Search Results - "Grouix, B"

PBI-4050 reduces liver damage and fibrosis in a high-fat diet mouse model of obesity and metabolic syndrome by Grouix, B, Sarra-Bournet, F, Tremblay, M, Felton, A, Laurin, P, Gagnon, L

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PBI-4050 Decreases Hepatic Stellate Cell Activation and Ameliorates Fibrosis in Carbon Tetrachloride (CCL4)- Induced Hepatic Fibrosis Model by Sarra-Bournet, F, Grouix, B, Hince, K, Felton, A, Tremblay, M, Abbott, S, Duceppe, J.-S, Zacharie, B, Laurin, P, Gagnon, L

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Oral Treatment with PBI-4425 Decreases Fibrosis in Carbon Tetrachloride (CCL4)-Induced Hepatic Fibrosis Model by Grouix, B, Sarra-Bournet, F, Hince, K, Felton, A, Tremblay, M, Abbott, S, Duceppe, J.-S, Zacharie, B, Laurin, P, Gagnon, L

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P72 ORAL TREATMENT WITH PBI-4050, A NOVEL FIRST-IN-CLASS ANTI-FIBROTIC COMPOUND, REDUCES HEPATIC FIBROSIS AND HEPATOCELLULAR CARCINOMA by Gagnon, L, Geerts, L, Doucet, A, Sarra-Bournet, F, Tremblay, M, Hince, K, Abbott, S, Duceppe, J.-S, Zacharie, B, Penney, C, Laurin, P, Grouix, B

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D29 UNRAVELING THE EXTRACELLULAR MATRIX: Pbi-4050 Reduces Expression Of Fibrosis Biomarkers In The Biomap Saemyof Primary Human Small Airway Epithelial Cells And Lung Myofibroblasts System by Leduc, M, Grouix, B, Laurin, P, Gagnon, L

“…Protein biomarker expression levels relative to vehicle control were determined in cells treated with PBI-4050 (63 to 500 ^M), and biomarkers were designated…”
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D109 UNDERSTANDING THE MECHANISMS OF ACUTE LUNG INJURY: Plasminogen Reduces Acute Lung Injury In An Acute Pancreatitis Model by Gagnon, L, Geerts, L, Grouix, B, Tremblay, M, Sarra-Bournet, F, Felton, A, Laurin, P

“…Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in acute pancreatitis still represents a substantial problem, with a…”
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D109 UNDERSTANDING THE MECHANISMS OF ACUTE LUNG INJURY: Oral Treatment With Pbi-4050 Reduces Acute Lung Injury In An Acute Pancreatitis Model by Gagnon, L, Geerts, L, Grouix, B, Tremblay, M, Sarra-Bournet, F, Felton, A, Laurin, P

“…Background: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) in acute pancreatitis still represents a substantial problem, with a…”
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C79 ADVANCING UNDERSTANDING OF OBSTRUCTIVE LUNG DISEASE: MEDICATIONS AND MECHANISMS OF DELIVERY: Pbi-4425, A Novel First-In-Class Anti-Inflammatory/anti-Fibrotic Compound, Reduces Pulmonary Emphysema And Cutaneous Hyperplasia In Tight-Skin (fbn-1) Mouse by Gagnon, L, Geerts, L, Cloutier, M-P, Richard, J, Ouboudinar, J, Laurin, P, Grouix, B

“…Rationale: Tight-skin (TSK) mouse, the experimental model for scleroderma, develops cutaneous hyperplasia, cardiac hypertrophy, pulmonary emphysema and…”
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C75 FIBROSIS: CURRENT AND FUTURE APPROACHES: Pbi-4425, A Novel First-In-Class Anti-Inflammatory/anti-Fibrotic Compound, Inhibits Collagen I And CTgf Production In Human Fibroblasts, And Reduces Lung Fibrosis In The Bleomycin-Induced Lung Fibrosis Model by Leduc, M, Tremblay, M, Grouix, B, Sarra-Bournet, F, Felton, A, Laurin, P, Gagnon, L

“…The aim of this study was to investigate the effect of PBI-4425, a first-in-class anti-fibrotic compound, on collagen I expression in TGF-β1-stimulated human…”
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LBP-006 - PBI-4050, a potential anti-fibrotic drug, improves liver fibrosis in Alström Syndrome, an ultra-rare disease by Baig, S., Geberhiwot, T., Gagnon, L., Grouix, B., Laurin, P., Foulkes, L., Dorion, C., Cesari, F., Vaughan, O., Moran, J.

