Search Results - "Groundwater, Paul W"

Methods for the detection and identification of pathogenic bacteria: past, present, and future by Váradi, Linda, Luo, Jia Lin, Hibbs, David E, Perry, John D, Anderson, Rosaleen J, Orenga, Sylvain, Groundwater, Paul W

“…In order to retard the rate of development of antibacterial resistance, the causative agent must be identified as rapidly as possible, so that directed patient…”
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A Guide to In Silico Drug Design by Chang, Yiqun, Hawkins, Bryson A, Du, Jonathan J, Groundwater, Paul W, Hibbs, David E, Lai, Felcia

“…The drug discovery process is a rocky path that is full of challenges, with the result that very few candidates progress from hit compound to a commercially…”
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3,5-bis(styryl)pyrazole inhibits mitosis and induces cell death independent of BubR1 and p53 levels by depolymerizing microtubules by Batra, Pooja J, Kumari, Anuradha, Liao, Vivian W Y, Hibbs, David E, Groundwater, Paul W, Panda, Dulal

“…Abstract Here, we show that 3,5-bis[(1E)-2-(2,6-dichlorophenyl)ethenyl]-1H-pyrazole 2l depolymerizes microtubules and reduces the number of growing tips of…”
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Discovery of 2′,6-Bis(4-hydroxybenzyl)-2-acetylcyclohexanone, a Novel FtsZ Inhibitor by Lin, Hsuan-Yu J, Battaje, Rachana Rao, Tan, Jinlong, Doddareddy, Munikumar, Dhaked, Hemendra Pal Singh, Srivastava, Shalini, Hawkins, Bryson A, Al-Shdifat, Laith Mohammad Hilal, Hibbs, David E, Panda, Dulal, Groundwater, Paul W

“…Multi-drug resistance is increasing in the pathogenic bacterium S. pneumoniae, which is mainly responsible for meningitis and community-acquired pneumonia…”
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A Selective, Dual Emission β-Alanine Aminopeptidase Activated Fluorescent Probe for the Detection of Pseudomonas aeruginosa , Burkholderia cepacia , and Serratia marcescens by Váradi, Linda, Najib, Elias Y, Hibbs, David E, Perry, John D, Groundwater, Paul W

“…Selective detection of β-alanyl aminopeptidase (BAP)-producing , , and was achieved by employing the blue-to-yellow fluorescent transition of a BAP-specific…”
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Tetracyclic triterpenoids in herbal medicines and their activities in diabetes and its complications by Hamid, Kaiser, Alqahtani, Ali, Kim, Moon-Sun, Cho, Jun-Lae, Cui, Pei H, Li, Chun Guang, Groundwater, Paul W, Li, George Q

“…Tetracyclic triterpenoids, including the dammarane, cucurbitane, cycloartane, lanostane and protostane groups, is a class of triterpenoids widely distributed…”
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Evaluation of fluorogenic aminonaphthalenesulfonamides and 6-hydrazinobenz[de]isoquinoline-1,3-diones for the detection of bacteria by Luo, Jia Lin, Jin, Terry, Váradi, Linda, Perry, John D., Hibbs, David E., Groundwater, Paul W.

“…New fluorogenic enzyme substrates were synthesized by the coupling of aminonaphthalenesulfonamides or 6-hydrazinobenz[de]isoquinoline-1,3-diones with…”
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The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists by Matin, Azadeh, Doddareddy, Munikumar Reddy, Gavande, Navnath, Nammi, Srinivas, Groundwater, Paul W., Roubin, Rebecca H., Hibbs, David E.

“…Twenty three dual PPARα and γ molecules of natural product origin, previously reported by our group, were further investigated for pan PPAR transactivation…”
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Monoclinic Paracetamol vs. Paracetamol-4,4′-Bipyridine Co-Crystal; What Is the Difference? A Charge Density Study by Du, Jonathan, Lai, Felcia, Váradi, Linda, Williams, Peter, Groundwater, Paul, Platts, James, Hibbs, David, Overgaard, Jacob

“…Paracetamol (PCM) has two well-documented polymorphic forms at room temperature; monoclinic Form I is more stable than the other orthorhombic Form II. Form II…”
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Can we Predict Drug Excretion into Saliva? A Systematic Review and Analysis of Physicochemical Properties by Nguyen, Thi A., Chen, Ricky H., Hawkins, Bryson A., Hibbs, David E., Kim, Hannah Y., Wheate, Nial J., Groundwater, Paul W., Stocker, Sophie L., Alffenaar, Jan-Willem C.

