Search Results - "Grzelak, M."

Strategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screening by Grzelak, Edyta M., Choules, Mary P., Gao, Wei, Cai, Geping, Wan, Baojie, Wang, Yuehong, McAlpine, James B., Cheng, Jinhua, Jin, Yingyu, Lee, Hanki, Suh, Joo-Won, Pauli, Guido F., Franzblau, Scott G., Jaki, Birgit U., Cho, Sanghyun

“…The rise of multi- and extensively drug-resistant Mycobacterium tuberculosis ( M. tb ) strains and co-infection with human immunodeficiency virus has escalated…”
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Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2 by Bulos, Maya L, Grzelak, Edyta M, Li-Ma, Chloris, Chen, Emily, Hull, Mitchell, Johnson, Kristen A, Bollong, Michael J

“…Yes-associated protein (YAP), the downstream effector of the evolutionarily conserved Hippo pathway, promotes cellular proliferation and coordinates certain…”
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Diagnosis of ovarian tumour tissues by SR-FTIR spectroscopy: A pilot study by Grzelak, M.M., Wróbel, P.M., Lankosz, M., Stęgowski, Z., Chmura, Ł., Adamek, D., Hesse, B., Castillo-Michel, H.

“…Ovarian cancer is the seventh most common cancer among women across the world with very high mortality rates. Histology is considered the gold standard for…”
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Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy by Mikula, M, Skrzypczak, M, Goryca, K, Paczkowska, K, Ledwon, J K, Statkiewicz, M, Kulecka, M, Grzelak, M, Dabrowska, M, Kuklinska, U, Karczmarski, J, Rumienczyk, I, Jastrzebski, K, Miaczynska, M, Ginalski, K, Bomsztyk, K, Ostrowski, J

“…Genome-wide mechanisms that coordinate expression of subsets of functionally related genes are largely unknown. Recent studies show that receptor tyrosine…”
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The impact of research and development activity on the TFP level in manufacturing in Poland by Elżbieta Roszko-Wójtowicz, Maria M. Grzelak, Iwona Laskowska

“…Research background: The paper presents the issue of total factor productivity in the manufacturing industry in Poland. It has been assumed that total factor…”
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Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species by VARTY, G. B, HYDE, L. A, XU, X, KORFMACHER, W. A, TULSHIAN, D, PARKER, E. M, HIGGINS, G. A, HODGSON, R. A, LU, S. X, MCCOOL, M. F, KAZDOBA, T. M, DEL VECCHIO, R. A, GUTHRIE, D. H, POND, A. J, GRZELAK, M. E

“…Previous studies have demonstrated behaviors indicative of anxiolysis in rats pretreated with the nociceptin receptor (opioid receptor like-1, ORL-1) agonist,…”
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Application of the total reflection X-ray fluorescence method to the elemental analysis of brain tumors of different types and grades of malignancy by Lankosz, M.W., Grzelak, M., Ostachowicz, B., Wandzilak, A., Szczerbowska-Boruchowska, M., Wrobel, P., Radwanska, E., Adamek, D.

“…The process of carcinogenesis may influence normal biochemical reactions leading to alterations in the elemental composition of the tissue. Total reflection…”
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Bioautography detection in thin-layer chromatography by Choma, Irena M., Grzelak, Edyta M.

“…Bioautography is a microbial detection method hyphenated with planar chromatography techniques. It is based mainly on antimicrobial or antifungal properties of…”
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Comparison of deproteinization methods used before TLC-DB and HPLC analysis of flumequine residues in milk by Choma, Irena M, Grzelak, Edyta M, Majer-Dziedzic, Barbara

“…Seventeen various extraction procedures based on precipitation of proteins in milk samples spiked with flumequine were tested. Several criteria were taken into…”
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T.P.10 The acute effects of curcumin exposure on skeletal muscle contractile function by Pinniger, G.J, Grzelak, M, Zhang, B, Bakker, A.J

“…Abstract Curcumin is a component in the Asian spice turmeric which has demonstrated anti-inflammatory, anti-oxidant and anti-cancer effects in animal models of…”
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QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity by Gomes, Marcelo N., Braga, Rodolpho C., Grzelak, Edyta M., Neves, Bruno J., Muratov, Eugene, Ma, Rui, Klein, Larry L., Cho, Sanghyun, Oliveira, Guilherme R., Franzblau, Scott G., Andrade, Carolina Horta

“…New anti-tuberculosis (anti-TB) drugs are urgently needed to battle drug-resistant Mycobacterium tuberculosis strains and to shorten the current 6–12-month…”
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Macroeconomic stability and the level of competitiveness in EU member states: a comparative dynamic approach by Roszko-Wójtowicz, Elżbieta, Grzelak, Maria M.

