph J, McDonald, Ian R, Cary, S. Craig

“…Tramway Ridge, located near the summit of Mount Erebus in Antarctica, is probably the most remote geothermal soil habitat on Earth. Steam fumaroles maintain…”
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The Anti-Oxidant Defense System of the Marine Polar Ciliate Euplotes nobilii: Characterization of the MsrB Gene Family by Ricci, Francesca, Lauro, Federico M, Grzymski, Joseph J, Read, Robert, Bakiu, Rigers, Santovito, Gianfranco, Luporini, Pierangelo, Vallesi, Adriana

“…Organisms living in polar waters must cope with an extremely stressful environment dominated by freezing temperatures, high oxygen concentrations and UV…”
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