Lack of Cyathostomin sp. reduction after anthelmintic treatment in horses in Brazil

Lack of Cyathostomin sp. reduction after anthelmintic treatment in horses in Brazil

The increase of anthelmintic resistance in the last years in the nematode population of veterinary importance has become a major concern. The objective of the present study was to evaluate the efficacy of the main anthelmintic drugs available in the market against small strongyles of horses in Brazi...

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Bibliographic Details
Published in:Veterinary parasitology Vol. 194; no. 1; pp. 35 - 39
Main Authors: Canever, Ricardo J., Braga, Pollyana R.C., Boeckh, Albert, Grycajuck, Marcelly, Bier, Daniele, Molento, Marcelo B.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-05-2013
Subjects:
Animals
Anthelmintic resistance
Antinematodal Agents - pharmacology
Antinematodal Agents - therapeutic use
Brazil
Cyathostominae
Drug Resistance
Drug Resistance, Multiple
Drugs
Efficacy
farms
fecal egg count
Feces - parasitology
Female
fenbendazole
Fenbendazole - pharmacology
Fenbendazole - therapeutic use
Horses
Indexing in process
ivermectin
Macrolides - pharmacology
Macrolides - therapeutic use
Male
moxidectin
multiple drug resistance
Parasite Egg Count - veterinary
Prevalence
pyrantel
Pyrantel - pharmacology
Pyrantel - therapeutic use
Small strongyles
Strongyle Infections, Equine - drug therapy
Strongyle Infections, Equine - parasitology
Strongyloidea - drug effects
Strongyloidea - physiology
Brazil
Drugs
Horses
Anthelmintic resistance
Efficacy
Small strongyles
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Summary:The increase of anthelmintic resistance in the last years in the nematode population of veterinary importance has become a major concern. The objective of the present study was to evaluate the efficacy of the main anthelmintic drugs available in the market against small strongyles of horses in Brazil. A total of 498 horses from 11 horse farms, located in the states of Paraná, São Paulo, Rio de Janeiro and Minas Gerais, in Brazil, were treated with ivermectin, moxidectin, pyrantel and fenbendazole, orally at their recommended doses. The fecal egg count reduction test (FECRT) was used to determine the product's efficacy and fecal culture was used to determine the parasite genus. Reduction on anthelmintic efficacy was found for fenbendazole in all horse farms (11/11), pyrantel in five yards (5/11) and ivermectin had low efficacy in one of the yards studied (1/11). Multidrug resistance of up to 3 drugs classes was found in one of the tested farms (1/11). Cyathostomin were the most prevalent parasite. The results showed that resistance to fenbendazole is widespread; the efficacy of pyrantel is in a critical situation. Although the macrocyclic lactones compounds still showed high efficacy on most farms, suspected resistance to macrocyclic lactones is of great concern.
Bibliography:http://dx.doi.org/10.1016/j.vetpar.2012.12.020
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ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2012.12.020