Search Results - "Gruol, Donna L."

IL-6 regulation of synaptic function in the CNS by Gruol, Donna L.

“…A growing body of evidence supports a role for glial-produced neuroimmune factors, including the cytokine IL-6, in CNS physiology and pathology. CNS expression…”
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Neuroimmune actions in the brain and interactions with the effects of alcohol by Gruol, Donna

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Impact of Elevated Brain IL-6 in Transgenic Mice on the Behavioral and Neurochemical Consequences of Chronic Alcohol Exposure by Gruol, Donna L, Calderon, Delilah, Huitron-Resendiz, Salvador, Cates-Gatto, Chelsea, Roberts, Amanda J

“…Alcohol consumption activates the neuroimmune system of the brain, a system in which brain astrocytes and microglia play dominant roles. These glial cells…”
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Impact of Increased Astrocyte Expression of IL-6, CCL2 or CXCL10 in Transgenic Mice on Hippocampal Synaptic Function by Gruol, Donna L

“…An important aspect of CNS disease and injury is the elevated expression of neuroimmune factors. These factors are thought to contribute to processes ranging…”
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The Neuroimmune System and the Cerebellum by Gruol, Donna L.

“…Abstract The recognition that there is an innate immune system of the brain, referred to as the neuroimmune system, that preforms many functions comparable to…”
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Emergence of NMDAR-independent long-term potentiation at hippocampal CA1 synapses following early adolescent exposure to chronic intermittent ethanol: Role for sigma-receptors by Sabeti, Jilla, Gruol, Donna L.

“…Adolescent humans who abuse alcohol are more vulnerable than adults to the development of memory impairments. Memory impairments often involve modifications in…”
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The chemokine CCL2 activates p38 mitogen-activated protein kinase pathway in cultured rat hippocampal cells by Cho, Jungsook, Gruol, Donna L

“…Abstract Emerging evidence indicates that chemokines can regulate both the physiology and biochemistry of CNS neurons and glia. In the current study, Western…”
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Steroid pregnenolone sulfate enhances NMDA-receptor-independent long-term potentiation at hippocampal CA1 synapses: Role for L-type calcium channels and sigma-receptors by Sabeti, Jilla, Nelson, Thomas E., Purdy, Robert H., Gruol, Donna L.

“…Severe stress elevates plasma and CNS levels of endogenous neuroactive steroids that can contribute to the influence of stress on memory formation. Among the…”
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The chemokine CXCL10 modulates excitatory activity and intracellular calcium signaling in cultured hippocampal neurons by Nelson, Thomas E., Gruol, Donna L.

“…In this study, we provide evidence for direct modulatory effects of the chemokine, CXCL10, on the physiology of hippocampal neurons maintained in primary…”
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Increased IL-6 expression in astrocytes is associated with emotionality, alterations in central amygdala GABAergic transmission, and excitability during alcohol withdrawal by Roberts, Amanda J., Khom, Sophia, Bajo, Michal, Vlkolinsky, Roman, Polis, Ilham, Cates-Gatto, Chelsea, Roberto, Marisa, Gruol, Donna L.

“…•Persistent expression of IL-6 by astrocytes alters brain biology and behavior.•IL-6 plays a role in responses to novelty and depressive-like…”
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Neuroimmune interactions with binge alcohol drinking in the cerebellum of IL-6 transgenic mice by Gruol, Donna L., Calderon, Delilah, French, Katharine, Melkonian, Claudia, Huitron-Resendiz, Salvador, Cates-Gatto, Chelsea, Roberts, Amanda J.

“…The neuroimmune system of the brain, which is comprised primarily of astrocytes and microglia, regulates a variety of homeostatic mechanisms that underlie…”
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Alcohol Enhances Responses to High Frequency Stimulation in Hippocampus from Transgenic Mice with Increased Astrocyte Expression of IL-6 by Gruol, Donna L., Hernandez, Ruben V., Roberts, Amanda

“…Recent studies show that alcohol exposure can induce glial production of neuroimmune factors in the CNS. Of these, IL-6 has gained attention because it is…”
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Alcohol and IL-6 Alter Expression of Synaptic Proteins in Cerebellum of Transgenic Mice with Increased Astrocyte Expression of IL-6 by Gruol, Donna L., Melkonian, Claudia, Ly, Kristine, Sisouvanthong, Jasmin, Tan, Yvette, Roberts, Amanda J.

“…[Display omitted] •IL-6 and alcohol alter synaptic protein expression in the cerebellum.•Expression of the GABAAR α6 subunit is altered by both IL-6 and…”
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Ethanol Alters Opioid Regulation of Ca2+ Influx Through L-Type Ca2+ Channels in PC12 Cells by Gruol, Donna L., Nelson, Thomas E., Hao, Christine, Michael, Sarah, Vukojevic, Vladana, Ming, Yu, Terenius, Lars

“…Background:  Studies at the behavioral and synaptic level show that effects of ethanol on the central nervous system can involve the opioid signaling system…”
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Alcohol alters IL-6 Signal Transduction in the CNS of Transgenic Mice with Increased Astrocyte Expression of IL-6 by Gruol, Donna L., Melkonian, Claudia, Huitron-Resendiz, Salvador, Roberts, Amanda J.

“…Neuroimmune factors, including the cytokine interleukin-6 (IL-6), are important chemical regulators of central nervous system (CNS) function under both…”
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Chronic Interleukin-6 Alters NMDA Receptor-Mediated Membrane Responses and Enhances Neurotoxicity in Developing CNS Neurons by Qiu, Zhihua, Sweeney, Dan D, Netzeband, Jeffrey G, Gruol, Donna L

“…Recent studies show that the cytokine interleukin-6 (IL-6) is expressed at elevated levels in the CNS in several disease states and contributes to the…”
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Altered brain activity during withdrawal from chronic alcohol is associated with changes in IL-6 signal transduction and GABAergic mechanisms in transgenic mice with increased astrocyte expression of IL-6 by Gruol, Donna L., Huitron-Resendiz, Salvador, Roberts, Amanda J.

“…Interleukin-6 (IL-6) is an important neuroimmune factor that is increased in the brain by alcohol exposure/withdrawal and is thought to play a role in the…”
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Transgenic Mice with Increased Astrocyte Expression of CCL2 Show Altered Behavioral Effects of Alcohol by Bray, Jennifer G, Roberts, Amanda J, Gruol, Donna L

“…Highlights • Increased CNS expression of CCL2 reduced alcohol consumption. • Both dependent and non-dependent mice showed altered behavior. • Increased CNS…”
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Rapamycin-Sensitive Late-LTP is Enhanced in the Hippocampus of IL-6 Transgenic Mice by Olde Engberink, Anneke, Hernandez, Ruben, de Graan, Pierre, Gruol, Donna L.

“…•Elevated CNS expression of IL-6 increases the late form of LTP in the hippocampus.•Rapamycin, an antagonist of mTOR, reduced genotypic differences in…”
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Altered hippocampal synaptic function in transgenic mice with increased astrocyte expression of CCL2 after withdrawal from chronic alcohol by Bray, Jennifer G., Reyes, Kenneth C., Roberts, Amanda J., Gruol, Donna L.

“…CNS actions of the chemokine CCL2 are thought to play a role in a variety of conditions that can have detrimental consequences to CNS function, including…”
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