Search Results - "Gruijl, T.D"

An organotypic human melanoma-in-skin model as an in vitro tool for testing Vγ9Vδ2-T cell-based immunotherapy by Michielon, E., King, L.A., Waaijman, T., Veth, M., Spiekstra, S.W., van der Vliet, H.J., Gibbs, S., de Gruijl, T.D.

“…Despite considerable advancements in cancer immunotherapy, advanced melanoma still presents a substantial clinical challenge. In an effort to explore treatment…”
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Ablation of locally advanced pancreatic carcinoma by percutaneous irreversible electroporation: Results of the phase I/II PANFIRE-study by Scheffer, H.J, Vroomen, L.G, Zonderhuis, B.M, Daams, F, Vogel, J.A, Besselink, M.G, van Kuijk, C, de Gruijl, T.D, van den Tol, P.M, Kazemier, G, Meijerink, M.R

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Pre-treatment tumor-infiltrating T cells influence response to neoadjuvant chemoradiotherapy in esophageal adenocarcinoma by Goedegebuure, R.S.A., Harrasser, M., de Klerk, L.K., van Schooten, T.S., van Grieken, N.C.T., Eken, M., Grifhorst, M.S., Pocorni, N., Jordanova, E.S., van Berge Henegouwen, M.I., Pouw, R.E., Verheul, H.M.W., van der Vliet, J.J., van Laarhoven, H.W.M., Thijssen, V.L.J.L, Bass, A.J., De Gruijl, T.D., Derks, S.

“…Esophageal adenocarcinoma (EAC) is a disease with dismal treatment outcomes. Response to neoadjuvant chemoradiation (CRT) varies greatly. Although the…”
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Increased cytotoxic capacity of tumor antigen specific human T cells after in vitro stimulation with IL21 producing dendritic cells by Turksma, A.W, Bontkes, H.J, Ruizendaal, J.J, van den Heuvel, H, Scholten, K.B.J, Santegoets, S.J.A.M, de Gruijl, T.D, Meijer, C.J.L.M, Hooijberg, E

“…Abstract Monocyte derived dendritic cells (moDC) electroporated with tumor associated antigen derived mRNA can elicit specific T cells against tumor cells in…”
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4-1BB-mediated expansion affords superior detection of in vivo primed effector memory CD8+ T cells from melanoma sentinel lymph nodes by Sluijter, B.J.R, van den Hout, M.F.C.M, Stam, A.G.M, Lougheed, S.M, Suhoski, M.M, van den Eertwegh, A.J.M, van den Tol, M.P, van Leeuwen, P.A.M, Meijer, S, Scheper, R.J, June, C.H, de Gruijl, T.D, Santegoets, S.J.A.M

“…Abstract We have been studying the re-activation of tumor-associated antigen (TAA)-specific CD8+ T cells in sentinel lymph nodes (SLN) of melanoma patients…”
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1303P Immune-modulating effects on tumor draining lymph nodes following neoadjuvant chemoradiotherapy combined with immunotherapy in patients with T3-4N0-1 NSCLC by Ulas, E.B., Vrijmoet, A., Koomen, S., Houda, I., Dickhoff, C., Bahce, I., Senan, S., de Gruijl, T.D., Fransen, M., van Maldegem, F., Radonic, T., Schneiders, F.

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950O Ipilimumab plus nivolumab and chemoradiotherapy followed by surgery in patients with resectable and borderline resectable lung cancer: The INCREASE trial by Bahce, I., Dickhoff, C., Schneiders, F.L., Veltman, J., Heineman, D.J., Hashemi, S., Fransen, M., Vrijmoet, A., Houda, I., Ulas, E., van de Ven, P., Bouwhuis, N., Meijboom, L., Oprea-Lager, D., Garcia Vallejo, J., de Gruijl, T.D., Radonic, T., Senan, S.

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Biological Concepts of Prolonged Neoadjuvant Treatment plus GM‐CSF in Locally Advanced Tumors by Pinedo, H.M., de Gruijl, T.D., van der Wall, E., Buter, J.

“…Local treatment with surgery and radiotherapy gives unsatisfactory results in patients with locally advanced cancer. In many cases distant metastases appear…”
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Local administration of immunotherapy for patients with skin cancer: A systematic review by Janssen, J.C., van Dijk, B., Hoeijmakers, L.L., Grünhagen, D.J., Bramer, W.M., Verhoef, C., de Gruijl, T.D., Blank, C.U., van der Veldt, A.A.M.

“…•Toxicity can be reduced by local administration of lower doses of immunotherapy.•This review provides a comprehensive overview of immunotherapeutics that are…”
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119TiP Dual-immunotherapy and short-course medium-dose radiotherapy, followed by surgery for tumor microenvironment modification in early stage NSCLC: The DIRECT-trial by Dickhoff, C., Senan, S., Schneiders, F.L., Veltman, J., Hashemi, S., Fransen, M., Heineman, D., Radonic, T., van de Ven, P., Bartelink, I.H., Meijboom, L., Oprea-Lager, D., Garcia-Vallejo, J., Bouwhuis, N., de Gruijl, T.D., Bahce, I.

