Search Results - "Groves, R"

Theory and applications of differential scanning fluorimetry in early-stage drug discovery by Gao, Kai, Oerlemans, Rick, Groves, Matthew R.

“…Differential scanning fluorimetry (DSF) is an accessible, rapid, and economical biophysical technique that has seen many applications over the years, ranging…”
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Repurposing the HCV NS3-4A protease drug boceprevir as COVID-19 therapeutics by Oerlemans, Rick, Ruiz-Moreno, Angel Jonathan, Cong, Yingying, Dinesh Kumar, Nilima, Velasco-Velazquez, Marco A, Neochoritis, Constantinos G, Smith, Jolanda, Reggiori, Fulvio, Groves, Matthew R, Dömling, Alexander

“…The rapid growth of COVID-19 cases is causing an increasing death toll and also paralyzing the world economy. De novo drug discovery takes years to move from…”
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common brain network links development, aging, and vulnerability to disease by Douaud, Gwenaëlle, Groves, Adrian R., Tamnes, Christian K., Westlye, Lars Tjelta, Duff, Eugene P., Engvig, Andreas, Walhovd, Kristine B., James, Anthony, Gass, Achim, Monsch, Andreas U., Matthews, Paul M., Fjell, Anders M., Smith, Stephen M., Johansen-Berg, Heidi

“…Significance Many evolutionary–developmental models have attempted to relate development and aging, with one popular hypothesis proposing that healthy…”
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Stapled Peptides Inhibitors: A New Window for Target Drug Discovery by Ali, Ameena M., Atmaj, Jack, Van Oosterwijk, Niels, Groves, Matthew R., Dömling, Alexander

“…Protein-protein interaction (PPI) is a hot topic in clinical research as protein networking has a major impact in human disease. Such PPIs are potential drugs…”
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British Association of Dermatologists’ guidelines for the management of pemphigus vulgaris 2017 by Harman, K.E., Brown, D., Exton, L.S., Groves, R.W., Hampton, P.J., Mohd Mustapa, M.F., Setterfield, J.F., Yesudian, P.D.

“…Plain language summary available online…”
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Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain by Gawriljuk, Victor O., Godoy, Andre S., Oerlemans, Rick, Welker, Luise A. T., Hirsch, Anna K. H., Groves, Matthew R.

“…Plasmodium falciparum is the main causative agent of malaria, a deadly disease that mainly affects children under five years old. Artemisinin-based combination…”
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Integrating Spectroscopy with Potato Disease Management by Couture, J J, Singh, A, Charkowski, A O, Groves, R L, Gray, S M, Bethke, P C, Townsend, P A

“…Spectral phenotyping is an efficient method for the nondestructive characterization of plant biochemical and physiological status. We examined the ability of a…”
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A Cyclic Nucleotide-Gated Channel (CNGC16) in Pollen Is Critical for Stress Tolerance in Pollen Reproductive Development by Tunc-Ozdemir, Meral, Tang, Chong, Ishka, Maryam Rahmati, Brown, Elizabeth, Groves, Norman R., Myers, Candace T., Rato, Claudia, Poulsen, Lisbeth R., McDowell, Stephen, Miller, Gad, Mittler, Ron, Harper, Jeffrey F.

“…Cyclic nucleotide-gated channels (CNGCs) have been implicated in diverse aspects of plant growth and development, including responses to biotic and abiotic…”
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Correction: Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment by Rashidi, Fatma B, Al-Qahtani, Alanod D, Bashraheel, Sara S, Shaabani, Shabnam, Groves, Matthew R, Dömling, Alexander, Goda, Sayed K

“…[This corrects the article DOI: 10.1371/journal.pone.0196254.]…”
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The aroma of TEMED as an activation and stabilizing signal for the antibacterial enzyme HEWL by Seraj, Zahra, Ahmadian, Shahin, Groves, Matthew R, Seyedarabi, Arefeh