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PBI-4050, a potential anti-fibrotic drug, improves liver fibrosis in Alström Syndrome, an ultra-rare disease by Baig, S., Geberhiwot, T., Gagnon, L., Grouix, B., Laurin, P., Foulkes, L., Dorion, C., Cesari, F., Vaughan, O., Moran, J.

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THU-376 - PBI-4050 reduces liver damage and fibrosis in a high-fat diet mouse model of obesity and metabolic syndrome by Grouix, B., Sarra-Bournet, F., Tremblay, M., Felton, A., Laurin, P., Gagnon, L.

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In Vitro and in Vivo Properties of Bicyclic Lactam Inhibitors: A Novel Class of Low Molecular Weight Peptidomimetic Thrombin Inhibitors by Leblond, L., Grouix, B., Boudreau, C., Yang, Q., Siddiqui, M.A., Winocour, P.D.

“…We have developed potent and selective thrombin inhibitors with a novel non-peptidic structure. A bicyclic lactam was used as the scaffold on which various P1…”
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FRI-104 - PBI-4547 decreases hepatic stellate cell activation via AMPK signaling pathway, and reduces fibrosis in carbon tetrachloride (CCL4)-induced hepatic fibrosis model by Sarra-Bournet, François, Grouix, B., Hince, K., Felton, A., Tremblay, Mikaël, Abbott, S., Duceppe, J.-S., Zacharie, B., Laurin, P., Gagnon, L.

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PBI-4547 decreases hepatic stellate cell activation via AMPK signaling pathway, and reduces fibrosis in carbon tetrachloride (CCL4)-induced hepatic fibrosis model by Sarra-Bournet, François, Grouix, B., Hince, K., Felton, A., Tremblay, Mikaël, Abbott, S., Duceppe, J.-S., Zacharie, B., Laurin, P., Gagnon, L.

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In Vitro and in Vivo Properties of Bicyclic Lactam Inhibitors by Leblond, L., Grouix, B., Boudreau, C., Yang, Q., Siddiqui, M.A., Winocour, P.D.

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Coordinate expression of group II phospholipase A2 and the acute‐phase proteins haptoglobin (HP) and α1‐anti‐chymotrypsin (ACH) by HepG2 cells by VADAS, P., GROUIX, B., STEFANSKI, E., WLOCH, M., PRUZANSKI, W., SCHROEDER, J., GAULDIE, J.

“…The early response to inflammation is characterized by the synthesis of a variety of proteins under cytokine and glucocorticoid control. During episodes of…”
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Induction of TNF-alpha and proinflammatory secretory phospholipase A2 by intravenous administration of CAMPATH-1H in patients with rheumatoid arthritis by Pruzanski, W, Urowitz, M B, Grouix, B, Vadas, P

“…To test the effect of infusions of CAMPATH-1H on levels of proinflammatory secretory phospholipase A2 (sPLA2) and tumor necrosis factor alpha (TNF-alpha) in…”
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A61 LUNG FIBROSIS: ANIMAL MODELS II: Pbi-4050, A Novel First-In-Class Anti-Fibrotic Compound, Inhibits CTgf And Collagen I Production In Human Alveolar Epithelial Cells And Fibroblasts, And Reduces Lung Fibrosis In The Bleomycin-Induced Lung Fibrosis Model by Leduc, M, Tremblay, M, Grouix, B, Sarra-Bournet, F, Felton, A, Laurin, P, Gagnon, L

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SAT-405 - PBI-4050 Decreases Hepatic Stellate Cell Activation and Ameliorates Fibrosis in Carbon Tetrachloride (CCL4)- Induced Hepatic Fibrosis Model by Sarra-Bournet, F., Grouix, B., Hince, K., Felton, A., Tremblay, M., Abbott, S., Duceppe, J.-S., Zacharie, B., Laurin, P., Gagnon, L.

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