Search Results - "Grunewald, Thomas G.P"

YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1 by Somasekharan, Syam Prakash, El-Naggar, Amal, Leprivier, Gabriel, Cheng, Hongwei, Hajee, Shamil, Grunewald, Thomas G P, Zhang, Fan, Ng, Tony, Delattre, Olivier, Evdokimova, Valentina, Wang, Yuzhuo, Gleave, Martin, Sorensen, Poul H

“…Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is to sequester and silence mRNAs in ribonucleoprotein complexes…”
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Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis by El-Naggar, Amal M., Veinotte, Chansey J., Cheng, Hongwei, Grunewald, Thomas G.P., Negri, Gian Luca, Somasekharan, Syam Prakash, Corkery, Dale P., Tirode, Franck, Mathers, Joan, Khan, Debjit, Kyle, Alastair H., Baker, Jennifer H., LePard, Nancy E., McKinney, Steven, Hajee, Shamil, Bosiljcic, Momir, Leprivier, Gabriel, Tognon, Cristina E., Minchinton, Andrew I., Bennewith, Kevin L., Delattre, Olivier, Wang, Yuzhuo, Dellaire, Graham, Berman, Jason N., Sorensen, Poul H.

“…Metastatic dissemination is the leading cause of death in cancer patients, which is particularly evident for high-risk sarcomas such as Ewing sarcoma,…”
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PBX3 Is Part of an EMT Regulatory Network and Indicates Poor Outcome in Colorectal Cancer by Lamprecht, Sebastian, Kaller, Markus, Schmidt, Eva Marina, Blaj, Cristina, Schiergens, Tobias S, Engel, Jutta, Jung, Andreas, Hermeking, Heiko, Grünewald, Thomas G P, Kirchner, Thomas, Horst, David

“…Colorectal cancers are composed of phenotypically different tumor cell subpopulations within the same core genetic background. Here, we identify high…”
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DKK2 Mediates Osteolysis, Invasiveness, and Metastatic Spread in Ewing Sarcoma by HAUER, Kristina, CALZADA-WACK, Julia, RICHTER, Günther H. S, STEIGER, Katja, GRUNEWALD, Thomas G. P, BAUMHOER, Daniel, PLEHM, Stephanie, BUCH, Thorsten, DA COSTA, Olivia Prazeres, ESPOSITO, Irene, BURDACH, Stefan

“…Ewing sarcoma, an osteolytic malignancy that mainly affects children and young adults, is characterized by early metastasis to lung and bone. In this study, we…”
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A single-sample workflow for joint metabolomic and proteomic analysis of clinical specimens by Gegner, Hagen M, Naake, Thomas, Aljakouch, Karim, Dugourd, Aurelien, Kliewer, Georg, Müller, Torsten, Schilling, Dustin, Schneider, Marc A, Kunze-Rohrbach, Nina, Grünewald, Thomas G P, Hell, Rüdiger, Saez-Rodriguez, Julio, Huber, Wolfgang, Poschet, Gernot, Krijgsveld, Jeroen

“…Understanding the interplay of the proteome and the metabolome helps to understand cellular regulation and response. To enable robust inferences from such…”
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Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma by Traenka, Christopher, Remke, Marc, Korshunov, Andrey, Bender, Sebastian, Hielscher, Thomas, Northcott, Paul A, Witt, Hendrik, Ryzhova, Marina, Felsberg, Jörg, Benner, Axel, Riester, Stephanie, Scheurlen, Wolfram, Grunewald, Thomas G P, von Deimling, Andreas, Kulozik, Andreas E, Reifenberger, Guido, Taylor, Michael D, Lichter, Peter, Butt, Elke, Pfister, Stefan M

“…Medulloblastoma is the most common malignant pediatric brain tumor and is one of the leading causes of cancer-related mortality in children. Treatment failure…”
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Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells by Grunewald, Thomas G.P., Kammerer, Ulrike, Schulze, Elfriede, Schindler, Detlef, Honig, Arnd, Zimmer, Michael, Butt, Elke

“…LIM and SH3 protein (LASP-1), initially identified from human breast cancer, is a specific focal adhesion protein involved in cell migration. LASP-1 is an…”
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Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma by Jansky, Selina, Sharma, Ashwini Kumar, Körber, Verena, Quintero, Andrés, Toprak, Umut H., Wecht, Elisa M., Gartlgruber, Moritz, Greco, Alessandro, Chomsky, Elad, Grünewald, Thomas G. P., Henrich, Kai-Oliver, Tanay, Amos, Herrmann, Carl, Höfer, Thomas, Westermann, Frank

“…Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system. However, the cellular origin of neuroblastoma has yet to be defined. Here we…”
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Cell Adhesion and Transcriptional Activity — Defining the Role of the Novel Protooncogene LPP by Grunewald, Thomas G.P., Pasedag, Saskia M., Butt, Elke

