Search Results - "Grunkemeyer, James A"

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis by Roe, Jae-Seok, Hwang, Chang-Il, Somerville, Tim D.D., Milazzo, Joseph P., Lee, Eun Jung, Da Silva, Brandon, Maiorino, Laura, Tiriac, Hervé, Young, C. Megan, Miyabayashi, Koji, Filippini, Dea, Creighton, Brianna, Burkhart, Richard A., Buscaglia, Jonathan M., Kim, Edward J., Grem, Jean L., Lazenby, Audrey J., Grunkemeyer, James A., Hollingsworth, Michael A., Grandgenett, Paul M., Egeblad, Mikala, Park, Youngkyu, Tuveson, David A., Vakoc, Christopher R.

“…Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensity for metastasis. Here, we used an organoid…”
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SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells by Wuebben, Erin L, Wilder, Phillip J, Cox, Jesse L, Grunkemeyer, James A, Caffrey, Thomas, Hollingsworth, Michael A, Rizzino, Angie

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly deadly malignancy. Expression of the stem cell transcription factor SOX2 increases during progression of…”
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Transcriptomic changes and gene fusions during the progression from Barrett's esophagus to esophageal adenocarcinoma by Fu, Yusi, Agrawal, Swati, Snyder, Daniel R, Yin, Shiwei, Zhong, Na, Grunkemeyer, James A, Dietz, Nicholas, Corlett, Ryan, Hansen, Laura A, Waddah, Al-Refaie, Nandipati, Kalyana C, Xia, Jun

“…The incidence of esophageal adenocarcinoma (EAC) has surged by 600% in recent decades, with a dismal 5-year survival rate of just 15%. Barrett's esophagus…”
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Engrailed‐1 Promotes Pancreatic Cancer Metastasis by Xu, Jihao, Roe, Jae‐Seok, Lee, EunJung, Tonelli, Claudia, Ji, Keely Y., Younis, Omar W., Somervile, Tim D.D., Yao, Melissa, Milazzo, Joseph P., Tiriac, Herve, Kolarzyk, Anna M., Lee, Esak, Grem, Jean L., Lazenby, Audrey J., Grunkemeyer, James A., Hollingsworth, Michael A., Grandgenett, Paul M., Borowsky, Alexander D., Park, Youngkyu, Vakoc, Christopher R., Tuveson, David A., Hwang, Chang‐Il

“…Engrailed‐1 (EN1) is a critical homeodomain transcription factor (TF) required for neuronal survival, and EN1 expression has been shown to promote aggressive…”
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Determinants of Vascular Permeability in the Kidney Glomerulus by Hamano, Yuki, Grunkemeyer, James A, Sudhakar, Akulapalli, Zeisberg, Michael, Cosgrove, Dominic, Morello, Roy, Lee, Brendan, Sugimoto, Hikaru, Kalluri, Raghu

“…The human kidneys filter 70 liters of blood plasma every day. The hallmark of almost all kidney diseases, whether acquired or genetic, is the leakage of plasma…”
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CD2-associated Protein (CD2AP) Expression in Podocytes Rescues Lethality of CD2AP Deficiency by Grunkemeyer, James A, Kwoh, Christopher, Huber, Tobias B, Shaw, Andrey S

“…Mice born without CD2-associated protein (CD2AP) develop renal failure and nephrotic syndrome about 4 weeks after birth and die around 6 weeks of age. Although…”
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Membrane structure and internalization dynamics of human Flower isoforms hFWE3 and hFWE4 indicate a conserved endocytic role for hFWE4 by Rudd, Justin C., Maity, Sibaprasad, Grunkemeyer, James A., Snyder, Joshua C., Lovas, Sándor, Hansen, Laura A.

“…Human Flower (hFWE) isoforms hFWE1-4 are putative transmembrane (TM) proteins that reportedly mediate fitness comparisons during cell competition through…”
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Isoforms of MUC16 activate oncogenic signaling through EGF receptors to enhance the progression of pancreatic cancer by Thomas, Divya, Sagar, Satish, Liu, Xiang, Lee, Hye-Rim, Grunkemeyer, James A., Grandgenett, Paul M., Caffrey, Thomas, O’Connell, Kelly A., Swanson, Benjamin, Marcos-Silva, Lara, Steentoft, Catharina, Wandall, Hans H., Maurer, Hans Carlo, Peng, Xianlu Laura, Yeh, Jen Jen, Qiu, Fang, Yu, Fang, Madiyalakan, Ragupathy, Olive, Kenneth P., Mandel, Ulla, Clausen, Henrik, Hollingsworth, Michael A., Radhakrishnan, Prakash

“…Aberrant expression of CA125/MUC16 is associated with pancreatic ductal adenocarcinoma (PDAC) progression and metastasis. However, knowledge of the…”
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IgE-Based Therapeutic Combination Enhances Antitumor Response in Preclinical Models of Pancreatic Cancer by Markov, Spas Dimitrov, Caffrey, Thomas C, O'Connell, Kelly A, Grunkemeyer, James A, Shin, Simon, Hanson, Ryan, Patil, Prathamesh P, Shukla, Surendra K, Gonzalez, Daisy, Crawford, Ayrianne J, Vance, Krysten E, Huang, Ying, Eberle, Kirsten C, Radhakrishnan, Prakash, Grandgenett, Paul M, Singh, Pankaj K, Madiyalakan, Ragupathy, Daniels-Wells, Tracy R, Penichet, Manuel L, Nicodemus, Christopher F, Poole, Jill A, Jaffee, Elizabeth M, Hollingsworth, Michael A, Mehla, Kamiya

