Search Results - "Gruskin, Elliott"

Strategies for Derisking Translational Processes for Biomedical Technologies by Abou-El-Enein, Mohamed, Duda, Georg N, Gruskin, Elliott A, Grainger, David W

“…Inefficient translational processes for technology-oriented biomedical research have led to some prominent and frequent failures in the development of many…”
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Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord by Caggiano, Anthony O, Zimber, Michael P, Ganguly, Anindita, Blight, Andrew R, Gruskin, Elliott A

“…Chondroitin sulfate proteoglycans are synthesized and deposited in the spinal cord following injury. These proteoglycans may restrict regeneration and…”
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Co-translational incorporation of trans-4-hydroxyproline into recombinant proteins in bacteria by Buechter, Douglas D, Paolella, David N, Leslie, Bridget S, Brown, Melissa S, Mehos, Karen A, Gruskin, Elliott A

“…Trans-4-hydroxyproline (Hyp) in eukaryotic proteins arises from post-translational modification of proline residues. Because the modification enzyme is not…”
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Evaluation of a Fiber Reinforced Drillable Bone Cement for Screw Augmentation in a Sheep Model-Mechanical Testing by Ahern, Benjamin J., Harten, Robert D., Gruskin, Elliott A., Schaer, Thomas P.

“…We evaluated the mechanical properties of a novel fiber reinforced calcium phosphate at time zero and after 12 weeks in vivo using a sheep long bone osteotomy…”
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Demineralized bone matrix in bone repair: History and use by Gruskin, Elliott, Doll, Bruce A., Futrell, F. William, Schmitz, John P., Hollinger, Jeffrey O.

“…Demineralized bone matrix (DBM) is an osteoconductive and osteoinductive commercial biomaterial and approved medical device used in bone defects with a long…”
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Increase in wound breaking strength in rats in the presence of positively charged dextran beads correlates with an increase in endogenous transforming growth factor-β1 and its receptor TGF-βRI in close proximity to the wound by Connors, David, Gies, David, Lin, Herrick, Gruskin, Elliott, Mustoe, Thomas A, Tawil, Nabil J

“…We have previously shown that positively charged beads (DEAE A25) increase wound breaking strength in linear incisions in rats and nonhuman primates at days…”
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Transforming Growth Factor-β1 Fails to Stimulate Wound Healing and Impairs Its Signal Transduction in an Aged Ischemic Ulcer Model by Wu, Liancun, Xia, Yu-Ping, Roth, Sanford I., Gruskin, Elliott, Mustoe, Thomas A.

“…Clinical trials of exogenous growth factors in treating chronic wounds have been less successful than expected. One possible explanation is that most studies…”
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Changing the mindset in life sciences toward translation: a consensus by Duda, Georg N, Grainger, David W, Frisk, Megan L, Bruckner-Tuderman, Leena, Carr, Andrew, Dirnagl, Ulrich, Einhäupl, Karl Max, Gottschalk, Stephen, Gruskin, Elliott, Huber, Christoph, June, Carl H, Mooney, David J, Rietschel, Ernst Th, Schütte, Georg, Seeger, Werner, Stevens, Molly M, Urban, Robert, Veldman, Alex, Wess, Günther, Volk, Hans-Dieter

“…Participants at the recent Translate! 2014 meeting in Berlin, Germany, reached a consensus on the rate-limiting factor for advancing translational medicine…”
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Stimulation of wound healing by positively charged dextran beads depends upon clustering of beads and cells in close proximity to the wound by Tawil, Nabil J, Connors, David, Gies, David, Bennett, Steven, Gruskin, Elliott, Mustoe, Thomas

“…We have previously shown that positively charged dextran (DEAE A25) increases wound breaking strength in linear incisions in rats and nonhuman primates at days…”
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Co-translational Incorporation ofTrans-4-Hydroxyproline into Recombinant Proteins in Bacteria by Buechter, Douglas D., Paolella, David N., Leslie, Bridget S., Brown, Melissa S., Mehos, Karen A., Gruskin, Elliott A.