“…The unpleasant smell released from dead bodies, may serve as an alarm for avoiding certain behaviour or as feeding or oviposition attractants for animals…”
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Dynamic Changes in Plant Nuclear Organization in Response to Environmental and Developmental Signals by Groves, Norman R., Biel, Alecia M., Newman-Griffis, Anna H., Meier, Iris

“…The functional organization of the plant nuclear pore, nuclear envelope, and nucleoplasm marks dynamically changing environmental cues and developmental…”
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Nanoscale, automated, high throughput synthesis and screening for the accelerated discovery of protein modifiers by Gao, Kai, Shaabani, Shabnam, Xu, Ruixue, Zarganes-Tzitzikas, Tryfon, Gao, Li, Ahmadianmoghaddam, Maryam, Groves, Matthew R, Dömling, Alexander

“…Hit finding in early drug discovery is often based on high throughput screening (HTS) of existing and historical compound libraries, which can limit chemical…”
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Fragment Screening in the Development of a Novel Anti-Malarial by Du, Xiaochen, Zhang, Ran, Groves, Matthew R

“…Fragment-based approaches offer rapid screening of chemical space and have become a mainstay in drug discovery. This manuscript provides a recent example that…”
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Distinct Roles for KASH Proteins SINE1 and SINE2 in Guard Cell Actin Reorganization, Calcium Oscillations, and Vacuolar Remodeling by Biel, Alecia, Moser, Morgan, Groves, Norman R, Meier, Iris

“…The linker of nucleoskeleton and cytoskeleton (LINC) complex is a protein complex spanning the inner and outer membranes of the nuclear envelope. Outer nuclear…”
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High Throughput Synthesis and Screening of Oxygen Reduction Catalysts in the MTiO3 (M = Ca, Sr, Ba) Perovskite Phase Diagram by Groves, Alexandra R, Ashton, Thomas E, Darr, Jawwad A

“…A library of 66 perovskite Ba x Sr y Ca z TiO3 (x + y + z = 1) samples (ca. three grams per sample) was made in ca. 14 h using a high-throughput continuous…”
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Dr Balbir Singh Bhogal: 1950-2016 by Groves, R., Black, M.

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Load monitoring of a cantilever plate by a novel multimodal fibre optic sensing configuration by Nazeer, N., Groves, R. M.

“…Optical fibre sensors and in particular fibre Bragg gratings (FBG) have received a lot of interest for Structural Health Monitoring in different application…”
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Variational Bayesian Inference for a Nonlinear Forward Model by Chappell, M.A., Groves, A.R., Whitcher, B., Woolrich, M.W.

“…Variational Bayes (VB) has been proposed as a method to facilitate calculations of the posterior distributions for linear models, by providing a fast method…”
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The risk of tuberculosis related to tumour necrosis factor antagonist therapies: a TBNET consensus statement by SOLOVIC, I, SESTER, M, WALLIS, R. S, SOTGIU, G, SCHÖLVINCK, E. H, GOLETTI, D, ZELLWEGER, J. P, DIEL, R, CARMONA, L, BARTALESI, F, RAVN, P, BOSSINK, A, GOMEZ-REINO, J. J, DUARTE, R, ERKENS, C, CLARK, J, MIGLIORI, G. B, LANGE, C, RIEDER, H. L, EHLERS, S, MILBURN, H. J, KAMPMANN, B, HELLMICH, B, GROVES, R, SCHREIBER, S

“…Anti-tumour necrosis factor (TNF) monoclonal antibodies or soluble TNF receptors have become an invaluable treatment against chronic inflammatory diseases,…”
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A nuclear localization signal targets tail-anchored membrane proteins to the inner nuclear envelope in plants by Groves, Norman R, McKenna, Joseph F, Evans, David E, Graumann, Katja, Meier, Iris

“…Protein targeting to the inner nuclear membrane (INM) is one of the least understood protein targeting pathways. INM proteins are important for chromatin…”
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