Search Results - "Grudzinski, J"

Beyond the margins: real-time detection of cancer using targeted fluorophores by Zhang, Ray R., Schroeder, Alexandra B., Grudzinski, Joseph J., Rosenthal, Eben L., Warram, Jason M., Pinchuk, Anatoly N., Eliceiri, Kevin W., Kuo, John S., Weichert, Jamey P.

“…Key Points Fluorescence imaging can transform the way surgeries are performed, through the intraoperative identification of vital structures, lymph nodes and…”
Get full text

Development and Validation of RAPID: A Patient-Specific Monte Carlo Three-Dimensional Internal Dosimetry Platform by Besemer, Abigail E, Yang, You Ming, Grudzinski, Joseph J, Hall, Lance T, Bednarz, Bryan P

“…This work describes the development and validation of a patient-specific Monte Carlo internal dosimetry platform called RAPID (Radiopharmaceutical Assessment…”
Get more information

Software Architecture and Hardware Organization in Mu2e Solenoid Field Mapping System by Nogiec, J. M., Akella, P., Feher, S., Grudzinski, J., Strauss, T., Talaga, R. L., Xia, L.

“…The Mu2e field mapping system is designed to produce high accuracy field maps of the detector solenoid used in the experiment. The data acquisition system is…”
Get full text

Developments in Combining Targeted Radionuclide Therapies and Immunotherapies for Cancer Treatment by Kerr, Caroline P, Grudzinski, Joseph J, Nguyen, Thanh Phuong, Hernandez, Reinier, Weichert, Jamey P, Morris, Zachary S

“…Targeted radionuclide therapy (TRT) and immunotherapy are rapidly growing classes of cancer treatments. Basic, translational, and clinical research are now…”
Get full text

Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy by Jagodinsky, Justin C, Jin, Won Jong, Bates, Amber M, Hernandez, Reinier, Grudzinski, Joseph J, Marsh, Ian R, Chakravarty, Ishan, Arthur, Ian S, Zangl, Luke M, Brown, Ryan J, Nystuen, Erin J, Emma, Sarah E, Kerr, Caroline, Carlson, Peter M, Sriramaneni, Raghava N, Engle, Jonathan W, Aluicio-Sarduy, Eduardo, Barnhart, Todd E, Le, Trang, Kim, KyungMann, Bednarz, Bryan P, Weichert, Jamey P, Patel, Ravi B, Morris, Zachary S

“…Clinical interest in combining targeted radionuclide therapies (TRT) with immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1…”
Get full text

Image-Based Dosimetry in Dogs and Cross-Reactivity with Human Tissues of IGF2R-Targeting Human Antibody by Allen, Kevin J H, Kwon, Ohyun, Hutcheson, Matthew R, Grudzinski, Joseph J, Cain, Stuart M, Cruz, Frederic A, Vinayakamoorthy, Remitha M, Sun, Ying S, Fairley, Lindsay, Prabaharan, Chandra B, Dickinson, Ryan, MacDonald-Dickinson, Valerie, Uppalapati, Maruti, Bednarz, Bryan P, Dadachova, Ekaterina

“…Osteosarcoma (OS) represents the most common primary bone tumor in humans and in companion dogs, being practically phenotypically identical. There is a need…”
Get full text

Clinical Imaging and Dosimetry of a Pan-Cancer Targeting Alkylphosphocholine Analog, [124I]I-NM404 by Grudzinski, Joseph J., Hall, Lance T., Cho, Steve, Liu, Glenn, Traynor, Anne, Lee, Matthew H., Longino, Marc, Pinchuk, Anatoly, Jaskowiak, Christine, Bednarz, Bryan, Weichert, Jamey, Kuo, John S.

“…The purpose of this study was to assess organ dosimetry and clinical use of [124I]I-NM404, a radiotheranostic alkylphosphocholine (APC) analog, for accurate…”
Get full text

SU‐F‐500‐01: Towards Personalized Dosimetry Using Diapeutic Radiopharmaceuticals by Besemer, A, Grudzinski, J, Titz, B, Wickre, P, Hall, L, Weichert, J, Bednarz, B

“…Purpose: he efficacy of targeted radionuclide therapy (TRT) depends on the ability to accurately characterize the absorbed dose distribution within tumors as…”
Get full text

A phase 1 study of 131I-CLR1404 in patients with relapsed or refractory advanced solid tumors: dosimetry, biodistribution, pharmacokinetics, and safety by Grudzinski, Joseph J, Titz, Benjamin, Kozak, Kevin, Clarke, William, Allen, Ernest, Trembath, LisaAnn, Stabin, Michael, Marshall, John, Cho, Steve Y, Wong, Terence Z, Mortimer, Joanne, Weichert, Jamey P

“…(131)I-CLR1404 is a small molecule that combines a tumor-targeting moiety with a therapeutic radioisotope. The primary aim of this phase 1 study was to…”
Get full text

SU‐FF‐T‐458: Complementing Targeted Radionuclide Therapy with External Beam Radiotherapy: Planning Study by Grudzinski, J, Bowen, S, Tome, W, Weichert, J, Jeraj, R

