Search Results - "Groudine, M"

Looping versus linking: toward a model for long-distance gene activation by Bulger, M, Groudine, M

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Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation by Clurman, B E, Sheaff, R J, Thress, K, Groudine, M, Roberts, J M

“…Cyclin E is a mammalian G1 cyclin that is both required and rate limiting for entry into S phase. The expression of cyclin E is periodic, peaking at the G1-S…”
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Methylation-Mediated Proviral Silencing Is Associated with MeCP2 Recruitment and Localized Histone H3 Deacetylation by Lorincz, Matthew C., Schübeler, Dirk, Groudine, Mark

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Genomic Targeting of Methylated DNA: Influence of Methylation on Transcription, Replication, Chromatin Structure, and Histone Acetylation by Schübeler, Dirk, Lorincz, Matthew C., Cimbora, Daniel M., Telling, Agnes, Feng, Yong-Quing, Bouhassira, Eric E., Groudine, Mark

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Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation by Krumm, A, Hickey, L B, Groudine, M

“…We have shown previously that the majority of RNA polymerase II complexes initiated at the c-myc gene are paused in the promoter-proximal region, similar to…”
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Enhancers Increase the Probability But not the Level of Gene Expression by Walters, Mark C., Fiering, Steven, Eidemiller, Jeff, Magis, Wendy, Groudine, Mark, David I. K. Martin

“…We have studied enhancer function in transient and stable expression assays in mammalian cells by using systems that distinguish expressing from nonexpressing…”
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The block to transcriptional elongation within the human c-myc gene is determined in the promoter-proximal region by KRUMM, A, MEULIA, T, BRUNVAND, M, GROUDINE, M

“…A conditional block to transcriptional elongation is an important mechanism for regulating c-myc gene expression. This elongation block within the first c-myc…”
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Transcriptional enhancers act in cis to suppress position-effect variegation by Walters, M C, Magis, W, Fiering, S, Eidemiller, J, Scalzo, D, Groudine, M, Martin, D I

“…We have examined the basis of enhancer effects on gene expression by altering the action of enhancers on expression of a stably integrated reporter gene. We…”
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Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3 by Hug, Bruce A., Wesselschmidt, Robin L., Fiering, Steven, Bender, M. A., Epner, Elliot, Groudine, Mark, Ley, Timothy J.

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Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA by Pati, Debananda, Keller, Charles, Groudine, Mark, Plon, Sharon E.

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A deletion of the human β-globin locus activation region causes a major alteration in chromatin structure and replication across the entire β-globin locus by FORRESTER, W. C, EPNER, E, DRISCOLL, M. C, ENVER, T, BRICE, M, PAPAYANNOPOULOU, T, GROUDINE, M

“…Naturally occurring deletions that remove sequences located approximately 60 kb upstream of the human adult beta-globin gene result in the failure to…”
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Inhibition of Tcf3 Binding by I-mfa Domain Proteins by Snider, Lauren, Thirlwell, Hilary, Miller, Jeffrey R., Moon, Randall T., Groudine, Mark, Tapscott, Stephen J.

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Controlling the double helix by Felsenfeld, Gary, Groudine, Mark

“…Chromatin is the complex of DNA and proteins in which the genetic material is packaged inside the cells of organisms with nuclei. Chromatin structure is…”
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Replication Initiation Patterns in the β-Globin Loci of Totipotent and Differentiated Murine Cells: Evidence for Multiple Initiation Regions by Aladjem, Mirit I., Rodewald, Luo Wei, Lin, Chii Mai, Bowman, Sarah, Cimbora, Daniel M., Brody, Linnea L., Epner, Elliot M., Groudine, Mark, Wahl, Geoffrey M.

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Gene Therapy of Rat 9L Gliosarcoma Tumors by Transduction with Selectable Genes Does Not Require Drug Selection by Tapscott, S. J., Miller, A. D., Olson, J. M., Berger, M. S., Groudine, M., Spence, A. M.

“…9L rat glioma cells have been used as a model for brain tumor therapies. It has been reported that in vivo infection of 9L cells with a replication-defective…”
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Cellular Latency in Human Immunodeficiency Virus-Infected Individuals with High CD4 Levels can be Detected by the Presence of Promoter-Proximal Transcripts by Adams, Melanie, Sharmeen, Lamia, Kimpton, Jaculyn, Romeo, Joseph M., Garcia, J. Victor, Peterlin, B. Matija, Groudine, Mark, Emerman, Michael

“…We have investigated the molecular basis of human immunodeficiency virus type 1 (HIV-1) latency in a tissue culture model and in HIV-infected people. We show…”
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Molecular Analysis of the Human β -globin Locus Activation Region by Forrester, William C., Novak, Ulrike, Gelinas, Richard, Groudine, Mark

“…Recently, DNA sequences containing four erythroid-specific DNase I hypersensitive sites within 20 kilobases 5′ of the human ε -globin gene have been identified…”
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Transcriptional regulation of hemoglobin switching in chicken embryos [Gene regulation at both the cellular and molecular levels] by Groudine, M, Peretz, M, Weintraub, H

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Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas by BENTLEY, D. L, GROUDINE, M

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A Developmentally Stable Chromatin Structure in the Human β -globin Gene Cluster by Forrester, William C., Thompson, Craig, Elder, J. T., Groudine, Mark

“…The DNase I-hypersensitive sites in the human embryonic β -globin gene region have been mapped in erythroid-enriched fractions of disaggregated fetal livers,…”
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