Search Results - "Grubb, J.H."

The role of glycosylation and phosphorylation in the expression of active human beta-glucuronidase by SHIPLEY, J. M, GRUBB, J. H, SLY, W. S

“…Phosphorylation of mannose residues on N-linked oligosaccharide side chains of lysosomal enzymes targets them to lysosomes. We used site-directed mutagenesis…”
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The insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor mediates IGF-II-induced motility in human rhabdomyosarcoma cells by MINNITI, C. P, KOHN, E. C, GRUBB, J. H, SLY, W. S, OH, Y, MÜLLER, H. L, ROSENFELD, R. G, HELMAN, L. J

“…Insulin-like growth factor-II (IGF-II) is an autocrine growth and motility factor for human rhabdomyosarcoma. It interacts with three different receptors: the…”
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Cloning, sequencing, and functional characterization of the murine 46-kDa mannose 6-phosphate receptor by Ma, Z M, Grubb, J H, Sly, W S

“…We have cloned and sequenced the 2175-nucleotide, full-length cDNA for the mouse 46-kDa Man 6-P receptor (46MPR) and studied its functional properties in…”
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Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium by Karhumaa, P., Parkkila, S., Türeci, Ö., Waheed, A., Grubb, J.H., Shah, G., Parkkila, A.-K., Kaunisto, K., Tapanainen, J., Sly, W.S., Rajaniemi, H.

“…Although previous studies demonstrated carbonic anhydrase (CA) activity in the human endometrium, the CA isozyme(s) responsible for this activity has not been…”
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Mutational analysis of a patient with mucopolysaccharidosis type VII, and identification of pseudogenes by SHIPLEY, J. M, KLINKENBERG, M, WU, B. M, BACHINSKY, D. R, GRUBB, J. H, SLY, W. S

“…PCR of cDNA produced from patient fibroblasts allowed us to determine the paternal mutation in the first patient reported with beta-glucuronidase-deficiency…”
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C-terminal processing of human beta-glucuronidase. The propeptide is required for full expression of catalytic activity, intracellular retention, and proper phosphorylation by Islam, M.R., Grubb, J.H., Sly, W.S.

“…beta-Glucuronidase undergoes proteolytic C-terminal processing during or after its transport to lysosomes or endosomes. We determined the C-terminal processing…”
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The Overexpressed Human 46-kDa Mannose 6-Phosphate Receptor Mediates Endocytosis and Sorting of β-Glucuronidase by Watanabe, Hiroshi, Grubb, Jeffrey H., Sly, William S.

“…We studied the function of the human small (46-kDa) mannose 6-phosphate receptor (SMPR) in transfected mouse L cells that do not express the larger…”
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Cloning, Sequencing, and Expression of cDNA for Human β -glucuronidase by Oshima, Akihiro, Kyle, John W., Miller, Raymond D., Hoffmann, Joseph W., Powell, Penelope P., Grubb, Jeffrey H., Sly, William S., Tropak, Michael, Guise, Kevin S., Gravel, Roy A.

“…We report here the cDNA sequence for human placental β -glucuronidase (β -D-glucuronoside glucuronosohydrolase, EC 3.2.1.31) and demonstrate expression of the…”
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Divalent cation-dependent stimulation of ligand binding to the 46-kDa mannose 6-phosphate receptor correlates with divalent cation-dependent tetramerization by MA, Z, GRUBB, J. H, SLY, W. S

“…The quaternary structure and binding activity of the murine 46-kDa mannose 6-phosphate receptor (46MPR) were studied in semi-intact murine cells that…”
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