“…Integrating signals from the extracellular matrix through the cell surface into the nucleus is an essential feature of metazoan life. To date, many signal…”
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MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival by Wernicke, Caroline M, Richter, Günther H.S, Beinvogl, Beate C, Plehm, Stephanie, Schlitter, Anna M, Bandapalli, Obul R, Prazeres da Costa, Olivia, Hattenhorst, Uwe E, Volkmer, Ines, Staege, Martin S, Esposito, Irene, Burdach, Stefan, Grunewald, Thomas G.P

“…Abstract Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. To identify novel candidates for targeted therapy, we performed a…”
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Epithelial-to-Mesenchymal and Mesenchymal-to-Epithelial Transition in Mesenchymal Tumors: A Paradox in Sarcomas? by Sannino, Giuseppina, Marchetto, Aruna, Kirchner, Thomas, Grünewald, Thomas G P

“…The epithelial-to-mesenchymal transition (EMT) is a reversible process comprised of various subprograms via which epithelial cells reduce their intercellular…”
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Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution by Aynaud, Marie-Ming, Mirabeau, Olivier, Gruel, Nadege, Grossetête, Sandrine, Boeva, Valentina, Durand, Simon, Surdez, Didier, Saulnier, Olivier, Zaïdi, Sakina, Gribkova, Svetlana, Fouché, Aziz, Kairov, Ulykbek, Raynal, Virginie, Tirode, Franck, Grünewald, Thomas G.P., Bohec, Mylene, Baulande, Sylvain, Janoueix-Lerosey, Isabelle, Vert, Jean-Philippe, Barillot, Emmanuel, Delattre, Olivier, Zinovyev, Andrei

“…EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains…”
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Unraveling Ewing Sarcoma Tumorigenesis Originating from Patient-Derived Mesenchymal Stem Cells by Sole, Anna, Grossetête, Sandrine, Heintzé, Maxime, Babin, Loelia, Zaïdi, Sakina, Revy, Patrick, Renouf, Benjamin, De Cian, Anne, Giovannangeli, Carine, Pierre-Eugène, Cécile, Janoueix-Lerosey, Isabelle, Couronné, Lucile, Kaltenbach, Sophie, Tomishima, Mark, Jasin, Maria, Grünewald, Thomas G P, Delattre, Olivier, Surdez, Didier, Brunet, Erika

“…Ewing sarcoma is characterized by pathognomonic translocations, most frequently fusing with . An estimated 30% of Ewing sarcoma tumors also display genetic…”
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Tissue Preservation and FFPE Samples: Optimized Nucleic Acids Isolation in Ewing Sarcoma by Romero-Pérez, Laura, Grünewald, Thomas G P

“…Different methods have been described for the preservation of biopsy or resection samples. In the routine pathology, the cheapest and most commonly used is…”
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Sclerosing Epithelioid Fibrosarcoma of the Bone: A Case Report of High Resistance to Chemotherapy and a Survey of the Literature by Grunewald, Thomas G. P., von Luettichau, Irene, Weirich, Gregor, Wawer, Angela, Behrends, Uta, Prodinger, Peter M., Jundt, Gernot, Bielack, Stefan S., Gradinger, Reiner, Burdach, Stefan

“…Sclerosing epithelioid fibrosarcoma (SEF) is a rare soft tissue sarcoma mostly occurring in extraosseous sites. SEF represents a clinically challenging entity…”
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(Immuno)histological Analysis of Ewing Sarcoma by Marcilla, David, Machado, Isidro, Grünewald, Thomas G P, Llombart-Bosch, Antonio, de Álava, Enrique

“…The diagnosis of Ewing sarcoma requires the integration of the information generated from numerous techniques, some of them being very sophisticated. However,…”
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Focal adhesion kinase confers pro‐migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma by Steinestel, Konrad, Trautmann, Marcel, Jansen, Esther‐Pia, Dirksen, Uta, Rehkämper, Jan, Mikesch, Jan‐Henrik, Gerke, Julia S., Orth, Martin F., Sannino, Giuseppina, Arteaga, Maria‐Francisca, Rossig, Claudia, Wardelmann, Eva, Grünewald, Thomas G. P., Hartmann, Wolfgang

“…Oncogenesis of Ewing sarcoma (EwS), the second most common malignant bone tumor of childhood and adolescence, is dependent on the expression of chimeric…”
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Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays by Willier, Semjon, Butt, Elke, Grunewald, Thomas G. P.

“…ABSTRACT Lysophosphatidic acid (LPA) is a ubiquitously present signalling molecule involved in diverse cellular processes such as cell migration, proliferation…”
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Tumour-derived exosomes: Tiny envelopes for big stories by Miller, Isabella V., Grunewald, Thomas G. P.

“…The discovery of exosomes, which are small, 30–100 nm sized extracellular vesicles that are released by virtual all cells, has initiated a rapidly expanding…”
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The STEAP protein family: Versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions by Grunewald, Thomas G. P., Bach, Horacio, Cossarizza, Andrea, Matsumoto, Isao

“…The human six‐transmembrane epithelial antigen of the prostate (STEAP) protein family contains at least five homologous members. The necessity of multiple…”
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