Search Results - "Gruys, M E"

Constitutive expression of functional CD40 on mouse renal cancer cells: Induction of Fas and Fas-mediated killing by CD40L by Lee, J.-K., Seki, N., Sayers, T.J., Subleski, J., Gruys, E.M., Murphy, W.J., Wiltrout, R.H.

“…CD40, a member of the TNF receptor superfamily, is expressed on B cells, dendritic cells, and some tumor cells, including melanoma and bladder carcinoma. In…”
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Complete Regression of Established Spontaneous Mammary Carcinoma and the Therapeutic Prevention of Genetically Programmed Neoplastic Transition by IL-12/Pulse IL-2: Induction of Local T Cell Infiltration, Fas/Fas Ligand Gene Expression, and Mammary Epithelial Apoptosis by Wigginton, Jon M, Park, Jong-Wook, Gruys, M. Eilene, Young, Howard A, Jorcyk, Cheryl L, Back, Timothy C, Brunda, Michael J, Strieter, Robert M, Ward, Jerrold, Green, Jeffrey E, Wiltrout, Robert H

“…Using a novel transgenic mouse model of spontaneous mammary carcinoma, we show here that the IL-12/pulse IL-2 combination can induce rapid and complete…”
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Primary hepatocytes from mice treated with IL-2/IL-12 produce T cell chemoattractant activity that is dependent on monokine induced by IFN-gamma (Mig) and chemokine responsive to gamma-2 (Crg-2) by Park, J W, Gruys, M E, McCormick, K, Lee, J K, Subleski, J, Wigginton, J M, Fenton, R G, Wang, J M, Wiltrout, R H

“…The IFN-gamma-inducible proteins monokine induced by IFN-gamma (Mig) and chemokine responsive to gamma-2 (Crg-2) can contribute to IL-12-induced antiangiogenic…”
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Flavone acetic acid directly induces expression of cytokine genes in mouse splenic leukocytes but not in human peripheral blood leukocytes by FUTAMI, H, EADER, L. A, KOMSCHLIES, K. L, BULL, R, GRUYS, M. E, ORTALDO, J. R, YOUNG, H. A, WILTROUT, R. H

“…Flavone-8-acetic acid (FAA) is a flavonoid drug that augments mouse natural killer activity, induces cytokine gene expression, and synergizes with recombinant…”
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Augmentation of mouse liver-associated natural killer activity by biologic response modifiers occurs largely via rapid recruitment of large granular lymphocytes from the bone marrow by Wiltrout, RH, Pilaro, AM, Gruys, ME, Talmadge, JE, Longo, DL, Ortaldo, JR, Reynolds, CW

“…A variety of biologic response modifiers (BRM) can potently augment NK activity in nonlymphoid organs. By using the liver as a model organ, we have shown that…”
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Induction of transplantable mouse renal cell cancers by streptozotocin : In vivo growth, metastases, and angiogenic phenotype by GRUYS, M. Eilene, BACK, Timothy C, WILTROUT, Robert H, SUBLESKI, Jeff, WILTROUT, Theresa A, LEE, Jong-Keuk, SCHMIDT, Laura, WATANABE, Morihiro, STANYON, Roscoe, WARD, Jerrold M, WIGGINTON, Jon M

“…Interleukin-2-based regimens of biological therapy have shown some clinical promise for the treatment of kidney cancer in humans, although the mechanisms…”
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Administration of recombinant human IL-7 to mice alters the composition of B-lineage cells and T cell subsets, enhances T cell function, and induces regression of established metastases by Komschlies, KL, Gregorio, TA, Gruys, ME, Back, TC, Faltynek, CR, Wiltrout, RH

“…These studies investigate the effects of exogenously administered recombinant human IL-7 (rhIL-7) on mouse leukocyte subsets in vivo in normal and…”
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Effects of rhIL-7 on leukocyte subsets in mice: implications for antitumor activity by Komschlies, K L, Back, T T, Gregorio, T A, Gruys, M E, Damia, G, Wiltrout, R H, Faltynek, C R

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In vivo distribution and cytokine gene expression by enriched mouse LAK effector cells by FUTAMI, H, PILARO, A. M, GRUYS, M. E, BACK, T. C, YOUNG, H. A, WILTROUT, R. H

“…Lymphokine activated killer (LAK) cells administered in combination with interleukin 2 (IL2) can mediate antitumor activity in tumor-bearing mice and advanced…”
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Prevention of acute chemotherapy-induced death in mice by recombinant human interleukin 1 : protection from hematological and nonhematological toxicities by DAMIA, G, KOMSCHLIES, K. L, FUTAMI, H, BACK, T, EILENE GRUYS, M, LONGO, D. L, KELLER, J. R, RUSCETTI, F. W, WILTROUT, R. H

“…Previous studies have demonstrated that interleukin 1 (IL-1) can protect most mice from the acute lethal toxicity mediated by high doses of radiation and/or…”
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