Search Results - "Groves, C J"

Duodenal cancer in patients with familial adenomatous polyposis (FAP): results of a 10 year prospective study by Groves, C J, Saunders, B P, Spigelman, A D, Phillips, R K S

“…Background: Duodenal cancer is one of the leading causes of death in familial adenomatous polyposis (FAP) patients. An endoscopic surveillance programme was…”
Get full text

Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome by Barber, T. M, Bennett, A. J, Groves, C. J, Sovio, U, Ruokonen, A, Martikainen, H, Pouta, A, Hartikainen, A.-L, Elliott, P, Lindgren, C. M, Freathy, R. M, Koch, K, Ouwehand, W. H, Karpe, F, Conway, G. S, Wass, J. A. H, Järvelin, M.-R, Franks, S, McCarthy, M. I

“…Aims/hypothesis Variants in the fat-mass and obesity-associated gene (FTO) influence susceptibility to type 2 diabetes via an effect on adiposity/obesity…”
Get full text

Lorenz Curve and Gini Coefficient: Novel tools for analysing seasonal variation of environmental radon gas by Groves-Kirkby, C.J., Denman, A.R., Phillips, P.S.

“…Using a methodology derived from Economics, the Lorenz Curve and Gini Coefficient are introduced as tools for investigating and quantifying seasonal…”
Get full text

Pylorus-preserving pancreaticoduodenectomy for advanced duodenal disease in familial adenomatous polyposis by Gallagher, M. C., Shankar, A., Groves, C. J., Russell, R. C. G., Phillips, R. K. S.

“…Background: Although only 5 per cent of patients with familial adenomatous polyposis (FAP) die from duodenal cancer, a recent study indicated that the…”
Get full text

Tidal synchronicity of built-environment radon levels in the UK by Crockett, R. G. M., Gillmore, G. K., Phillips, P. S., Denman, A. R., Groves-Kirkby, C. J.

“…In our recent work on radon in UK homes the authors have observed tidal‐periodic variations in built‐environment radon levels and here report results from our…”
Get full text

Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes by ZEGGINI, E, GROVES, C. J, HATTERSLEY, A. T, MCCARTHY, M. I, PARKINSON, J. R. C, HALFORD, S, OWEN, K. R, FRAYLING, T. M, WALKER, M, HITMAN, G. A, LEVY, J. C, O'RAHILLY, S

“…The proinflammatory cytokine TNF-alpha has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, and variation in the gene encoding…”
Get full text

role for coding functional variants in HNF4A in type 2 diabetes susceptibility by Jafar-Mohammadi, B, Groves, C. J, Gjesing, A. P, Herrera, B. M, Winckler, W, Stringham, H. M, Morris, A. P, Lauritzen, T, Doney, A. S. F, Morris, A. D, Weedon, M. N, Swift, A. J, Kuusisto, J, Laakso, M, Altshuler, D, Hattersley, A. T, Collins, F. S, Boehnke, M, Hansen, T, Pedersen, O, Palmer, C. N. A, Frayling, T. M, Gloyn, A. L, McCarthy, M. I

“…Aims/hypothesis Rare mutations in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4α (HNF-4A), account for ~5% of cases of MODY and…”
Get full text

Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS by Barber, T. M, Bennett, A. J, Groves, C. J, Sovio, U, Ruokonen, A, Martikainen, H, Pouta, A, Hartikainen, A.-L, Elliott, P, Wass, J. A. H, Järvelin, M.-R, Zeggini, E, Franks, S, McCarthy, M. I

“…Aims/hypothesis Common variants of the gene encoding transcription factor 7-like 2 (TCF7L2) have a powerful effect on individual risk of type 2 diabetes (per…”
Get full text

Radon anomalies preceding earthquakes which occurred in the UK, in summer and autumn 2002 by Crockett, R.G.M., Gillmore, G.K., Phillips, P.S., Denman, A.R., Groves-Kirkby, C.J.

“…During the course of an investigation into domestic radon levels in Northamptonshire, two hourly sampling real-time radon detectors were operated…”
Get full text

Prevalence and clinical characteristics of maternally inherited diabetes and deafness caused by the mt3243A > G mutation in young adult diabetic subjects in Sri Lanka by Katulanda, P., Groves, C. J., Barrett, A., Sheriff, R., Matthews, D. R., McCarthy, M. I., Gloyn, A. L.

“…Aims  The maternally inherited mt3243A > G mutation is associated with a variable clinical phenotype including diabetes and deafness (MIDD). We aimed to…”
Get full text

Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism by LIEW, C. F, GROVES, C. J, HATTERSLEY, A. T, JOHNSTON, D. G, MCCARTHY, M. I, WILTSHIRE, S, ZEGGINI, E, FRAYLING, T. M, OWEN, K. R, WALKER, M, HITMAN, G. A, LEVY, J. C, O'RAHILLY, S

“…Stearoyl-CoA desaturase (SCD) is emerging as a key regulator of lipid and carbohydrate metabolism. Scd-null mice display a beneficial metabolic phenotype…”
Get full text

