Search Results - "Gruber, Michael L."

Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival by Narayana, Ashwatha, Kelly, Patrick, Golfinos, John, Parker, Erik, Johnson, Glyn, Knopp, Edmond, Zagzag, David, Fischer, Ingeborg, Raza, Shahzad, Medabalmi, Praveen, Eagan, Patricia, Gruber, Michael L

“…Antiangiogenic agents have recently shown impressive radiological responses in high-grade glioma. However, it is not clear if the responses are related to…”
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A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma by NARAYANA, Ashwatha, GRUBER, Deborah, KUNNAKKAT, Saroj, GOLFINOS, John G, PARKER, Erik, RAZA, Shahzad, ZAGZAG, David, EAGAN, Patricia, GRUBER, Michael L

“…The presence of angiogenesis is a hallmark of glioblastoma (GBM). Vascular endothelial growth factor (VEGF), which drives angiogenesis, provides an additional…”
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Change in Pattern of Relapse After Antiangiogenic Therapy in High-Grade Glioma by Narayana, Ashwatha, M.D, Kunnakkat, Saroj D., M.S, Medabalmi, Praveen, M.P.H, Golfinos, John, M.D, Parker, Erik, M.D, Knopp, Edmond, M.D, Zagzag, David, M.D, Eagan, Patricia, R.N, Gruber, Deborah, M.D, Gruber, Michael L., M.D

“…Purpose Local recurrence is the dominant pattern of relapse in high-grade glioma (HGG) after conventional therapy. The recent use of antiangiogenic therapy has…”
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Feasibility of Using Bevacizumab With Radiation Therapy and Temozolomide in Newly Diagnosed High-Grade Glioma by Narayana, Ashwatha, M.D, Golfinos, John G., M.D, Fischer, Ingeborg, M.D, Raza, Shahzad, M.D, Kelly, Patrick, M.D, Parker, Erik, M.D, Knopp, Edmond A., M.D, Medabalmi, Praveen, M.P.H, Zagzag, David, M.D, Eagan, Patricia, R.N, Gruber, Michael L., M.D

“…Introduction Bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), has shown promise in the treatment of patients with…”
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Antiangiogenic therapy using bevacizumab in recurrent high-grade glioma: impact on local control and patient survival : Clinical article by NARAYANA, Ashwatha, KELLY, Patrick, EAGAN, Patricia, GRUBER, Michael L, GOLFINOS, John, PARKER, Erik, JOHNSON, Glyn, KNOPP, Edmond, ZAGZAG, David, FISCHER, Ingeborg, RAZA, Shahzad, MEDABALMI, Praveen

“…Object Antiangiogenic agents have recently shown impressive radiological responses in high-grade glioma. However, it is not clear if the responses are related…”
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Gliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging by Law, Meng, Young, Robert J, Babb, James S, Peccerelli, Nicole, Chheang, Sophie, Gruber, Michael L, Miller, Douglas C, Golfinos, John G, Zagzag, David, Johnson, Glyn

“…To retrospectively determine whether relative cerebral blood volume (CBV) measurements can be used to predict clinical outcome in patients with high-grade…”
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Involved field radiation therapy after surgical resection of solitary brain metastases--mature results by Connolly, Eileen P, Mathew, Maya, Tam, Moses, King, Josephine Vera, Kunnakkat, Saroj D, Parker, Erik C, Golfinos, John G, Gruber, Michael L, Narayana, Ashwatha

“…Whole brain radiation therapy (WBRT) reduces local recurrence in patients after surgical resection of brain metastases without improving overall survival…”
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High-grade glioma before and after treatment with radiation and Avastin: initial observations by Fischer, Ingeborg, Cunliffe, Clare H, Bollo, Robert J, Raza, Shahzad, Monoky, David, Chiriboga, Luis, Parker, Erik C, Golfinos, John G, Kelly, Patrick J, Knopp, Edmond A, Gruber, Michael L, Zagzag, David, Narayana, Ashwatha

“…We evaluate the effects of adjuvant treatment with the angiogenesis inhibitor Avastin (bevacizumab) on pathological tissue specimens of high-grade glioma…”
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High cerebral blood volume in human gliomas predicts deletion of chromosome 1p: Preliminary results of molecular studies in gliomas with elevated perfusion by Law, Meng, Brodsky, Jennie E., Babb, James, Rosenblum, Marc, Miller, Douglas C., Zagzag, David, Gruber, Michael L., Johnson, Glyn

“…Purpose To determine if increased perfusion using dynamic susceptibility contrast perfusion MRI (DSC MRI) in gliomas may be predictive of 1p19q deletions. Loss…”
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Temozolomide in combination with irinotecan for treatment of recurrent malignant glioma by Gruber, Michael L, Buster, Ward P

“…The prognosis for patients with recurrent malignant glioma is poor. Both temozolomide and irinotecan have been shown to be active in this disease. A study was…”
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Phase II study of combination taxol and estramustine phosphate in the treatment of recurrent glioblastoma multiforme by ROSENTHAL, M. A, GRUBER, M. L, GLASS, J, NIRENBERG, A, FINLAY, J, HOCHSTER, H, MUGGIA, F. M