“…Trans-4-hydroxyproline (Hyp) in eukaryotic proteins arises from post-translational modification of proline residues. Because the modification enzyme is not…”
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B-DNA to Z-DNA structural transitions in the SV40 enhancer: Stabilization of Z-DNA in negatively supercoiled DNA minicircles by Gruskin, Elliott A, Rich, Alexander

“…During replication and transcription, the SV40 control region is subjected to significant levels of DNA unwinding. There are three, alternating…”
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Demineralized bone matrix in bone repair: History and use: TARGETED DELIVERY OF THERAPEUTICS TO BONE AND CONNECTIVE TISSUES by GRUSKIN, Elliott, DOLL, Bruce A, FUTRELL, F. William, SCHMITZ, John P, HOLLINGER, Jeffrey O

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Fiber-reinforced calcium phosphate cement formulations for cranioplasty applications: A 52-week duration preclinical rabbit calvaria study by Kim, Jinku, McBride, Sean, Fulmer, Mark, Harten, Robert, Garza, Zach, Dean, David D., Sylvia, Victor L., Doll, Bruce, Wolfgang, Tahlia L, Gruskin, Elliott, Hollinger, Jeffrey O.

“…The in vivo tissue response to a newly developed fiber‐reinforced calcium phosphate cement (CPC) formulation was assessed using a well‐established rabbit…”
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Biodegradable Sleeves for Metal Implants to Prevent Implant-Associated Infection: An Experimental In Vivo Study in Sheep by von Plocki, Stephanie C., Armbruster, David, Klein, Karina, Kämpf, Käthi, Zlinszky, Katalin, Hilbe, Monika, Kronen, Peter, Gruskin, Elliott, von Rechenberg, Brigitte

“…ObjectiveTo evaluate biocompatibility of biodegradable sleeves containing antimicrobial agents, designed for local drug delivery to prevent implant‐related…”
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Role of bone substitutes by Hollinger, J O, Brekke, J, Gruskin, E, Lee, D

“…Approximately 500 million years ago, the Paleozoic era heralded an evolutionary marvel: the skeleton. Unique to this evolutionary development was the capacity…”
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Transforming growth factor-β1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model importance of oxygen and age by LIANCUN WU, XIA, Y.-P, ROTH, S. I, GRUSKIN, E, MUSTOE, T. A

“…Clinical trials of exogenous growth factors in treating chronic wounds have been less successful than expected. One possible explanation is that most studies…”
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Transforming growth factor-(beta) 1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: Importance of oxygen and age by Wu, Liancun, Yu-Ping, Xia, Roth, Sanford I, Gruskin, Elliott, Mustoe, Thomas A

“…Clinical trials of exogenous growth factors in treating chronic wounds have been less successful than expected. One possible explanation is that most studies…”
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Initial biocompatibility studies of a novel degradable polymeric bone substitute that hardens in situ by Bennett, Steven, Connolly, Kevin, Lee, Daniel R., Jiang, Ying, Buck, Dave, Hollinger, Jeffrey O., Gruskin, Elliott A.

“…Clinical management of osseous defects often requires bone grafts. The standard for treatment is autogenous bone harvested from sites such as either the iliac…”
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Differential Effects of Platelet-Derived Growth Factor BB in Accelerating Wound Healing in Aged versus Young Animals: The Impact of Tissue Hypoxia by Wu, Liancun, Brucker, Michael, Gruskin, Elliott, Roth, Sanford I, Mustoe, Thomas A

“…Platelet-derived growth factor BB (PDGF-BB) plays a central role in wound healing. Platelet-derived growth factor has been shown to accelerate healing in…”
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Biodegradable positively charged ion exchange beads: A novel biomaterial for enhancing soft tissue repair by Christoforou, Chris, Lin, Xuanhan, Bennett, Steve, Connors, Dave, Skalla, Walt, Mustoe, Thomas A., Linehan, Jackie, Arnold, Frank, Gruskin, Elliott A.

“…Previous work in the area of vulnerary agents is extensive. One material of focus has been positively charged ion exchange beads, which have been shown to…”
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