“…Pancreatic ductal adenocarcinoma (PDAC) represents 3% of all cancer cases and 7% of all cancer deaths in the United States. Late diagnosis and inadequate…”
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Combination of mAb-AR20.5, anti-PD-L1 and PolyICLC inhibits tumor progression and prolongs survival of MUC1.Tg mice challenged with pancreatic tumors by Mehla, Kamiya, Tremayne, Jarrod, Grunkemeyer, James A., O’Connell, Kelly A., Steele, Maria M., Caffrey, Thomas C., Zhu, Xinyi, Yu, Fang, Singh, Pankaj K., Schultes, Birgit C., Madiyalakan, Ragupathy, Nicodemus, Christopher F., Hollingsworth, Michael A.

“…A substantial body of evidence suggests the existence of MUC1-specific antibodies and cytotoxic T cell activities in pancreatic cancer patients. However,…”
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Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis by Liu, Xiang, Clemens, Dahn L., Grunkemeyer, James A., Price, Jeffrey D., O’Connell, Kelly, Chapman, Nora M., Storz, Peter, Wen, Haitao, Cox, Jesse L., Reid, Whitney L., Hollingsworth, Michael A., Thayer, Sarah

“…The Muc-1 oncoprotein is a tumor-associated mucin often overexpressed in pancreatic cancer. We report that knockout of Muc-1 reduced the degree of pancreatic…”
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Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis by Hanson, Ryan L, Brown, Roger B, Steele, Maria M, Grandgenett, Paul M, Grunkemeyer, James A, Hollingsworth, Michael A

“…The MUC1 glycoprotein is overexpressed and aberrantly glycosylated in >90% of pancreatic ductal adenocarcinoma cases and impacts tumor progression by…”
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Distinct Antitumor Properties of a Type IV Collagen Domain Derived from Basement Membrane by Maeshima, Yohei, Colorado, Pablo C., Torre, Adriana, Holthaus, Kathryn A., Grunkemeyer, James A., Ericksen, Mark B., Hopfer, Helmut, Xiao, Yingwen, Stillman, Isaac E., Kalluri, Raghu

“…Vascular basement membrane is an important structural component of blood vessels. During angiogenesis this membrane undergoes many alterations and these…”
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Blocking angiotensin II synthesis/activity preserves glomerular nephrin in rats with severe nephrosis by BENIGNI, Ariela, TOMASONI, Susanna, GAGLIARDINI, Elena, ZOJA, Carla, GRUNKEMEYER, James A, KALLURI, Raghu, REMUZZI, Giuseppe

“…Angiotensin-converting enzyme inhibitors restore size-selective dysfunction of the glomerular barrier in experimental animals and humans with proteinuric…”
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IgE-based therapeutic combination enhances anti-tumor response in preclinical models of pancreatic cancer by Markov, Spas Dimitrov, Caffrey, Thomas C., O’Connell, Kelly A., Grunkemeyer, James A., Shin, Simon, Hanson, Ryan, Patil, Prathamesh P., Shukla, Surendra K., Gonzalez, Daisy, Crawford, Ayrianne J., Vance, Krysten E., Huang, Ying, Eberle, Kirsten C., Radhakrishnan, Prakash, Grandgenett, Paul M., Singh, Pankaj K., Madiyalakan, Ragupathy, Daniels-Wells, Tracy R., Penichet, Manuel L., Nicodemus, Christopher F., Poole, Jill A., Jaffee, Elizabeth M., Hollingsworth, Michael A., Mehla, Kamiya

“…Pancreatic ductal adenocarcinoma (PDAC) represents 3% of all cancer cases and 7% of all cancer deaths in the United States. Late diagnosis and inadequate…”
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Abstract 813: Development of a porcine model for pancreatic cancer by Remmers, Neeley A., Cox, Jesse L., Grandgenett, Paul M., Grunkemeyer, James A., Rund, Laurie A., Schook, Lawrence B., Hollingsworth, Michael A., Carlson, Mark A.

“…Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year survival rate of 4%. Without significant advances in early detection and…”
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Truncated O ‐ glycans Enhance Tumorigenicity of Pancreatic Tumors by Radhakrishnan, Prakash, Grunkemeyer, James A, Clausen, Henrik, Hollingsworth, Michael A

“…Abstract only The interaction between cancer cell surface mucins and growth factor receptors enhances the tumorigenesis of pancreatic adenocarcinoma (PDAC)…”
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Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome by Cosgrove, D, Meehan, D T, Grunkemeyer, J A, Kornak, J M, Sayers, R, Hunter, W J, Samuelson, G C

“…A mouse model for the autosomal form of Alport syndrome was produced. These mice develop a progressive glomerulonephritis with microhematuria and proteinuria,…”
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