“…Research background: The choice of the issue of international competitive-ness of economies as the research problem addressed in this paper has been mainly…”
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Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus by Choules, Mary P, Wolf, Nina M, Lee, Hyun, Anderson, Jeffrey R, Grzelak, Edyta M, Wang, Yuehong, Ma, Rui, Gao, Wei, McAlpine, James B, Jin, Ying-Yu, Cheng, Jinhua, Lee, Hanki, Suh, Joo-Won, Duc, Nguyen Minh, Paik, Seungwha, Choe, Jin Ho, Jo, Eun-Kyeong, Chang, Chulhun L, Lee, Jong Seok, Jaki, Birgit U, Pauli, Guido F, Franzblau, Scott G, Cho, Sanghyun

“…ClpC1 is an emerging new target for the treatment of infections, and several cyclic peptides (ecumicin, cyclomarin A, and lassomycin) are known to act on this…”
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Rv0100: An essential acyl carrier protein from M. tuberculosis important in dormancy by Gutka, Hiten J, Bondoc, Jasper Marc G, Patwell, Ryan, Khan, Shahebraj, Grzelak, Edyta M, Goswami, Rajendra, Voskuil, Martin I, Movahedzadeh, Farahnaz

“…We have identified an acyl-carrier protein, Rv0100, that is up-regulated in a dormancy model. This protein plays a critical role in the fatty acid biosynthesis…”
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Pharmacological YAP activation promotes regenerative repair of cutaneous wounds by Grzelak, Edyta M, Elshan, N G R Dayan, Shao, Sida, Bulos, Maya L, Joseph, Sean B, Chatterjee, Arnab K, Chen, Jian Jeffrey, Nguyên-Trân, Vân, Schultz, Peter G, Bollong, Michael J

“…Chronic cutaneous wounds remain a persistent unmet medical need that decreases life expectancy and quality of life. Here, we report that topical application of…”
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Nanoscale Limit to the Applicability of Wenzel’s Equation by Grzelak, Eric M, Errington, Jeffrey R

“…We examine the extent to which nanoscale geometric substrate roughness influences the contact angle droplets establish on solid surfaces. Free-energy-based…”
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YAP-dependent proliferation by a small molecule targeting annexin A2 by Shalhout, Sophia Z., Yang, Peng-Yu, Grzelak, Edyta M., Nutsch, Kayla, Shao, Sida, Zambaldo, Claudio, Iaconelli, Jonathan, Ibrahim, Lara, Stanton, Caroline, Chadwick, Stormi R., Chen, Emily, DeRan, Michael, Li, Sijia, Hull, Mitchell, Wu, Xu, Chatterjee, Arnab K., Shen, Weijun, Camargo, Fernando D., Schultz, Peter G., Bollong, Michael J.

“…The transcriptional coactivator Yes-associated protein 1 (YAP) orchestrates a proproliferative transcriptional program that controls the fate of somatic stem…”
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Sweet spot matching: A thin-layer chromatography-based countercurrent solvent system selection strategy by Liu, Yang, Friesen, J. Brent, Grzelak, Edyta M., Fan, Qingfei, Tang, Ting, Durić, Kemal, Jaki, Birgit U., McAlpine, James B., Franzblau, Scott G., Chen, Shao-Nong, Pauli, Guido F.

“…•TLC method of solvent system selection for countercurrent separation is revisited.•A broader approach to the GUESS method is implemented.•The theory…”
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In search of key determinants of innovativeness in the regions of the Visegrad group countries by Roszko-Wójtowicz, Elżbieta, Dańska-Borsiak, Barbara, Grzelak, Maria M., Pleśniarska, Aleksandra

“…Research background: Discussions on the state of the economy in times of crisis focus not only on maintaining or improving innovativeness, but also on the…”
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Deep Convolutional Network for Steganalysis of HUGO, WOW, and UNIWARD algorithms by Lichy, K., Lipinski, P., Grzelak, M.

“…This paper presents a novel convolutional neural network (CNN) architecture for image steganalysis. We trained the CNN to detect distortions introduced by the…”
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