Search Results - "Grzela, Dawid P"
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Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates
Published in Nature genetics (01-06-2009)“…Zsuzsanna Izsvák and colleagues report the generation of a hyperactive version of the Sleeping Beauty transposase that supports efficient and stable gene…”
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Characterization of an induced pluripotent stem cell line (IMBPASi001-A) derived from fibroblasts of a patient affected by Wolfram Syndrome
Published in Stem cell research (01-07-2020)“…Wolfram Syndrome is a rare, autosomal recessive genetic disorder with clinical symptoms appearing in early childhood. Here, we report a generation of iPSCs…”
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Generation of human iPSCs from cells of fibroblastic and epithelial origin by means of the oriP/EBNA-1 episomal reprogramming system
Published in Stem cell research & therapy (19-06-2015)“…The prospect of therapeutic applications of the induced pluripotent stem cells (iPSCs) is based on their ability to generate virtually any cell type present in…”
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4
EGFR Activation Leads to Cell Death Independent of PI3K/AKT/mTOR in an AD293 Cell Line
Published in PloS one (06-05-2016)“…The Epidermal Growth Factor Receptor (EGFR) and its mutations contribute in various ways to tumorigenesis and biology of human cancers. They are associated…”
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SOX2 and SOX2-MYC Reprogramming Process of Fibroblasts to the Neural Stem Cells Compromised by Senescence
Published in PloS one (04-11-2015)“…Tumorigenic potential of induced pluripotent stem cells (iPSCs) infiltrating population of induced neural stem cells (iNSCs) generated from iPSCs may limit…”
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Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes
Published in Proceedings of the National Academy of Sciences - PNAS (25-03-2008)“…Ancient, inactive copies of transposable elements of the PIF/Harbinger superfamily have been described in vertebrates. We reconstructed components of the…”
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Novel strong tissue specific promoter for gene expression in human germ cells
Published in BMC biotechnology (17-08-2010)“…Tissue specific promoters may be utilized for a variety of applications, including programmed gene expression in cell types, tissues and organs of interest,…”
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Directed differentiation of human iPSC into insulin producing cells is improved by induced expression of PDX1 and NKX6.1 factors in IPC progenitors
Published in Journal of translational medicine (20-12-2016)“…Induced pluripotent stem cells (iPSC) possess an enormous potential as both, scientific and therapeutic tools. Their application in the regenerative medicine…”
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SOX2 and SOX2-MYC Reprogramming Process of Fibroblasts to the Neural Stem Cells Compromised by Senescence: e0141688
Published in PloS one (01-11-2015)“…Tumorigenic potential of induced pluripotent stem cells (iPSCs) infiltrating population of induced neural stem cells (iNSCs) generated from iPSCs may limit…”
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