Search Results - "Gruben, David"

Placebo-Controlled Trial of Tofacitinib Monotherapy in Rheumatoid Arthritis by Fleischmann, Roy, Kremer, Joel, Cush, John, Schulze-Koops, Hendrik, Connell, Carol A, Bradley, John D, Gruben, David, Wallenstein, Gene V, Zwillich, Samuel H, Kanik, Keith S

“…In a placebo-controlled trial, monotherapy with tofacitinib, an oral Janus kinase inhibitor, reduced the symptoms and signs of rheumatoid arthritis. Adverse…”
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Tofacitinib versus Methotrexate in Rheumatoid Arthritis by Lee, Eun Bong, Fleischmann, Roy, Hall, Stephen, Wilkinson, Bethanie, Bradley, John D, Gruben, David, Koncz, Tamas, Krishnaswami, Sriram, Wallenstein, Gene V, Zang, Chuanbo, Zwillich, Samuel H, van Vollenhoven, Ronald F

“…In patients with rheumatoid arthritis, tofacitinib was associated with greater reductions in signs and symptoms than methotrexate. Herpes zoster infections and…”
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Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial by Burmester, Gerd R, Prof, Blanco, Ricardo, MD, Charles-Schoeman, Christina, MD, Wollenhaupt, Jürgen, Prof, Zerbini, Cristiano, MD, Benda, Birgitta, MD, Gruben, David, PhD, Wallenstein, Gene, PhD, Krishnaswami, Sriram, PhD, Zwillich, Samuel H, MD, Koncz, Tamas, MD, Soma, Koshika, MD, Bradley, John, MD, Mebus, Charles, PhD

“…Summary Background Rheumatoid arthritis is a heterogeneous chronic disease, and no therapeutic agent has been identified which is universally and persistently…”
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Safety and Efficacy of Tofacitinib, an Oral Janus Kinase Inhibitor, for the Treatment of Rheumatoid Arthritis in Open-label, Longterm Extension Studies by WOLLENHAUPT, Jürgen, SILVERFIELD, Joel, KOMURO, Yoshihiro, ZWILLICH, Samuel H, LISY WANG, RIESE, Richard J, EUN BONG LEE, CURTIS, Jeffrey R, WOOD, Susan P, SOMA, Koshika, NDUAKA, Chudy I, BENDA, Birgitta, GRUBEN, David, NAKAMURA, Hiroyuki

“…To describe the longterm safety and efficacy profile of tofacitinib in patients with moderate to severe active rheumatoid arthritis (RA). Data were pooled from…”
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Tofacitinib or Adalimumab versus Placebo in Rheumatoid Arthritis by van Vollenhoven, Ronald F, Fleischmann, Roy, Cohen, Stanley, Lee, Eun Bong, García Meijide, Juan A, Wagner, Sylke, Forejtova, Sarka, Zwillich, Samuel H, Gruben, David, Koncz, Tamas, Wallenstein, Gene V, Krishnaswami, Sriram, Bradley, John D, Wilkinson, Bethanie

“…In this trial of patients with rheumatoid arthritis who were on stable doses of methotrexate, tofacitinib, a novel oral Janus kinase inhibitor, was more…”
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Identification of Distinct Disease Activity Trajectories in Methotrexate‐Naive Patients With Rheumatoid Arthritis Receiving Tofacitinib Over Twenty‐Four Months by Bykerk, Vivian P., Lee, Eun Bong, Vollenhoven, Ronald, Gruben, David C., Fallon, Lara, Woolcott, John C., Keystone, Edward

“…Objective Tofacitinib is an oral JAK inhibitor for the treatment of rheumatoid arthritis (RA). To better understand tofacitinib treatment responses, we used…”
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The impact of tofacitinib on fatigue, sleep, and health-related quality of life in patients with rheumatoid arthritis: a post hoc analysis of data from Phase 3 trials by Bartlett, Susan J, Bingham, Clifton O, van Vollenhoven, Ronald, Murray, Christopher, Gruben, David, Gold, David A, Cella, David

“…Fatigue, a common symptom of rheumatoid arthritis (RA), is detrimental to health-related quality of life (HRQoL). We evaluated the impact of tofacitinib on…”
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Real-World Comparative Effectiveness of Tofacitinib and Tumor Necrosis Factor Inhibitors as Monotherapy and Combination Therapy for Treatment of Rheumatoid Arthritis by Reed, George W., Gerber, Robert A., Shan, Ying, Takiya, Liza, Dandreo, Kimberly J., Gruben, David, Kremer, Joel, Wallenstein, Gene

“…Introduction No published studies exist comparing the effectiveness of tofacitinib with other advanced therapies for the treatment of rheumatoid arthritis (RA)…”
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Is radiographic progression in modern rheumatoid arthritis trials still a robust outcome? Experience from tofacitinib clinical trials by Landewé, Robert B M, Connell, Carol A, Bradley, John D, Wilkinson, Bethanie, Gruben, David, Strengholt, Sander, van der Heijde, Désirée

“…The detection of statistically significant reductions in radiographic progression during clinical studies in patients with rheumatoid arthritis (RA) has become…”
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Initial Experience With Tofacitinib in Clinical Practice: Treatment Patterns and Costs of Tofacitinib Administered as Monotherapy or in Combination With Conventional Synthetic DMARDs in 2 US Health Care Claims Databases by Harnett, James, PharmD, MS, Curtis, Jeffrey R., MD, Gerber, Robert, PharmD, Gruben, David, PhD, Koenig, Andrew, DO

