Search Results - "Grun, Felix"

Environmental Obesogens: Organotins and Endocrine Disruption via Nuclear Receptor Signaling by Grün, Felix, Blumberg, Bruce

“…Over the last two decades, the incidence of obesity and associated metabolic syndrome diseases has risen dramatically, becoming a global health crisis…”
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Endocrine-Disrupting Organotin Compounds Are Potent Inducers of Adipogenesis in Vertebrates by Grün, Felix, Watanabe, Hajime, Zamanian, Zamaneh, Maeda, Lauren, Arima, Kayo, Cubacha, Ryan, Gardiner, David M, Kanno, Jun, Iguchi, Taisen, Blumberg, Bruce

“…Dietary and xenobiotic compounds can disrupt endocrine signaling, particularly of steroid receptors and sexual differentiation. Evidence is also mounting that…”
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Mutual repression between steroid and xenobiotic receptor and NF-κB signaling pathways links xenobiotic metabolism and inflammation by Zhou, Changcheng, Tabb, Michelle M, Nelson, Edward L, Grun, Felix, Verma, Suman, Sadatrafiei, Asal, Lin, Min, Mallick, Shyamali, Forman, Barry M, Thummel, Kenneth E, Blumberg, Bruce

“…While it has long been known that inflammation and infection reduce expression of hepatic cytochrome P450 (CYP) genes involved in xenobiotic metabolism and…”
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Spatially resolved detection of small molecules from press-dried plant tissue using MALDI imaging by Long, Zane G, Le, Jonathan V, Katz, Benjamin B, Lopez, Belen G, Tenenbaum, Emily D, Semmling, Bonnie, Schmidt, Ryan J, Grün, Felix, Butts, Carter T, Martin, Rachel W

“…Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a chemical imaging method that can visualize spatial distributions of…”
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The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor by Zhou, Changcheng, Poulton, Emma-Jane, Grün, Felix, Bammler, Theo K, Blumberg, Bruce, Thummel, Kenneth E, Eaton, David L

“…Sulforaphane (SFN) is a biologically active phytochemical found abundantly in broccoli. SFN has been promoted as a putative chemopreventive agent to reduce…”
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Highly Chlorinated PCBs Inhibit the Human Xenobiotic Response Mediated by the Steroid and Xenobiotic Receptor (SXR) by Tabb, Michelle M., Kholodovych, Vladyslav, Grün, Felix, Zhou, Changcheng, Welsh, William J., Blumberg, Bruce

“…Polychlorinated biphenyls (PCBs) are a family of persistent organic contaminants suspected to cause adverse effects in wildlife and humans. In rodents, PCBs…”
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Activation of steroid and xenobiotic receptor (SXR, NR1I2) and its orthologs in laboratory, toxicologic, and genome model species by Milnes, Matthew R, Garcia, Adriana, Grossman, Emily, Grün, Felix, Shiotsugu, Jason, Tabb, Michelle M, Kawashima, Yukio, Katsu, Yoshinao, Watanabe, Hajime, Iguchi, Taisen, Blumberg, Bruce

“…Nuclear receptor subfamily 1, group I, member 2 (NR1I2), commonly known as steroid and xenobiotic receptor (SXR) in humans, is a key ligand-dependent…”
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Minireview: The Case for Obesogens by Grün, Felix, Blumberg, Bruce

“…Obesity and obesity-related disorders, such as type 2 diabetes, hypertension, and cardiovascular disease, are epidemic in Western countries, particularly the…”
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Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis by Grün, Felix, Blumberg, Bruce

“…The modern world is plagued with expanding epidemics of diseases related to metabolic dysfunction. The factors that are driving obesity, diabetes,…”
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"You Never Get a Second Chance": First Impressions of Physicians Depend on Their Body Posture and Gender by Grün, Felix C, Heibges, Maren, Westfal, Viola, Feufel, Markus A

“…A first impression matters, in particular when encounters are brief as in most doctor-patient interactions. In this study, we investigate how physicians' body…”
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Breath biomarkers of total body irradiation in non-human primates by Phillips, Michael, Grun, Felix, Schmitt, Peter

