Search Results - "Groves, Maria A T"

Extensive sequence and structural evolution of Arginase 2 inhibitory antibodies enabled by an unbiased approach to affinity maturation by Chan, Denice T. Y., Jenkinson, Lesley, Haynes, Stuart W., Austin, Mark, Diamandakis, Agata, Burschowsky, Daniel, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H., Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Wilkinson, Robert W., Vaughan, Tristan J., Holt, Sarah V., Cerundolo, Vincenzo, Carr, Mark D., Groves, Maria A. T.

“…Affinity maturation is a powerful technique in antibody engineering for the in vitro evolution of antigen binding interactions. Key to the success of this…”
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Antibody VH and VL recombination using phage and ribosome display technologies reveals distinct structural routes to affinity improvements with VH-VL interface residues providing important structural diversity by Groves, Maria AT, Amanuel, Lily, Campbell, Jamie I, Rees, D Gareth, Sridharan, Sudharsan, Finch, Donna K, Lowe, David C, Vaughan, Tristan J

“…In vitro selection technologies are an important means of affinity maturing antibodies to generate the optimal therapeutic profile for a particular disease…”
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Generation of potent mouse monoclonal antibodies to self-proteins using T-cell epitope "tags" by Percival-Alwyn, Jennifer L, England, Elizabeth, Kemp, Benjamin, Rapley, Laura, Davis, Nicola H E, McCarthy, Grant R, Majithiya, Jayesh B, Corkill, Dominic J, Welsted, Sarah, Minton, Kevin, Cohen, E Suzanne, Robinson, Matthew J, Dobson, Claire, Wilkinson, Trevor C I, Vaughan, Tristan J, Groves, Maria A T, Tigue, Natalie J

“…Immunization of mice or rats with a "non-self" protein is a commonly used method to obtain monoclonal antibodies, and relies on the immune system's ability to…”
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Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action by Austin, Mark, Burschowsky, Daniel, Chan, Denice T Y, Jenkinson, Lesley, Haynes, Stuart, Diamandakis, Agata, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H, Hadjinicolaou, Andreas V, Gileadi, Uzi, Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Kaserer, Teresa, Sharma, Pooja, Luheshi, Nadia M, Wilkinson, Robert W, Vaughan, Tristan J, Holt, Sarah V, Cerundolo, Vincenzo, Carr, Mark D, Groves, Maria A T

“…Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 within specific tumor…”
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Applications of ribosome display to antibody drug discovery by Groves, Maria A T, Osbourn, Jane K

“…Ribosome display is a polymerase chain reaction-based in vitro display technology that is well suited to the selection and evolution of high affinity…”
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Selection of hapten-specific single-domain antibodies from a non-immunized llama ribosome display library by Yau, Kerrm Y.F, Groves, Maria A.T, Li, Shenghua, Sheedy, Claudia, Lee, Hung, Tanha, Jamshid, MacKenzie, C.Roger, Jermutus, Lutz, Hall, J.Christopher

“…Picloram-specific variable fragments (V HHs) of heavy chain antibodies (HCAbs) were selected from a naı̈ve-llama library using ribosome display technology. A…”
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Affinity maturation: highlights in the application of in vitro strategies for the directed evolution of antibodies by Chan, Denice T Y, Groves, Maria A T

“…Affinity maturation is a key technique in protein engineering which is used to improve affinity and binding interactions in vitro, a process often required to…”
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Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action by Austin, Mark, Burschowsky, Daniel, Chan, Denice T.Y., Jenkinson, Lesley, Haynes, Stuart, Diamandakis, Agata, Seewooruthun, Chitra, Addyman, Alexandra, Fiedler, Sebastian, Ryman, Stephanie, Whitehouse, Jessica, Slater, Louise H., Hadjinicolaou, Andreas V., Gileadi, Uzi, Gowans, Ellen, Shibata, Yoko, Barnard, Michelle, Kaserer, Teresa, Sharma, Pooja, Luheshi, Nadia M., Wilkinson, Robert W., Vaughan, Tristan J., Holt, Sarah V., Cerundolo, Vincenzo, Carr, Mark D., Groves, Maria A. T.

“…Arginase 2 (ARG2) is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of L-arginine. The dysregulated expression of ARG2 within specific tumor…”
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Generation of potent mouse monoclonal antibodies to self-proteins using T-cell epitope "tags" by Percival-Alwyn, Jennifer L, England, Elizabeth, Kemp, Benjamin, Rapley, Laura, Davis, Nicola HE, McCarthy, Grant R, Majithiya, Jayesh B, Corkill, Dominic J, Welsted, Sarah, Minton, Kevin, Cohen, E Suzanne, Robinson, Matthew J, Dobson, Claire, Wilkinson, Trevor CI, Vaughan, Tristan J, Groves, Maria AT, Tigue, Natalie J

“…Immunization of mice or rats with a "non-self" protein is a commonly used method to obtain monoclonal antibodies, and relies on the immune system's ability to…”
Get full text