Search Results - "Gruijl, T. D."

Immune checkpoint inhibition: from molecules to clinical application by Taams, L. S., Gruijl, T. D.

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Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer by Niemeijer, A. N., Leung, D., Huisman, M. C., Bahce, I., Hoekstra, O. S., van Dongen, G. A. M. S., Boellaard, R., Du, S., Hayes, W., Smith, R., Windhorst, A. D., Hendrikse, N. H., Poot, A., Vugts, D. J., Thunnissen, E., Morin, P., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M., de Gruijl, T. D., Smit, E. F., de Langen, A. J.

“…PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might…”
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'DURVIT': a phase-I trial of single low-dose durvalumab (Medi4736) IntraTumourally injected in cervical cancer: safety, toxicity and effect on the primary tumour- and lymph node microenvironment by Rotman, J, Mom, C H, Jordanova, E S, de Gruijl, T D, Kenter, G G

“…Treatment with programmed cell death receptor (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors is a promising strategy to lift tumour-induced…”
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Oncolytic adenovirus ORCA‐010 increases the type 1 T cell stimulatory capacity of melanoma‐conditioned dendritic cells by López González, M., Ven, R., Haan, H., Eck van der Sluijs, J., Dong, W., Beusechem, V. W., Gruijl, T. D.

“…Summary Immune checkpoint blockade has resulted in durable responses in patients with metastatic melanoma, but only in a fraction of treated patients. For…”
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Efficacy of PD-1 blockade in cervical cancer is related to a CD8 + FoxP3 + CD25 + T-cell subset with operational effector functions despite high immune checkpoint levels by Heeren, A M, Rotman, J, Stam, A G M, Pocorni, N, Gassama, A A, Samuels, S, Bleeker, M C G, Mom, C H, Zijlmans, H J M A A, Kenter, G G, Jordanova, E S, de Gruijl, T D

“…Cervical cancer (CxCa) is mainly a locally invading disease that metastasizes to loco-regional lymph node basins before involving distant organs in more…”
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Melanoma-specific tumor-infiltrating lymphocytes but not circulating melanoma-specific T cells may predict survival in resected advanced-stage melanoma patients by HAANEN, J. B. A. G, BAARS, A, PINEDO, H. M, VAN DEN EERTWEGH, A. J. M, GOMEZ, R, WEDER, P, SMITS, M, DE GRUIJL, T. D, VON BLOMBERG, B. M. E, BLOEMENA, E, SCHEPER, R. J, VAN HAM, S. M

“…To study the effect of autologous tumor cell vaccinations on the presence and numbers of circulating CD8+ T cells specific for tumor-associated antigens (TAA)…”
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Effector memory T-cell frequencies in relation to tumour stage, location and HPV status in HNSCC patients by Turksma, AW, Bontkes, HJ, van den Heuvel, H, de Gruijl, TD, von Blomberg, BME, Braakhuis, BJM, Leemans, CR, Bloemena, E, Meijer, CJLM, Hooijberg, E

“…Background The immune system plays an important role in tumour immune surveillance. Head and neck squamous cell carcinoma patients are often immune…”
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Allogeneic NK cells induce the in vitro activation of monocyte-derived and conventional type-2 dendritic cells and trigger an inflammatory response under cancer-associated conditions by Toffoli, E C, van Vliet, A A, Forbes, C, Arns, A J, Verheul, H W M, Tuynman, J, van der Vliet, H J, Spanholtz, J, de Gruijl, T D

“…Natural killer (NK) cells are innate lymphocytes capable to recognize and kill virus-infected and cancer cells. In the past years, the use of allogeneic NK…”
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Vaccination of chronic myeloid leukemia patients with autologous in vitro cultured leukemic dendritic cells by Ossenkoppele, G J, Stam, A G M, Westers, T M, de Gruijl, T D, Janssen, J J W M, van de Loosdrecht, A A, Scheper, R J

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4-1BB-mediated expansion affords superior detection of in vivo primed effector memory CD8+ T cells from melanoma sentinel lymph nodes by Sluijter, B.J.R, van den Hout, M.F.C.M, Stam, A.G.M, Lougheed, S.M, Suhoski, M.M, van den Eertwegh, A.J.M, van den Tol, M.P, van Leeuwen, P.A.M, Meijer, S, Scheper, R.J, June, C.H, de Gruijl, T.D, Santegoets, S.J.A.M

“…Abstract We have been studying the re-activation of tumor-associated antigen (TAA)-specific CD8+ T cells in sentinel lymph nodes (SLN) of melanoma patients…”
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Extended neoadjuvant chemotherapy in locally advanced breast cancer combined with GM-CSF: effect on tumour-draining lymph node dendritic cells by Pinedo, H.M, Buter, J, Luykx-de Bakker, S.A, Pohlmann, P.R, van Hensbergen, Y, Heideman, D.A.M, van Diest, P.J, de Gruijl, T.D, van der Wall, E

