Search Results - "Gruhlke, Martin"

Allicin: chemistry and biological properties by Borlinghaus, Jan, Albrecht, Frank, Gruhlke, Martin C H, Nwachukwu, Ifeanyi D, Slusarenko, Alan J

“…Allicin (diallylthiosulfinate) is a defence molecule from garlic (Allium sativum L.) with a broad range of biological activities. Allicin is produced upon…”
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A Comparison of the Antibacterial and Antifungal Activities of Thiosulfinate Analogues of Allicin by Leontiev, Roman, Hohaus, Nils, Jacob, Claus, Gruhlke, Martin C. H., Slusarenko, Alan J.

“…Allicin (diallylthiosulfinate) is a defence molecule from garlic ( Allium sativum L.) with broad antimicrobial activities in the low µM range against…”
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The biology of reactive sulfur species (RSS) by Gruhlke, Martin C.H., Slusarenko, Alan J.

“…Sulfur is an essential and quantitatively important element for living organisms. Plants contain on average approximately 1 g S kg−1 dry weight (for comparison…”
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Allicin, the Odor of Freshly Crushed Garlic: A Review of Recent Progress in Understanding Allicin's Effects on Cells by Borlinghaus, Jan, Foerster Née Reiter, Jana, Kappler, Ulrike, Antelmann, Haike, Noll, Ulrike, Gruhlke, Martin C H, Slusarenko, Alan J

“…The volatile organic sulfur compound allicin (diallyl thiosulfinate) is produced as a defense substance when garlic ( ) tissues are damaged, for example by the…”
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The human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects by Gruhlke, Martin C.H., Antelmann, Haike, Bernhardt, Jörg, Kloubert, Veronika, Rink, Lothar, Slusarenko, Alan J.

“…A single clove of edible garlic (Allium sativum L.) of about 10 g produces up to 5 mg of allicin (diallylthiosulfinate), a thiol-reactive sulfur-containing…”
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Allicin, a Potent New Ornithine Decarboxylase Inhibitor in Neuroblastoma Cells by Schultz, Chad R, Gruhlke, Martin C. H, Slusarenko, Alan J, Bachmann, André S

“…The natural product allicin is a reactive sulfur species (RSS) from garlic (Allium sativum L.). Neuroblastoma (NB) is an early childhood cancer arising from…”
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Seeing the smell of garlic: Detection of gas phase volatiles from crushed garlic (Allium sativum), onion (Allium cepa), ramsons (Allium ursinum) and human garlic breath using SESI-Orbitrap MS by Mengers, Hendrik G., Schier, Christina, Zimmermann, Martin, C. H. Gruhlke, Martin, Block, Eric, Blank, Lars M., Slusarenko, Alan J.

“…[Display omitted] •Secondary electrospray ionisation (SESI) implemented for volatile sulfur compounds.•Intact allicin measured in vapour from a solution of…”
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Combating Black Fungus: Using Allicin as a Potent Antifungal Agent against Mucorales by Schier, Christina, Gruhlke, Martin C H, Reucher, Georg, Slusarenko, Alan J, Rink, Lothar

“…Invasive fungal (IF) diseases are a leading global cause of mortality, particularly among immunocompromised individuals. The SARS-CoV-2 pandemic further…”
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The Effects of Allicin, a Reactive Sulfur Species from Garlic, on a Selection of Mammalian Cell Lines by Gruhlke, Martin C H, Nicco, Carole, Batteux, Frederic, Slusarenko, Alan J

“…Garlic ( L.) has been used as a spice and medicinal plant since ancient times. Garlic produces the thiol-reactive defence substance, allicin, upon wounding…”
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Diallylthiosulfinate (Allicin), a Volatile Antimicrobial from Garlic (Allium sativum), Kills Human Lung Pathogenic Bacteria, Including MDR Strains, as a Vapor by Reiter, Jana, Levina, Natalja, van der Linden, Mark, Gruhlke, Martin, Martin, Christian, Slusarenko, Alan J

“…Garlic ( ) has potent antimicrobial activity due to allicin (diallylthiosulfinate) synthesized by enzyme catalysis in damaged garlic tissues. Allicin gives…”
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The Chemistry of Alliums by Gruhlke, Martin C H, Slusarenko, Alan J

“…Physiologically active sulfur-containing compounds produced by Allium spp. have long fascinated chemists, biochemists, and biologists.[...]…”
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Yap1p, the central regulator of the S. cerevisiae oxidative stress response, is activated by allicin, a natural oxidant and defence substance of garlic by Gruhlke, Martin C.H., Schlembach, Ivan, Leontiev, Roman, Uebachs, Andreas, Gollwitzer, Peter U.G., Weiss, Alexander, Delaunay, Agnes, Toledano, Michel, Slusarenko, Alan J.

