Search Results - "Gruhlke, Martin C.H."

A Comparison of the Antibacterial and Antifungal Activities of Thiosulfinate Analogues of Allicin by Leontiev, Roman, Hohaus, Nils, Jacob, Claus, Gruhlke, Martin C. H., Slusarenko, Alan J.

“…Allicin (diallylthiosulfinate) is a defence molecule from garlic ( Allium sativum L.) with broad antimicrobial activities in the low µM range against…”
Get full text

The biology of reactive sulfur species (RSS) by Gruhlke, Martin C.H., Slusarenko, Alan J.

“…Sulfur is an essential and quantitatively important element for living organisms. Plants contain on average approximately 1 g S kg−1 dry weight (for comparison…”
Get full text

Effect of silver nanoparticles on the standard soil arthropod Folsomia candida (Collembola) and the eukaryote model organism Saccharomyces cerevisiae by Sillapawattana, Panwad, Gruhlke, Martin C. H., Schäffer, Andreas

“…Background Because of their antimicrobial properties, silver nanoparticles (AgNPs) have been widely used and have come into contact with the environment. In…”
Get full text

Investigation of the deposition behaviour and antibacterial effectivity of allicin aerosols and vapour using a lung model by Reiter, Jana, Borlinghaus, Jan, Dörner, Philipp, Schröder, Wolfgang, Gruhlke, Martin C H, Klaas, Michael, Slusarenko, Alan J

“…Allicin is a natural antibiotic produced by garlic as a defence against pathogens and pests. Due to the worldwide increase in antibiotic resistance, new…”
Get full text

Impact of allicin on macrophage activity by Haase, Hajo, Hieke, Nora, Plum, Laura M., Gruhlke, Martin C.H., Slusarenko, Alan J., Rink, Lothar

“…► Allicin showed comparable toxicity toward Escherichia coli and Raw 264.7 murine macrophages. ► In Raw 264.7, allicin inhibits NO production, but not…”
Get full text

Yeast Chemogenetic Screening as a Tool to Unravel  the Antifungal Mode of Action of Two Selected Selenocyanates by Sarfraz, Muhammad, Nasim, Muhammad Jawad, Jacob, Claus, Gruhlke, Martin C.H.

“…During recent decades, selenium-containing compounds, as with the chemically similar sulfur-containing compounds, have gained considerable interest as…”
Get full text

Effect of Prooxidative Natural Products: Comparison of the OSI1 (YKL071w) Promoter Luciferase Construct from Yeast with an Nrf2/Keap Reporter System by Schlembach, Ivan, Uebachs, Andreas, Caspers, Tim, Fragoulis, Athanassios, Slusarenko, Alan J., Gruhlke, Martin C. H.

“…The oxidative stress response (OSR) in yeast is under the control of oxidation-sensitive cysteines in the Yap1p transcription factor, and fusion of the…”
Get full text

The human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects by Gruhlke, Martin C.H., Antelmann, Haike, Bernhardt, Jörg, Kloubert, Veronika, Rink, Lothar, Slusarenko, Alan J.

“…A single clove of edible garlic (Allium sativum L.) of about 10 g produces up to 5 mg of allicin (diallylthiosulfinate), a thiol-reactive sulfur-containing…”
Get full text

Allicin: chemistry and biological properties by Borlinghaus, Jan, Albrecht, Frank, Gruhlke, Martin C H, Nwachukwu, Ifeanyi D, Slusarenko, Alan J

“…Allicin (diallylthiosulfinate) is a defence molecule from garlic (Allium sativum L.) with a broad range of biological activities. Allicin is produced upon…”
Get full text

Allicin, the Odor of Freshly Crushed Garlic: A Review of Recent Progress in Understanding Allicin's Effects on Cells by Borlinghaus, Jan, Foerster Née Reiter, Jana, Kappler, Ulrike, Antelmann, Haike, Noll, Ulrike, Gruhlke, Martin C H, Slusarenko, Alan J

“…The volatile organic sulfur compound allicin (diallyl thiosulfinate) is produced as a defense substance when garlic ( ) tissues are damaged, for example by the…”
Get full text

