Search Results - "Grove, Joe"

The cell biology of receptor-mediated virus entry by Grove, Joe, Marsh, Mark

“…The cell imposes multiple barriers to virus entry. However, viruses exploit fundamental cellular processes to gain entry to cells and deliver their genetic…”
Get full text

Super-resolution microscopy: a virus' eye view of the cell by Grove, Joe

“…It is difficult to observe the molecular choreography between viruses and host cell components, as they exist on a spatial scale beyond the reach of…”
Get full text

Structures of the Hepaci-, Pegi-, and Pestiviruses envelope proteins suggest a novel membrane fusion mechanism by Oliver, Michael R, Toon, Kamilla, Lewis, Charlotte B, Devlin, Stephen, Gifford, Robert J, Grove, Joe

“…Enveloped viruses encode specialised glycoproteins that mediate fusion of viral and host membranes. Discovery and understanding of the molecular mechanisms of…”
Get full text

Short-Sighted Virus Evolution and a Germline Hypothesis for Chronic Viral Infections by Lythgoe, Katrina A, Gardner, Andy, Pybus, Oliver G, Grove, Joe

“…With extremely short generation times and high mutability, many viruses can rapidly evolve and adapt to changing environments. This ability is generally…”
Get full text

Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint by Schmidt, Nathalie M., Wing, Peter A. C., Diniz, Mariana O., Pallett, Laura J., Swadling, Leo, Harris, James M., Burton, Alice R., Jeffery-Smith, Anna, Zakeri, Nekisa, Amin, Oliver E., Kucykowicz, Stephanie, Heemskerk, Mirjam H., Davidson, Brian, Meyer, Tim, Grove, Joe, Stauss, Hans J., Pineda-Torra, Ines, Jolly, Clare, Jury, Elizabeth C., McKeating, Jane A., Maini, Mala K.

“…Determining divergent metabolic requirements of T cells, and the viruses and tumours they fail to combat, could provide new therapeutic checkpoints. Inhibition…”
Get full text

Flat clathrin lattices: stable features of the plasma membrane by Grove, Joe, Metcalf, Daniel J, Knight, Alex E, Wavre-Shapton, Silène T, Sun, Tony, Protonotarios, Emmanouil D, Griffin, Lewis D, Lippincott-Schwartz, Jennifer, Marsh, Mark

“…Clathrin-mediated endocytosis (CME) is a fundamental property of eukaryotic cells. Classical CME proceeds via the formation of clathrin-coated pits (CCPs) at…”
Get full text

Flexibility and intrinsic disorder are conserved features of hepatitis C virus E2 glycoprotein by Stejskal, Lenka, Lees, William D, Moss, David S, Palor, Machaela, Bingham, Richard J, Shepherd, Adrian J, Grove, Joe

“…The glycoproteins of hepatitis C virus, E1E2, are unlike any other viral fusion machinery yet described, and are the current focus of immunogen design in HCV…”
Get full text

Building a mechanistic mathematical model of hepatitis C virus entry by Kalemera, Mphatso, Mincheva, Dilyana, Grove, Joe, Illingworth, Christopher J R

“…The mechanism by which hepatitis C virus (HCV) gains entry into cells is a complex one, involving a broad range of host proteins. Entry is a critical phase of…”
Get full text

Multiple effects of silymarin on the hepatitis C virus lifecycle by Wagoner, Jessica, Negash, Amina, Kane, Olivia J., Martinez, Laura E., Nahmias, Yaakov, Bourne, Nigel, Owen, David M., Grove, Joe, Brimacombe, Claire, McKeating, Jane A., Pécheur, Eve‐Isabelle, Graf, Tyler N., Oberlies, Nicholas H., Lohmann, Volker, Cao, Feng, Tavis, John E., Polyak, Stephen J.

“…Silymarin, an extract from milk thistle (Silybum marianum), and its purified flavonolignans have been recently shown to inhibit hepatitis C virus (HCV)…”
Get full text

Neutralizing Antibody-Resistant Hepatitis C Virus Cell-to-Cell Transmission by BRIMACOMBE, Claire L, GROVE, Joe, WONG-STAAL, Flossie, BALFE, Peter, MCKEATING, Jane A, MEREDITH, Luke W, KE HU, SYDER, Andrew J, FLORES, Maria Victoria, TIMPE, Jennifer M, KRIEGER, Sophie E, BAUMERT, Thomas F, TELLINGHUISEN, Timothy L

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
Get full text

Regulation of Endocytic Clathrin Dynamics by Cargo Ubiquitination by Henry, Anastasia G., Hislop, James N., Grove, Joe, Thorn, Kurt, Marsh, Mark, von Zastrow, Mark