“…Abstract Purpose Tofacitinib is an oral Janus kinase inhibitor indicated for the treatment of rheumatoid arthritis (RA). Tofacitinib can be administered as a…”
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Sex differences in the efficacy, safety and persistence of patients with psoriatic arthritis treated with tofacitinib: a post-hoc analysis of phase 3 trials and long-term extension by Eder, Lihi, Gladman, Dafna D, Mease, Philip, Pollock, Remy A, Luna, Rayana, Aydin, Sibel Z, Ogdie, Alexis, Polachek, Ari, Gruben, David, Cadatal, Mary Jane, Kinch, Cassandra, Strand, Vibeke

“…BackgroundEvaluate the impact of sex on tofacitinib efficacy, safety and persistence (time to discontinuation) in patients with psoriatic arthritis…”
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Efficacy and Safety of Tofacitinib in Patients with Psoriatic Arthritis or Ankylosing Spondylitis by Cigarette Smoking Status by Ogdie, Alexis, Kristensen, Lars E., Soriano, Enrique R., Akar, Servet, Sun, Yanhui, Gruben, David, Fallon, Lara, Kinch, Cassandra D., Gladman, Dafna D.

“…Introduction Routine care studies of psoriatic arthritis (PsA) and ankylosing spondylitis (AS) demonstrated attenuated responses to tumor necrosis factor…”
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Tofacitinib Safety and Effectiveness in Canadian Patients with Rheumatoid Arthritis by Cardiovascular Risk Enrichment: Subanalysis of the CANTORAL Study by Haraoui, Boulos, Khraishi, Majed, Choquette, Denis, Fortin, Isabelle, Kinch, Cassandra D., Galos, Corina, Roy, Patrice, Gruben, David, Vaillancourt, Julie, Sampalis, John S., Keystone, Edward C.

“…Introduction ORAL Surveillance, a post-authorisation safety study of patients with rheumatoid arthritis (RA) enriched for cardiovascular (CV) risk,…”
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High Usability and Applicability Ratings for the New SmartClic®/ClicWise® Injection Device: Evidence from a Health Care Professional Opinion Study by Alten, Rieke, Moss, Simon, Hahne, Stefanie, Muriset, Angela T., Gruben, David, Latymer, Mark

“…Introduction The SmartClic ® /ClicWise ® autoinjector is a new reusable, multi-use, single-patient device for the administration of subcutaneously administered…”
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Tofacitinib Efficacy in Patients with Rheumatoid Arthritis and Probable Depression/Anxiety: Post Hoc Analysis of Phase 3 and 3b/4 Randomized Controlled Trials by Citera, Gustavo, Jain, Rakesh, Irazoque, Fedra, Madariaga, Hugo, Gruben, David, Wang, Lisy, Stockert, Lori, Santana, Karina, Ebrahim, Abbas, Ponce de Leon, Dario

“…Introduction The aim of our work is to assess the prevalence of probable major depressive disorder and/or probable generalized anxiety disorder (pMDD/pGAD) in…”
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Tofacitinib versus Biologic Treatments in Moderate-to-Severe Rheumatoid Arthritis Patients Who Have Had an Inadequate Response to Nonbiologic DMARDs: Systematic Literature Review and Network Meta-Analysis by Makin, Charles, Lukic, Tatjana, Gruben, David, Gerber, Robert A., Bergrath, Evelien, Wallenstein, Gene

“…Objective. To compare the efficacy and tolerability of tofacitinib, an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA), as…”
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Efficacy of tofacitinib in reducing pain in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis by Ogdie, Alexis, de Vlam, Kurt, McInnes, Iain B, Mease, Philip J, Baer, Philip, Lukic, Tatjana, Gruben, David, Kwok, Kenneth, Wang, Cunshan, Hsu, Ming-Ann, Maniccia, Anna

“…ObjectiveTo describe the efficacy of tofacitinib in reducing pain in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) or ankylosing…”
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Treatment Mode Preferences in Rheumatoid Arthritis: Moving Toward Shared Decision-Making by Taylor, Peter C, Betteridge, Neil, Brown, T Michelle, Woolcott, John, Kivitz, Alan J, Zerbini, Cristiano, Whalley, Diane, Olayinka-Amao, Oyebimpe, Chen, Connie, Dahl, Palle, Ponce de Leon, Dario, Gruben, David, Fallon, Lara

“…Current knowledge of the reasons for patients' preference for rheumatoid arthritis (RA) treatment modes is limited. This study was designed to identify…”
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Tu1823 BAYESIAN NETWORK META-ANALYSIS OF THE EFFICACY OF ADVANCED THERAPIES FOR PATIENTS WITH MODERATELY TO SEVERELY ACTIVE ULCERATIVE COLITIS NAÏVE TO ADVANCED THERAPY by Jairath, Vipul, Leahy, Thomas P., Potluri, Ravi, Wosik, Karolina, Gruben, David, Cappelleri, Joseph C., Bartolome, Lauren

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Tofacitinib in Combination With Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis: A Randomized Trial by KREMER, Joel, LI, Zhan-Guo, ZWILLICH, Samuel H, KONCZ, Tamas, RIESE, Richard, BRADLEY, John, HALL, Stephen, FLEISCHMANN, Roy, GENOVESE, Mark, MARTIN-MOLA, Emilio, ISAACS, John D, GRUBEN, David, WALLENSTEIN, Gene, KRISHNASWAMI, Sriram

“…Many patients with rheumatoid arthritis (RA) do not achieve adequate and safe responses with disease-modifying antirheumatic drugs (DMARDs). Tofacitinib is a…”
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