Search Results - "Grundy, Laura J"
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dictionary of behavioral motifs reveals clusters of genes affecting Caenorhabditis elegans locomotion
Published in Proceedings of the National Academy of Sciences - PNAS (08-01-2013)“…Visible phenotypes based on locomotion and posture have played a critical role in understanding the molecular basis of behavior and development in…”
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An open-source platform for analyzing and sharing worm-behavior data
Published in Nature methods (01-09-2018)Get full text
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Automated and controlled mechanical stimulation and functional imaging in vivo in C. elegans
Published in Lab on a chip (07-08-2017)“…C. elegans is a useful genetic model system for investigating mechanisms involved in sensory behavior which are potentially relevant to human diseases. While…”
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Changes in Postural Syntax Characterize Sensory Modulation and Natural Variation of C. elegans Locomotion
Published in PLoS computational biology (01-08-2015)“…Locomotion is driven by shape changes coordinated by the nervous system through time; thus, enumerating an animal's complete repertoire of shape transitions…”
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PACRG, a protein linked to ciliary motility, mediates cellular signaling
Published in Molecular biology of the cell (01-07-2016)“…Cilia are microtubule-based organelles that project from nearly all mammalian cell types. Motile cilia generate fluid flow, whereas nonmotile (primary) cilia…”
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EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling
Published in eLife (27-02-2019)“…Neurons throughout the mammalian brain possess non-motile cilia, organelles with varied functions in sensory physiology and cellular signaling. Yet, the roles…”
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A database of Caenorhabditis elegans behavioral phenotypes
Published in Nature methods (01-09-2013)“…A growing collection of segmented and feature-extracted videos recording locomotive behavior in hundreds of C. elegans mutant strains is made available for…”
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The diverse functions of the DEG/ENaC family: linking genetic and physiological insights
Published in The Journal of physiology (01-05-2023)“…The DEG/ENaC family of ion channels was defined based on the sequence similarity between degenerins (DEG) from the nematode Caenorhabditis elegans and subunits…”
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Neuropeptides encoded by nlp-49 modulate locomotion, arousal and egg-laying behaviours in Caenorhabditis elegans via the receptor SEB-3
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (10-09-2018)“…Neuropeptide signalling has been implicated in a wide variety of biological processes in diverse organisms, from invertebrates to humans. The Caenorhabditis…”
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Neuropeptides encoded by nlp-49 modulate locomotion, arousal and egg-laying behaviours in Caenorhabditis elegans via the receptor SEB-3
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (19-10-2018)“…Neuropeptide signalling has been implicated in a wide variety of biological processes in diverse organisms, from invertebrates to humans. The Caenorhabditis…”
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A database of C. elegans behavioral phenotypes
Published in Nature methods (14-07-2013)“…Using low-cost automated tracking microscopes, we have generated a behavioral database for 305 C. elegans strains, including 76 mutants with no previously…”
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Changes in Postural Syntax Characterize Sensory Modulation and Natural Variation of C . elegans Locomotion: e1004322
Published in PLoS computational biology (01-08-2015)“…Locomotion is driven by shape changes coordinated by the nervous system through time; thus, enumerating an animal's complete repertoire of shape transitions…”
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