“…Purpose: Combining intensity modulated radiotherapy (IMRT) with targeted radionuclide therapy (TRT) can reduce local radiation toxicity. TRT systemically…”
Get full text

SU‐GG‐I‐139: Improving the Efficacy of a Radionuclide Targeting Agent by Simulating Its Pharmacokinetics by Grudzinski, J, Weichert, J, Jeraj, R

“…Purpose: Radionuclide therapy aims to deliver therapeutic doses to a tumor while sparing normal tissues by selective retention of a radionuclide carrying agent…”
Get full text

Voxel-Level Dosimetry for Combined Iodine 131 Radiopharmaceutical Therapy and External Beam Radiation Therapy Treatment Paradigms for Head and Neck Cancer by Adam, David P., Grudzinski, Joseph J., Marsh, Ian R., Hill, Patrick M., Cho, Steve Y., Bradshaw, Tyler J., Longcor, Jarrod, Burr, Adam, Bruce, Justine Y., Harari, Paul M., Bednarz, Bryan P.

“…Targeted radiopharmaceutical therapy (RPT) in combination with external beam radiation therapy (EBRT) shows promise as a method to increase tumor control and…”
Get full text

Dosimetric effectiveness of targeted radionuclide therapy based on a pharmacokinetic landscape by Grudzinski, Joseph J, Burnette, Ronald R, Weichert, Jamey P, Jeraj, Robert

“…Assessment of targeted radionuclide therapy (TRT) agent effectiveness based on its pharmacokinetic (PK) properties could provide means to expedited agent…”
Get more information

SU‐FF‐I‐119: Novel MicroCT Imaging Techniques for In Vivo Quantification of Vascular Volume in Murine Tumor Models by Nyflot, M, Grudzinski, J, Jeraj, R

“…Purpose: Growing interest in angiogenesis and anti‐angiogenic tumor therapy has created a demand for vascular imaging techniques. This work describes a method…”
Get full text

TU‐E‐141‐08: Dosimetric Impact of Partial Volume Correction On PET‐Based Targeted Radionuclide Therapy Planning by Titz, B, Grudzinski, JJ, Barbee, DL, Weichert, JP

“…Purpose: Partial volume effects have been shown to introduce a significant error in positron emission tomography (PET) quantitation. In this study, we…”
Get full text

Preclinical Characterization of 86/90 Y-NM600 in a Variety of Murine and Human Cancer Tumor Models by Grudzinski, Joseph J, Hernandez, Reinier, Marsh, Ian, Patel, Ravi B, Aluicio-Sarduy, Eduardo, Engle, Jon, Morris, Zachary, Bednarz, Bryan, Weichert, Jamey

“…We characterize the in vivo biodistribution and tumor selectivity of Y-NM600, a theranostic alkylphosphocholine radiometal chelate with broad tumor…”
Get full text

Validation of Monte Carlo 131 I radiopharmaceutical dosimetry workflow using a 3D-printed anthropomorphic head and neck phantom by Adam, David P, Grudzinski, Joseph J, Bormett, Ian, Cox, Benjamin L, Marsh, Ian R, Bradshaw, Tyler J, Harari, Paul M, Bednarz, Bryan P

“…Approximately 50% of head and neck cancer (HNC) patients will experience loco-regional disease recurrence following initial courses of therapy. Retreatment…”
Get full text

Patient specific treatment planning for systemically administered radiopharmaceuticals using PET/CT and Monte Carlo simulation by Grudzinski, J.J., Yoriyaz, H., DeLuca, P.M., Weichert, J.P.

“…The efficacy of systemically administered radiopharmaceuticals depends on the physiological path of the targeting molecule and the physical characteristics of…”
Get full text

Low-Dose Radiation Potentiates the Propagation of Anti-Tumor Immunity against Melanoma Tumor in the Brain after In Situ Vaccination at a Tumor outside the Brain by Clark, Paul A., Sriramaneni, Raghava N., Bates, Amber M., Jin, Won Jong, Jagodinsky, Justin C., Hernandez, Reinier, Le, Trang, Jeffery, Justin J., Marsh, Ian R., Grudzinski, Joseph J., Aluicio-Sarduy, Eduardo, Barnhart, Todd E., Anderson, Bryce R., Chakravarty, Ishan, Arthur, Ian S., Kim, KyungMann, Engle, Jonathan W., Bednarz, Bryan P., Weichert, Jamey P., Morris, Zachary S.

“…Brain metastases develop in over 60% of advanced melanoma patients and negatively impact quality of life and prognosis. In a murine melanoma model, we…”
Get full text

177Lu-NM600 Targeted Radionuclide Therapy Extends Survival in Syngeneic Murine Models of Triple-Negative Breast Cancer by Hernandez, Reinier, Grudzinski, Joseph J, Aluicio-Sarduy, Eduardo, Massey, Christopher F, Pinchuk, Anatoly N, Bitton, Ariana N, Patel, Ravi, Zhang, Ray, Rao, Aakarsha V, Iyer, Gopal, Engle, Jonathan W, Weichert, Jamey P

“…There is a clinically unmet need for effective treatments for triple-negative breast cancer (TNBC), as it remains the most aggressive subtype of breast cancer…”
Get full text