“…Some endocytic cargoes control clathrin-coated pit (CCP) maturation, but it is not known how such regulation is communicated. We found that μ-opioid…”
Get full text

Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process by Davies, Scott P., Reynolds, Gary M., Wilkinson, Alex L., Li, Xiaoyan, Rose, Rebecca, Leekha, Maanav, Liu, Yuxin S., Gandhi, Ratnam, Buckroyd, Emma, Grove, Joe, Barnes, Nicholas M., May, Robin C., Hubscher, Stefan G., Adams, David H., Huang, Yuehua, Qureshi, Omar, Stamataki, Zania

“…CD4+ T cells play critical roles in directing immunity, both as T helper and as regulatory T (Treg) cells. Here, we demonstrate that hepatocytes can modulate…”
Get full text

A novel and robust method for counting components within bio-molecular complexes using fluorescence microscopy and statistical modelling by Mersmann, Sophia F., Johns, Emma, Yong, Tracer, McEwan, Will A., James, Leo C., Cohen, Edward A. K., Grove, Joe

“…Cellular biology occurs through myriad interactions between diverse molecular components, many of which assemble in to specific complexes. Various techniques…”
Get full text

Author Correction: Propylene glycol inactivates respiratory viruses and prevents airborne transmission by Styles, Christine T, Zhou, Jie, Flight, Katie E, Brown, Jonathan C, Lewis, Charlotte, Wang, Xinyu, Oever, Michael Vanden, Peacock, Thomas P, Wang, Ziyin, Millns, Rosie, O’Neill, John S, Borodavka, Alexander, Grove, Joe, Barclay, Wendy S, Tregoning, John S, Edgar, Rachel S

Get full text

Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies by GROVE, Joe, NIELSEN, Søren, JIN ZHONG, BASSENDINE, Margaret F, DRUMMER, Heidi E, BALFE, Peter, MCKEATING, Jane A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Propylene glycol inactivates respiratory viruses and prevents airborne transmission by Styles, Christine T, Zhou, Jie, Flight, Katie E, Brown, Jonathan C, Lewis, Charlotte, Wang, Xinyu, Vanden Oever, Michael, Peacock, Thomas P, Wang, Ziyin, Millns, Rosie, O'Neill, John S, Borodavka, Alexander, Grove, Joe, Barclay, Wendy S, Tregoning, John S, Edgar, Rachel S

“…Viruses are vulnerable as they transmit between hosts, and we aimed to exploit this critical window. We found that the ubiquitous, safe, inexpensive and…”
Get full text

Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry by Mazzon, Michela, Ortega-Prieto, Ana Maria, Imrie, Douglas, Luft, Christin, Hess, Lena, Czieso, Stephanie, Grove, Joe, Skelton, Jessica Katy, Farleigh, Laura, Bugert, Joachim J, Wright, Edward, Temperton, Nigel, Angell, Richard, Oxenford, Sally, Jacobs, Michael, Ketteler, Robin, Dorner, Marcus, Marsh, Mark

“…Viruses are a major threat to human health and economic well-being. In recent years Ebola, Zika, influenza, and chikungunya virus epidemics have raised…”
Get full text

Effect of Cell Polarization on Hepatitis C Virus Entry by MEE, Christopher J, GROVE, Joe, HARRIS, Helen J, KE HU, BALFE, Peter, MCKEATING, Jane A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

An entropic safety catch controls hepatitis C virus entry and antibody resistance by Stejskal, Lenka, Kalemera, Mphatso D, Lewis, Charlotte B, Palor, Machaela, Walker, Lucas, Daviter, Tina, Lees, William D, Moss, David S, Kremyda-Vlachou, Myrto, Kozlakidis, Zisis, Gallo, Giulia, Bailey, Dalan, Rosenberg, William, Illingworth, Christopher J R, Shepherd, Adrian J, Grove, Joe

“…E1 and E2 (E1E2), the fusion proteins of Hepatitis C Virus (HCV), are unlike that of any other virus yet described, and the detailed molecular mechanisms of…”
Get full text

Scavenger Receptor BI and BII Expression Levels Modulate Hepatitis C Virus Infectivity by GROVE, Joe, HUBY, Thierry, BAIFE, Peter, MCKEATING, Jane A, STAMATAKI, Zania, VANWOLLEGHEM, Thomas, MEULEMAN, Philip, FARQUHAR, Michelle, SCHWARZ, Anne, MOREAU, Martine, OWEN, James S, LEROUX-ROELS, Geert

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text