“…Radiation exposure causes oxidative stress, eliciting production of metabolites that are exhaled in the breath as volatile organic compounds (VOCs). We…”
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Towards Scenario- and Capability-Driven Dataset Development and Evaluation: An Approach in the Context of Mapless Automated Driving by Grun, Felix, Nolte, Marcus, Maurer, Markus

“…The foundational role of datasets in defining the capabilities of deep learning models has led to their rapid proliferation. At the same time, published…”
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Vitamin K2 Regulation of Bone Homeostasis Is Mediated by the Steroid and Xenobiotic Receptor SXR by Tabb, Michelle M., Sun, Aixu, Zhou, Changcheng, Grün, Felix, Errandi, Jody, Romero, Kimberly, Pham, Hang, Inoue, Satoshi, Mallick, Shyamali, Lin, Min, Forman, Barry M., Blumberg, Bruce

“…Vitamin K2 is a critical nutrient required for blood clotting that also plays an important role in bone formation. Vitamin K2 supplementation up-regulates the…”
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Diabetes60 - Inferring Bread Units From Food Images Using Fully Convolutional Neural Networks by Christ, Patrick Ferdinand, Schlecht, Sebastian, Ettlinger, Florian, Grun, Felix, Heinle, Christoph, Tatavatry, Sunil, Ahmadi, Seyed-Ahmad, Diepold, Klaus, Menze, Bjoern H.

“…In this paper we propose a challenging new computer vision task of inferring Bread Units (BUs) from food images. Assessing nutritional information and nutrient…”
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Spatially resolved detection of small molecules from press-dried plant tissue using MALDI imaging by Long, Zane, Le, Jonathan V., Katz, Benjamin, Lopez, Belen G., Tenenbaum, Emily, Semling, Bonnie, Schmidt, Ryan, Grun, Felix, Butts, Carter T., Martin, Rachel W.

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TOCOTRIENOLS ACTIVATE THE STEROID AND XENOBIOTIC RECEPTOR, SXR, AND SELECTIVELY REGULATE EXPRESSION OF ITS TARGET GENES by CHANGCHENG ZHOU, TABB, Michelle M, SADATRAFIEI, Asal, GRÜN, Felix, BLUMBERG, Bruce

“…Vitamin E is an essential nutrient with antioxidant activity. Vitamin E is comprised of eight members, α-, β-, γ-, and δ-tocopherols and α-, β-, γ-, and…”
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Liquid Chromatography Mass Spectrometry Detection of Antibiotic Agents in Sputum from Persons with Cystic Fibrosis by Gallagher, Tara, Riedel, Stefan, Kapcia, Joseph, Caverly, Lindsay J, Carmody, Lisa, Kalikin, Linda M, Lu, Junnan, Phan, Joann, Gargus, Matthew, Kagawa, Miki, Leemans, Simon W, Rothman, Jason A, Grun, Felix, LiPuma, John J, Whiteson, Katrine L

“…Antibiotic therapy is expected to impact host microbial communities considerably, yet many studies focused on microbiome and health are often confounded by…”
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Retinoic acid signaling in the brain marks formation of optic projections, maturation of the dorsal telencephalon, and function of limbic sites by Luo, Tuanlian, Wagner, Elisabeth, Grün, Felix, Dräger, Ursula C.

“…As retinoic acid (RA) is known to regulate the expression of many neuronal proteins, it is likely to influence overall development and function of the brain;…”
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Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer by Sprowl-Tanio, Stephanie, Habowski, Amber N, Pate, Kira T, McQuade, Miriam M, Wang, Kehui, Edwards, Robert A, Grun, Felix, Lyou, Yung, Waterman, Marian L

“…There is increasing evidence that oncogenic Wnt signaling directs metabolic reprogramming of cancer cells to favor aerobic glycolysis or Warburg metabolism. In…”
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Aerobic function in mitochondria persists beyond death by heat stress in insects by Heinrich, Erica C., Gray, Emilie M., Ossher, Ashley, Meigher, Stephen, Grun, Felix, Bradley, Timothy J.

“…The critical thermal maximum (CTmax) of insects can be determined using flow-through thermolimit respirometry. It has been demonstrated that respiratory…”
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