“…Taxol has activity in the treatment of high grade gliomas but estramustine phosphate (EMP) has not been used in this setting. In vitro data demonstrates that…”
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Dynamic Contrast-enhanced T2-weighted MR Imaging of Recurrent Malignant Gliomas Treated with Thalidomide and Carboplatin by Cha, Soonmee, Knopp, Edmond A, Johnson, Glyn, Litt, Andrew, Glass, Jon, Gruber, Michael L, Lu, Stanley, Zagzag, David

“…Dynamic, contrast-enhanced MR imaging has allowed quantitative assessment of cerebral blood volume (CBV) in brain tumors. The purpose of our study was to…”
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Preirradiation methotrexate chemotherapy of primary central nervous system lymphoma : long-term outcome by GLASS, J, GRUBER, M. L, CHER, L, HOCHBERG, F. H

“…The treatment of primary central nervous system lymphoma with chemotherapy prior to whole-brain radiation therapy (WBRT) has improved outcome considerably in…”
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A clinical trial of bevacizumab, temozolomide, and radiation for newly diagnosed glioblastoma: Clinical article by Narayana, Ashwatha, Gruber, Deborah, Kunnakkat, Saroj, Golfinos, John G., Parker, Erik, Raza, Shahzad, Zagzag, David, Eagan, Patricia, Gruber, Michael L.

“…Object The presence of angiogenesis is a hallmark of glioblastoma (GBM). Vascular endothelial growth factor (VEGF), which drives angiogenesis, provides an…”
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A phase II trial of lithium, bevacizumab, temozolomide, and radiation for newly diagnosed glioblastomas (GBM) by Narayana, Ashwatha, Tam, Moses M, Gruber, Deborah Beth, Golfinos, John, Parker, Erik, Zagzag, David, Gruber, Michael L.

“…Abstract only e13033 Background: Invasion is a dominant escape mechanism following angiogenic blockade in glioblastomas (GBM). Lithium has shown anti-invasive…”
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Comparative impact of treatment on clinical benefit in patients with glioblastoma (GBM) enrolled in the phase II trial of ICT-107 by Armstrong, Terri S., Wen, Patrick Y., Reardon, David A., Phuphanich, Surasak, Aiken, Robert, Landolfi, Joseph C., Curry, William T., Zhu, Jay-Jiguang, Glantz, Michael J., Peereboom, David M., Markert, James, LaRocca, Renato V., O'Rourke, Donald, Fink, Karen L., Kim, Lyndon J., Gruber, Michael L., Lesser, Glenn Jay, Pan, Edward, Kesari, Santosh, Yu, John

“…Abstract only…”
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A randomized, double-blind, placebo-controlled phase 2 trial of dendritic cell (DC) vaccination with ICT-107 in newly diagnosed glioblastoma (GBM) patients by Wen, Patrick Y., Reardon, David A., Phuphanich, Surasak, Aiken, Robert, Landolfi, Joseph C., Curry, William T., Zhu, Jay-Jiguang, Glantz, Michael J., Peereboom, David M., Markert, James, LaRocca, Renato V., O'Rourke, Donald, Fink, Karen L., Kim, Lyndon J., Gruber, Michael L., Lesser, Glenn Jay, Pan, Edward, Kesari, Santosh, Hawkins, Elma S., Yu, John

“…Abstract only…”
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Abstract 5336: Change in pattern of relapse following anti-angiogenic therapy in high grade gliomas by Narayana, Ashwatha, Kunnakkat, Saroj, Medabalmi, Praveen, Golfinos, John, Parker, Erik, Knopp, Edmond, Zagzag, David, Gruber, Deborah, Gruber, Michael L.

“…Abstract Purpose:. Local recurrence (LR) accounts for >90% at the time of relapse in high grade glioma (HGG) following conventional therapy. Anti-angiogenic…”
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A randomized, double‑blind, controlled phase IIb study of the safety and efficacy of ICT‑107 in newly diagnosed patients with glioblastoma multiforme following resection and chemoradiation by Hawkins, Elma S., Aiken, Robert, Chandler, James, Fink, Karen L., Glantz, Michael J., Grewal, Jai, Gruber, Michael L., Kesari, Santosh, Landolfi, Joseph C., LaRocca, Renato V., Lesser, Glenn Jay, Markert, James, Mayer, Tina M., O'Rourke, Donald, Peereboom, David M., Phuphanich, Surasak, Schiff, David, Sloan, Andrew E., Stea, Baldassarre, Zhu, Jay-Jiguang

“…Abstract only TPS2107 Background: Tumor stem cells have been correlated with recurrence and clinical outcome in glioblastoma multiforme (GBM). ICT‑107 is an…”
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Pathology with clinical correlations of primary central nervous system non-Hodgkin's lymphoma. The Massachusetts General Hospital experience 1958-1989 by Miller, D C, Hochberg, F H, Harris, N L, Gruber, M L, Louis, D N, Cohen, H

“…Primary central nervous system non-Hodgkin's lymphoma (NHL-CNS) is an enigmatic disease of uncertain origin. At the Massachusetts General Hospital, 104…”
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