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes by Albrechtsen, A., Grarup, N., Li, Y., Sparsø, T., Cao, H., Jiang, T., Kim, S. Y., Korneliussen, T., Li, Q., Nie, C., Wu, R., Morris, A. P., Ladenvall, C., Cauchi, S., Stančáková, A., Andersen, G., Astrup, A., Banasik, K., Bennett, A. J., Bolund, L., Charpentier, G., Chen, Y., Dekker, J. M., Doney, A. S. F., Dorkhan, M., Forsen, T., Frayling, T. M., Gui, Y., Hallmans, G., Hattersley, A. T., He, K., Hitman, G. A., Holmkvist, J., Huang, S., Jiang, H., Jin, X., Justesen, J. M., Kristiansen, K., Kuusisto, J., Lajer, M., Lantieri, O., Li, W., Liao, Q., Liu, X., Ma, T., Ma, X., Marre, M., Mokrosiński, J., Morris, A. D., Mu, B., Nielsen, A. A., Nijpels, G., Nilsson, P., Palmer, C. N. A., Rayner, N. W., Renström, F., Ribel-Madsen, R., Robertson, N., Rolandsson, O., Rossing, P., Schwartz, T. W., Slagboom, P. E., Sterner, M., Tang, M., Tarnow, L., Tuomi, T., van’t Riet, E., van Leeuwen, N., Varga, T. V., Vestmar, M. A., Walker, M., Wang, B., Wang, Y., Wu, H., Xi, F., Yengo, L., Yu, C., Zhang, J., Zhang, Q., Zhang, W., Zheng, H., Zhou, Y., Altshuler, D., ‘t Hart, L. M., Franks, P. W., Balkau, B., Froguel, P., McCarthy, M. I., Laakso, M., Groop, L., Christensen, C., Brandslund, I., Lauritzen, T., Witte, D. R., Linneberg, A., Jørgensen, T., Hansen, T., Wang, J., Nielsen, R., Pedersen, O.

“…Aims/hypothesis Human complex metabolic traits are in part regulated by genetic determinants. Here we applied exome sequencing to identify novel associations…”
Get full text

Radon mitigation in domestic properties and its health implications—a comparison between during-construction and post-construction radon reduction by Groves-Kirkby, C.J., Denman, A.R., Phillips, P.S., Crockett, R.G.M., Woolridge, A.C., Tornberg, R.

“…Although United Kingdom (UK) Building Regulations applicable to houses constructed since 1992 in Radon Affected Areas address the health issues arising from…”
Get full text

The cost effectiveness of radon reduction programmes in domestic housing in England and Wales: The impact of improved radon mapping and housing trends by Denman, A.R., Sinclair, J., Phillips, P.S., Crockett, R.G.M., Groves-Kirkby, C.J.

“…In the UK, excessive levels of radon gas have been detected in domestic housing. Areas where 1% of existing homes were found to be over the Action Level of…”
Get full text

Time-integrating radon gas measurements in domestic premises: comparison of short-, medium- and long-term exposures by Groves-Kirkby, C.J., Denman, A.R., Crockett, R.G.M., Phillips, P.S., Woolridge, A.C., Gillmore, G.K.

“…To identify the most applicable technology for the short-term assessment of domestic radon levels, comparative assessments of a number of integrating detector…”
Get full text

Comparison of seasonal variability in European domestic radon measurements by Groves-Kirkby, C. J., Denman, A. R., Phillips, P. S., Crockett, R. G. M., Sinclair, J. M.

“…Analysis of published data characterising seasonal variability of domestic radon concentrations in Europe and elsewhere shows significant variability between…”
Get full text

CD19-positive antibody-secreting cells provide immune memory by Groves, C.J., Carrell, J., Grady, R., Rajan, B., Morehouse, C.A., Halpin, R., Wang, J., Wu, J., Shrestha, Y., Rayanki, R., Kolbeck, R., Wang, Y., Herbst, R.

“…Long-lived antibody-secreting cells (ASCs) are critical for the maintenance of humoral immunity through the continued production of antibodies specific for…”
Get full text

The value of Seasonal Correction Factors in assessing the health risk from domestic radon—A case study in Northamptonshire, UK by Denman, A.R., Crockett, R.G.M., Groves-Kirkby, C.J., Phillips, P.S., Gillmore, G.K., Woolridge, A.C.

“…Following an intensive survey of domestic radon levels in the United Kingdom (UK), the former National Radiological Protection Board (NRPB), now the Radiation…”
Get full text

Identification of tidal and climatic influences within domestic radon time-series from Northamptonshire, UK by Groves-Kirkby, C.J., Denman, A.R., Crockett, R.G.M., Phillips, P.S., Gillmore, G.K.

“…Analysis of data from extended radon concentration time-series obtained from domestic and public-sector premises in the vicinity of Northampton, UK, and…”
Get full text

Lung-cancer reduction from smoking cessation and radon remediation: A preliminary cost-analysis in Northamptonshire, UK by Groves-Kirkby, C.J., Timson, K., Shield, G., Denman, A.R., Rogers, S., Phillips, P.S.

“…Domestic radon levels in parts of the United Kingdom are sufficiently high as to increase the risk of lung-cancer among residents. Public health campaigns in…”
Get full text