“…The effect of long-term administration of granulocyte-macrophage colony-stimulating factor (GM-CSF) on dendritic cell (DC) activation and survival in patients…”
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TNF-alpha receptor 1 expression on acute myeloid leukemic blasts predicts differentiation into leukemic dendritic cells by Houtenbos, I, Westers, T M, de Gruijl, T D, Scheper, R J, Ossenkoppele, G J, van de Loosdrecht, A A

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Differential T helper cell responses to human papillomavirus type 16 E7 related to viral clearance or persistence in patients with cervical neoplasia : A longitudinal study by DE GRUIJL, T. D, BONTKES, H. J, MEIJER, C. J. L. M, SCHEPER, R. J, WALBOOMERS, J. M. M, STUKART, M. J, DOEKHIE, F. S, REMMINK, A. J, HELMERHORST, T. J. M, VERHEIJEN, R. H. M, DUGGAN-KEEN, M. F, STERN, P. L

“…T-cell-mediated immune responses against oncogenic human papillomaviruses (HPVs) are believed to play a role in the prevention of cervical carcinogenesis. The…”
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Human natural killer T cells acquire a memory-activated phenotype before birth by van der Vliet, Hans J.J., Nishi, Nobusuke, de Gruijl, Tanja D., von Blomberg, B. Mary E., van den Eertwegh, Alfons J.M., Pinedo, Herbert M., Giaccone, Giuseppe, Scheper, Rik J.

“…Natural killer T (NKT) cells have recently been shown to play an important role in the rejection of malignant tumors and in the regulation of autoimmune…”
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Differences in cytokine mRNA profiles between premalignant and malignant lesions of the uterine cervix by de Gruijl, T.D, Bontkes, H.J, van den Muysenberg, A.J.C, van Oostveen, J.W, Stukart, M.J, Verheijen, R.H.M, van der Vange, N, Snijders, P.J.F, Meijer, C.J.L.M, Walboomers, J.M.M, Scheper, R.J

“…The aim of this study was to assess the expression of cytokine transcripts, reflecting the type of ongoing immune responses at the site of human papillomavirus…”
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Pre-treatment tumor-infiltrating T cells influence response to neoadjuvant chemoradiotherapy in esophageal adenocarcinoma by Goedegebuure, R.S.A., Harrasser, M., de Klerk, L.K., van Schooten, T.S., van Grieken, N.C.T., Eken, M., Grifhorst, M.S., Pocorni, N., Jordanova, E.S., van Berge Henegouwen, M.I., Pouw, R.E., Verheul, H.M.W., van der Vliet, J.J., van Laarhoven, H.W.M., Thijssen, V.L.J.L, Bass, A.J., De Gruijl, T.D., Derks, S.

“…Esophageal adenocarcinoma (EAC) is a disease with dismal treatment outcomes. Response to neoadjuvant chemoradiation (CRT) varies greatly. Although the…”
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Absence of Granzyme B positive tumour-infiltrating lymphocytes in primary melanoma excisional biopsies is strongly associated with the presence of sentinel lymph node metastasis by van Houdt, I S, Sluijter, B J R, van Leeuwen, P A M, Moesbergen, L M, Hooijberg, E, Meijer, C J L M, de Gruijl, T D, Oudejans, J J, Boven, E

“…Sentinel Lymph Node (SLN) status is strongly related to clinical outcome in melanoma patients. In this study we investigated the possible association between…”
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CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation by STAM, A. G. M, SANTEGOETS, S. J. A. M, SCHEPER, R. J, DE GRUIJL, T. D, WESTERS, T. M, SOMBROEK, C. C, JANSSEN, J. J. W. M, TILLMAN, B. W, VAN DE LOOSDRECHT, A. A, PINEDO, H. M, CURIEL, D. T, OSSENKOPPELE, G. J

“…Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show…”
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Assessment of cytotoxic T-lymphocyte phenotype using the specific markers granzyme B and TIA-1 in cervical neoplastic lesions by BONTKES, H. J, DE GRUIJL, T. D, WALBOOMERS, J. M. M, VAN DEN MUYSENBERG, A. J. C, GUNTHER, A. W, SCHEPER, R. J, MEIJER, C. J. L. M, KUMMER, J. A

“…Cervical carcinomas are closely associated with high-risk human papillomavirus (HPV) types and are preceded by cervical intraepithelial neoplasia (CIN). Most…”
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Expression of CD3-ζ on T-cells in primary cervical carcinoma and in metastasis-positive and -negative pelvic lymph nodes by DE GRUIJL, T. D, BONTKES, H. J, VAN DE VANGE, N, SCHEPER, R. J, PECCATORI, F, GALLEE, M. P. W, HELMERHORST, T. J. M, VERHEIJEN, R. H. M, AARBIOU, J, MULDER, W. M. C, WALBOOMERS, J. M. M, MEIJER, C. J. L. M

“…Lymphocytic infiltrate is often present in cervical cancer lesions, possibly reflecting an ongoing, but ineffective, immune response to the tumour. Recently,…”
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