“…Background and Objectives Saliva is a patient-friendly matrix for therapeutic drug monitoring (TDM) but is infrequently used in routine care. This is due to…”
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Novel diagnostics for point-of-care bacterial detection and identification by Reali, Savannah, Najib, Elias Y, Treuerné Balázs, Krisztina E, Chern Hui Tan, Adeline, Váradi, Linda, Hibbs, David E, Groundwater, Paul W

“…In addition to limiting the effectiveness of antimicrobial agents, antimicrobial resistance (AMR) is a significant global health concern as it is responsible…”
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cyp51A Mutations, Extrolite Profiles, and Antifungal Susceptibility in Clinical and Environmental Isolates of the Aspergillus viridinutans Species Complex by Talbot, Jessica J, Frisvad, Jens C, Meis, Jacques F, Hagen, Ferry, Verweij, Paul E, Hibbs, David E, Lai, Felcia, Groundwater, Paul W, Samson, Robert A, Kidd, Sarah E, Barrs, Vanessa R, Houbraken, Jos

“…The past decade has seen an increase in aspergillosis in humans and animals due to species complex members. Azole resistance is common to these infections,…”
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Understanding Hygroscopicity of Theophylline via a Novel Cocrystal Polymorph: A Charge Density Study by Stanton, Stephen A, Du, Jonathan J, Lai, Felcia, Stanton, Gyte, Hawkins, Bryson A, Ong, Jennifer A, Groundwater, Paul W, Platts, James A, Hibbs, David E

“…The charge density distribution in a novel cocrystal (1) complex of 1,3-dimethylxanthine (theophylline) and propanedioic acid (malonic acid) has been…”
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Tubulin-Binding 3,5-Bis(styryl)pyrazoles as Lead Compounds for the Treatment of Castration-Resistant Prostate Cancer by Liao, Vivian W Y, Kumari, Anuradha, Narlawar, Rajeshwar, Vignarajan, Soma, Hibbs, David E, Panda, Dulal, Groundwater, Paul W

“…The microtubule-binding taxanes, docetaxel and cabazitaxel, are administered intravenously for the treatment of castration-resistant prostate cancer (CRPC) as…”
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New Delhi metallo-β-lactamase-1: structure, inhibitors and detection of producers by Groundwater, Paul W, Xu, Sophia, Lai, Felcia, Váradi, Linda, Tan, Jinlong, Perry, John D, Hibbs, David E

“…Since its discovery in 2008, New Delhi metallo-β-lactamase-1 (NDM-1)-producing Enterobacteriaceae have disseminated globally, facilitated predominantly by gut…”
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Synthesis and evaluation of novel chromogenic peptidase substrates based on 9-(4′-aminophenyl)-10-methylacridinium salts as diagnostic tools in clinical bacteriology by Anderson, Rosaleen J., Groundwater, Paul W., Huang, Yongxue, James, Arthur L., Orenga, Sylvain, Rigby, Annette, Roger-Dalbert, Céline, Perry, John D.

“…The synthesis and evaluation of novel chromogenic peptidase substrates 4a– g with good species specificity are described. The synthesis and initial evaluation…”
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Exploring the Solubility of the Carbamazepine–Saccharin Cocrystal: A Charge Density Study by Du, Jonathan J, Stanton, Stephen A, Fakih, Slaiman, Hawkins, Bryson A, Williams, Peter A, Groundwater, Paul W, Overgaard, Jacob, Platts, James A, Hibbs, David E

“…Carbamazepine (CBZ) is used in the treatment of multiple neurological conditions. Although efficacious, its potential has been limited by its poor solubility,…”
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An experimental and theoretical charge density study of theophylline and malonic acid cocrystallization by Hawkins, Bryson A, Du, Jonathan J, Lai, Felcia, Stanton, Stephen A, Williams, Peter A, Groundwater, Paul W, Platts, James A, Overgaard, Jacob, Hibbs, David E

“…The pharmaceutical agent theophylline (THEO) is primarily used as a bronchodilator and is commercially available in both tablet and liquid dosage forms. THEO…”
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Analyzing Hydration Differences in Cocrystal Polymorphs: High-Resolution X‑ray Investigation of Caffeine–Glutaric Acid Cocrystals by Hawkins, Bryson A, Han, Jaeyeon, Du, Jonathan J, Lai, Felcia, Stanton, Stephen A, Divakarla, Shravan S, Groundwater, Paul W, Platts, James A, Hibbs, David E

“…Two polymorphic forms of caffeine (CAF)–glutaric acid (GLU) cocrystals have been studied via high-resolution X-ray crystallography and Bader’s quantum theory…”
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A latent green fluorescent styrylcoumarin probe for the selective growth and detection of Gram negative bacteria by Váradi, Linda, Wang, Miaoyi, Mamidi, Ramesh R., Luo, Jia Lin, Perry, John D., Hibbs, David E., Groundwater, Paul W.

“…[Display omitted] A novel, green fluorescent β-alanylstyrylcoumarin derivative was synthesized and evaluated for its performance as a fluorogenic enzyme…”
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