“…Allicin is a thiol-reactive sulfur-containing natural product from garlic with a broad range of antimicrobial effects against prokaryotes and eukaryotes…”
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Allicin disrupts the cell's electrochemical potential and induces apoptosis in yeast by Gruhlke, Martin C.H., Portz, Daniela, Stitz, Michael, Anwar, Awais, Schneider, Thomas, Jacob, Claus, Schlaich, Nikolaus L., Slusarenko, Alan J.

“…The volatile substance allicin gives crushed garlic ( Allium sativum) its characteristic odor and is a pro-oxidant that undergoes thiol–disulfide exchange…”
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Investigation of the deposition behaviour and antibacterial effectivity of allicin aerosols and vapour using a lung model by Reiter, Jana, Borlinghaus, Jan, Dörner, Philipp, Schröder, Wolfgang, Gruhlke, Martin C H, Klaas, Michael, Slusarenko, Alan J

“…Allicin is a natural antibiotic produced by garlic as a defence against pathogens and pests. Due to the worldwide increase in antibiotic resistance, new…”
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Allicin as a Volatile or Nebulisable Antimycotic for the Treatment of Pulmonary Mycoses: In Vitro Studies Using a Lung Flow Test Rig by Schier, Christina, Foerster (née Reiter), Jana, Heupel, Monika, Dörner, Philipp, Klaas, Michael, Schröder, Wolfgang, Rink, Lothar, Slusarenko, Alan J., Gruhlke, Martin C. H.

“…Fungal infections of the lung are an increasing problem worldwide and the search for novel therapeutic agents is a current challenge due to emerging resistance…”
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Impact of allicin on macrophage activity by Haase, Hajo, Hieke, Nora, Plum, Laura M., Gruhlke, Martin C.H., Slusarenko, Alan J., Rink, Lothar

“…► Allicin showed comparable toxicity toward Escherichia coli and Raw 264.7 murine macrophages. ► In Raw 264.7, allicin inhibits NO production, but not…”
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The defense substance allicin from garlic permeabilizes membranes of Beta vulgaris, Rhoeo discolor, Chara corallina and artificial lipid bilayers by Gruhlke, Martin C H, Hemmis, Birgit, Noll, Ulrike, Wagner, Richard, Lühring, Hinrich, Slusarenko, Alan J

“…Allicin (diallylthiosulfinate) is the major volatile- and antimicrobial substance produced by garlic cells upon wounding. We tested the hypothesis that allicin…”
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Editorial: Redox-Active Molecules as Antimicrobials: Mechanisms and Resistance by Kim, Jong H., Cheng, Luisa W., Land, Kirkwood M., Gruhlke, Martin C. H.

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Efficacy of Allicin against Plant Pathogenic Fungi and Unveiling the Underlying Mode of Action Employing Yeast Based Chemogenetic Profiling Approach by Sarfraz, Muhammad, Nasim, Muhammad Jawad, Jacob, Claus, Gruhlke, Martin C. H.

“…Allicin (diallylthiosulfinate) is the principal organosulfur compound present in freshly damaged garlic tissue which exhibits a wide range of biological…”
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S -allylmercaptoglutathione Is a Substrate for Glutathione Reductase (E.C. 1.8.1.7) from Yeast ( Saccharomyces cerevisiae ) by Horn, Tobias, Bettray, Wolfgang, Slusarenko, Alan J, Gruhlke, Martin C H

“…Allicin (diallylthiosulfinate) is a potent thiol reagent and natural defense substance produced by garlic ( ) tissues when damaged. Allicin acts as a redox…”
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