Allicin, a Potent New Ornithine Decarboxylase Inhibitor in Neuroblastoma Cells by Schultz, Chad R, Gruhlke, Martin C. H, Slusarenko, Alan J, Bachmann, André S

“…The natural product allicin is a reactive sulfur species (RSS) from garlic (Allium sativum L.). Neuroblastoma (NB) is an early childhood cancer arising from…”
Get full text

Combating Black Fungus: Using Allicin as a Potent Antifungal Agent against Mucorales by Schier, Christina, Gruhlke, Martin C H, Reucher, Georg, Slusarenko, Alan J, Rink, Lothar

“…Invasive fungal (IF) diseases are a leading global cause of mortality, particularly among immunocompromised individuals. The SARS-CoV-2 pandemic further…”
Get full text

Yap1p, the central regulator of the S. cerevisiae oxidative stress response, is activated by allicin, a natural oxidant and defence substance of garlic by Gruhlke, Martin C.H., Schlembach, Ivan, Leontiev, Roman, Uebachs, Andreas, Gollwitzer, Peter U.G., Weiss, Alexander, Delaunay, Agnes, Toledano, Michel, Slusarenko, Alan J.

“…Allicin is a thiol-reactive sulfur-containing natural product from garlic with a broad range of antimicrobial effects against prokaryotes and eukaryotes…”
Get full text

The defense substance allicin from garlic permeabilizes membranes of Beta vulgaris, Rhoeo discolor, Chara corallina and artificial lipid bilayers by Gruhlke, Martin C H, Hemmis, Birgit, Noll, Ulrike, Wagner, Richard, Lühring, Hinrich, Slusarenko, Alan J

“…Allicin (diallylthiosulfinate) is the major volatile- and antimicrobial substance produced by garlic cells upon wounding. We tested the hypothesis that allicin…”
Get full text

The Effects of Allicin, a Reactive Sulfur Species from Garlic, on a Selection of Mammalian Cell Lines by Gruhlke, Martin C H, Nicco, Carole, Batteux, Frederic, Slusarenko, Alan J

“…Garlic ( L.) has been used as a spice and medicinal plant since ancient times. Garlic produces the thiol-reactive defence substance, allicin, upon wounding…”
Get full text

Allicin disrupts the cell's electrochemical potential and induces apoptosis in yeast by Gruhlke, Martin C.H., Portz, Daniela, Stitz, Michael, Anwar, Awais, Schneider, Thomas, Jacob, Claus, Schlaich, Nikolaus L., Slusarenko, Alan J.

“…The volatile substance allicin gives crushed garlic ( Allium sativum) its characteristic odor and is a pro-oxidant that undergoes thiol–disulfide exchange…”
Get full text

Allicin as a Volatile or Nebulisable Antimycotic for the Treatment of Pulmonary Mycoses: In Vitro Studies Using a Lung Flow Test Rig by Schier, Christina, Foerster (née Reiter), Jana, Heupel, Monika, Dörner, Philipp, Klaas, Michael, Schröder, Wolfgang, Rink, Lothar, Slusarenko, Alan J., Gruhlke, Martin C. H.

“…Fungal infections of the lung are an increasing problem worldwide and the search for novel therapeutic agents is a current challenge due to emerging resistance…”
Get full text

The Chemistry of Alliums by Gruhlke, Martin C H, Slusarenko, Alan J

“…Physiologically active sulfur-containing compounds produced by Allium spp. have long fascinated chemists, biochemists, and biologists.[...]…”
Get full text

Editorial: Redox-Active Molecules as Antimicrobials: Mechanisms and Resistance by Kim, Jong H., Cheng, Luisa W., Land, Kirkwood M., Gruhlke, Martin C. H.

Get full text

Genetic and molecular characterization of multicomponent resistance of Pseudomonas against allicin by Borlinghaus, Jan, Bolger, Anthony, Schier, Christina, Vogel, Alexander, Usadel, Björn, Gruhlke, Martin Ch, Slusarenko, Alan J

“…The common foodstuff garlic produces the potent antibiotic defense substance allicin after tissue damage. Allicin is a redox toxin that oxidizes glutathione…”
Get full text