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1020P Rescue by radiotherapy and anti-CTLA4/PD-1 after failure of anti-PD-1 therapy in metastatic NSCLC patients: The RECLAIM study by Bahce, I., Schneiders, F.L., Hashemi, S., Veltman, J., Daniels, H., Fransen, M., Radonic, T., Ulas, E., Houda, I., Barlo, N., Disselhorst, M., van Laren, M., Tiemessen, M., Tarasevych, S., van Haarst, J.M.M., van Tilburg, P., Kunst, P., Moons-Pasic, A., de Gruijl, T.D., Senan, S.

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LBA43 Intradermal IMO-2125 versus placebo as adjuvant treatment in patients with stage II pT3-4/cN0 melanoma: Interim efficacy and safety results of the randomized phase II INTRIM study by Notohardjo, J.C.L., Veenstra, S., Koster, B.D., Kandiah, V., van der Velde, S., Francken, A.B., Gooiker, G.A., van den Tol, M.P., Bekkenk, M.W., Hof, K.H. in 't, Straver, M.E., Molenkamp, B.G., Vuylsteke, R.J.C.L.M., Lissenberg-Witte, B.I., Labots, M., Chunduru, S.K., van Akkooi, A.C.J., Van Den Eertwegh, F., de Gruijl, T.D.

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Favorable outcome in clinically stage II melanoma patients is associated with the presence of activated tumor infiltrating T‐lymphocytes and preserved MHC class I antigen expression by van Houdt, Inge S., Sluijter, Berbel J.R., Moesbergen, Laura M., Vos, Wim M., de Gruijl, Tanja D., Molenkamp, Barbara G., van den Eertwegh, Alfons J.M., Hooijberg, Erik, van Leeuwen, Paul A.M., Meijer, Chris J.L.M., Oudejans, Joost J.

“…In this study we investigated whether the presence of specific populations of tumor infiltrating lymphocytes (TILs) in diagnostic primary melanoma biopsies are…”
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Dendritic cells require multidrug resistance protein 1 (ABCC1) transporter activity for differentation by Ven, R., van de, Jong, M.C.M., de, Reurs, A.W, Schoonderwoerd, A.J, Jansen, G, Hooijberg, J.H, Scheffer, G.L, Gruijl, T.D, Scheper, R.J

“…Dendritic cells (DC) express the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and multidrug resistance protein 1 (MRP1; ABCC1). Functionally,…”
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Extended neoadjuvant chemotherapy in locally advanced breast cancer combined with GM-CSF: effect on tumour-draining lymph node dendritic cells by Pinedo, H.M, Buter, J, Luykx-de Bakker, S.A, Pohlmann, P.R, van Hensbergen, Y, Heideman, D.A.M, van Diest, P.J, de Gruijl, T.D, van der Wall, E

“…The effect of long-term administration of granulocyte-macrophage colony-stimulating factor (GM-CSF) on dendritic cell (DC) activation and survival in patients…”
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Extended neoadjuvant chemotherapy in locally advanced breast cancer combined with GM-CSF by Pinedo, H.M, Buter, J, Luykx-de Bakker, S.A, Pohlmann, P.R, van Hensbergen, Y, Heideman, D.A.M, van Diest, P.J, de Gruijl, T.D, van der Wall, E

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Differences in cytokine mRNA profiles between premalignant and malignant lesions of the uterine cervix by de Gruijl, T.D, Bontkes, H.J, van den Muysenberg, A.J.C, van Oostveen, J.W, Stukart, M.J, Verheijen, R.H.M, van der Vange, N, Snijders, P.J.F, Meijer, C.J.L.M, Walboomers, J.M.M, Scheper, R.J

“…The aim of this study was to assess the expression of cytokine transcripts, reflecting the type of ongoing immune responses at the site of human papillomavirus…”
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Prolonged neoadjuvant treatment in locally advanced tumours: A novel concept based on biological considerations by Luykx-de Bakker, S. A., Verheul, H. M. W., de Gruijl, T. D., Pinedo, H. M.

“…Background: Neoadjuvant chemotherapy is increasingly applied in patients with locally advanced cancers of many tumour types. Usually three cycles of…”
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Increased CTL activation, as determined by TIA-1 and granzyme B expression, is found in CIN lesions with increasing dysplasia and in invasive carcinoma by Bontkes, H.J., de Gruijl, T.D., Walboomers, J.M.M., Scheper, R.J., Meijer, C.J.L.M., Kummer, J.A.

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Type-1 and Type-2 cytokine mRNA analysis in premalignant and malignant lesions of the cervix uteri by de Gruijl, T.D., Bontkes, H.J., Walboomers, J.M.M., van den Muysenberg, A.J.C., Verheijen, R.H.M., Meijer, C.J.L.M., Scheper, R.J.

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