Protective effect of Uncaria tomentosa extract against oxidative stress and genotoxicity induced by glyphosate-Roundup® using zebrafish (Danio rerio) as a model

Oxidative stress and DNA damage are involved in the glyphosate-based herbicide toxicity. Uncaria tomentosa (UT; Rubiaceae) is a plant species from South America containing bioactive compounds with known beneficial properties. The objective of this work was to evaluate the antioxidant and antigenotox...

Full description

Saved in:

Bibliographic Details
Published in:	Environmental science and pollution research international Vol. 25; no. 12; pp. 11703 - 11715
Main Authors:	Santo, Glaucia Dal, Grotto, Alan, Boligon, Aline A., Da Costa, Bárbara, Rambo, Cassiano L., Fantini, Emily A., Sauer, Elisa, Lazzarotto, Luan M. V., Bertoncello, Kanandra T., Júnior, Osmar Tomazelli, Garcia, Solange C., Siebel, Anna M., Rosemberg, Denis B., Magro, Jacir Dal, Conterato, Greicy M. M., Zanatta, Leila
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-04-2018 Springer Nature B.V
Subjects:	Animals Antioxidants Antioxidants - pharmacology Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bioactive compounds Biocompatibility Brain damage Cat's Claw - chemistry Danio rerio Deoxyribonucleic acid DNA DNA Damage Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Exposure Female Genotoxicity Glycine - analogs & derivatives Glycine - antagonists & inhibitors Glycine - toxicity Glyphosate Herbicides Herbicides - antagonists & inhibitors Herbicides - toxicity Lipid Peroxidation Liver Liver - drug effects Male Oxidative stress Oxidative Stress - drug effects Peroxidation Phenolic compounds Phenols Plant Extracts - pharmacology Plant species Research Article South America Thiols Toxicity Uncaria tomentosa Waste Water Technology Water Management Water Pollution Control Zebrafish Zebrafish Bioactive compounds Antioxidant activity Pesticides Acute toxicity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Oxidative stress and DNA damage are involved in the glyphosate-based herbicide toxicity. Uncaria tomentosa (UT; Rubiaceae) is a plant species from South America containing bioactive compounds with known beneficial properties. The objective of this work was to evaluate the antioxidant and antigenotoxic potential of UT extract in a model of acute exposure to glyphosate-Roundup® (GR) in zebrafish ( Danio rerio ). We showed that UT (1.0 mg/mL) prevented the decrease of brain total thiols, the increase of lipid peroxidation in both brain and liver, and the decrease of liver GPx activity caused after 96 h of GR (5.0 mg/L) exposure. In addition, UT partially protected against the increase of micronucleus frequency induced by GR exposure in fish brain. Overall, our results indicate that UT protects against damage induced by a glyphosate-based herbicide by providing antioxidant and antigenotoxic effects, which may be related to the phenolic compounds identified in the extract.
ISSN:	0944-1344 1614-7499
DOI:	10.1007/s11356-018-1350-6