Search Results - "Gruhn, Wolfram H."

Single-cell roadmap of human gonadal development by Garcia-Alonso, Luz, Lorenzi, Valentina, Mazzeo, Cecilia Icoresi, Alves-Lopes, João Pedro, Roberts, Kenny, Sancho-Serra, Carmen, Engelbert, Justin, Marečková, Magda, Gruhn, Wolfram H., Botting, Rachel A., Li, Tong, Crespo, Berta, van Dongen, Stijn, Kiselev, Vladimir Yu, Prigmore, Elena, Herbert, Mary, Moffett, Ashley, Chédotal, Alain, Bayraktar, Omer Ali, Surani, Azim, Haniffa, Muzlifah, Vento-Tormo, Roser

“…Gonadal development is a complex process that involves sex determination followed by divergent maturation into either testes or ovaries 1 . Historically,…”
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A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons by Sybirna, Anastasiya, Tang, Walfred W. C., Pierson Smela, Merrick, Dietmann, Sabine, Gruhn, Wolfram H., Brosh, Ran, Surani, M. Azim

“…PRDM14 is a crucial regulator of mouse primordial germ cells (mPGCs), epigenetic reprogramming and pluripotency, but its role in the evolutionarily divergent…”
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GADD45G Functions in Male Sex Determination by Promoting p38 Signaling and Sry Expression by Gierl, Mathias S., Gruhn, Wolfram H., von Seggern, Annika, Maltry, Nicole, Niehrs, Christof

“…Male sex determination in mammals is induced by Sry, a gene whose regulation is poorly understood. Here we show that mice mutant for the stress-response gene…”
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Targeted DamID reveals differential binding of mammalian pluripotency factors by Cheetham, Seth W, Gruhn, Wolfram H, van den Ameele, Jelle, Krautz, Robert, Southall, Tony D, Kobayashi, Toshihiro, Surani, M Azim, Brand, Andrea H

“…The precise control of gene expression by transcription factor networks is crucial to organismal development. The predominant approach for mapping…”
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Specification of human germ cell fate with enhanced progression capability supported by hindgut organoids by Alves-Lopes, João Pedro, Wong, Frederick C.K., Tang, Walfred W.C., Gruhn, Wolfram H., Ramakrishna, Navin B., Jowett, Geraldine M., Jahnukainen, Kirsi, Surani, M. Azim

“…Human primordial germ cells (hPGCs), the precursors of sperm and eggs, are specified during weeks 2−3 after fertilization. Few studies on ex vivo and in vitro…”
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Metabolic regulation of pluripotency and germ cell fate through α‐ketoglutarate by Tischler, Julia, Gruhn, Wolfram H, Reid, John, Allgeyer, Edward, Buettner, Florian, Marr, Carsten, Theis, Fabian, Simons, Ben D, Wernisch, Lorenz, Surani, M Azim

“…An intricate link is becoming apparent between metabolism and cellular identities. Here, we explore the basis for such a link in an in vitro model for early…”
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Generation of Primordial Germ Cell-like Cells on Small and Large Scales by Gruhn, Wolfram H, Günesdogan, Ufuk

“…The specification and development of germ cells to gametes is a unique process, which is of great biological and clinical relevance. In mammals, the founding…”
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Sequential enhancer state remodelling defines human germline competence and specification by Tang, Walfred W. C., Castillo-Venzor, Aracely, Gruhn, Wolfram H., Kobayashi, Toshihiro, Penfold, Christopher A., Morgan, Michael D., Sun, Dawei, Irie, Naoko, Surani, M. Azim

“…Germline–soma segregation is a fundamental event during mammalian embryonic development. Here we establish the epigenetic principles of human primordial germ…”
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Gadd45α modulates aversive learning through post‐transcriptional regulation of memory‐related mRNAs by Aparisi Rey, Alejandro, Karaulanov, Emil, Sharopov, Salim, Arab, Khelifa, Schäfer, Andrea, Gierl, Mathias, Guggenhuber, Stephan, Brandes, Caroline, Pennella, Luigi, Gruhn, Wolfram H, Jelinek, Ruth, Maul, Christina, Conrad, Andrea, Kilb, Werner, Luhmann, Heiko J, Niehrs, Christof, Lutz, Beat

“…Learning is essential for survival and is controlled by complex molecular mechanisms including regulation of newly synthesized mRNAs that are required to…”
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Epigenetic resetting in the human germ line entails histone modification remodeling by Gruhn, Wolfram H, Tang, Walfred W C, Dietmann, Sabine, Alves-Lopes, João P, Penfold, Christopher A, Wong, Frederick C K, Ramakrishna, Navin B, Surani, M Azim

“…Epigenetic resetting in the mammalian germ line entails acute DNA demethylation, which lays the foundation for gametogenesis, totipotency, and embryonic…”
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Gadd45α modulates aversive learning through post‐transcriptional regulation of memory‐related mRNA s by Aparisi Rey, Alejandro, Karaulanov, Emil, Sharopov, Salim, Arab, Khelifa, Schäfer, Andrea, Gierl, Mathias, Guggenhuber, Stephan, Brandes, Caroline, Pennella, Luigi, Gruhn, Wolfram H, Jelinek, Ruth, Maul, Christina, Conrad, Andrea, Kilb, Werner, Luhmann, Heiko J, Niehrs, Christof, Lutz, Beat

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